CRID3 sodium salt - ≥98%(HPLC), high purity , CAS No.256373-96-3

Item Number

C287926

Grouped product items
SKU	Size	Availability	Price
C287926-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$58.90
C287926-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$93.90
C287926-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$192.90
C287926-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$315.90
C287926-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$494.90

Potent NLRP3 inflammasome inhibitor; inhibits IL-1β production

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Basic Description

Synonyms	KBio1_000672 \| sodium 1,2,3,5,6,7-hexahydro-s-indacen-4-ylcarbamoyl-[[4-(1-hydroxy-1-methyl-ethyl)-2-furyl]sulfonyl]azanide \| MCC950 sodium salt \| AKOS025147369 \| EN300-214108 \| s7809 \| MCC950 (CP-456773) sodium \| ethyl 1,4-dihydro-7-methoxy-4-oxoquinolin
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent NLRP3 inflammasome inhibitor; closes the active conformation of NLRP3 to the inactive state. Directly interacts with the Walker B motif within the NLRP3 NACHT domain. Inhibits IL-1β, IL-18 and IL-1α production (IC50values are 7.2, 10.3 and 12-18 nM
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Product Description	application： CP-456773 sodium salt has been used : In in vivo experiments to study the neuroprotective action of ketogenic diet. To study the effect of inhibition of NLRP3 (nod-like receptor protein 3) inflammasome activity on tumor progression in mouse models. To study the cholesterol crystal-mediated IL-1b (interleukin-1b) response in placental explants.

Names and Identifiers

IUPAC Name	sodium;1,2,3,5,6,7-hexahydro-s-indacen-4-ylcarbamoyl-[4-(2-hydroxypropan-2-yl)furan-2-yl]sulfonylazanide
INCHI	InChI=1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q;+1/p-1
InChi Key	LFQQNXFKPNZRFT-UHFFFAOYSA-M
Canonical SMILES	CC(C)(C1=COC(=C1)S(=O)(=O)[N-]C(=O)NC2=C3CCCC3=CC4=C2CCC4)O.[Na+]
Isomeric SMILES	CC(C)(C1=COC(=C1)S(=O)(=O)[N-]C(=O)NC2=C3CCCC3=CC4=C2CCC4)O.[Na+]
PubChem CID	91826093
Molecular Weight	426.46

Certificates

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5 results found

Lot Number	Certificate Type	Date	Item
C2214011	Certificate of Analysis	Feb 17, 2022	C287926
C2214012	Certificate of Analysis	Feb 17, 2022	C287926
C2214019	Certificate of Analysis	Feb 17, 2022	C287926
C2214020	Certificate of Analysis	Feb 17, 2022	C287926
C2214021	Certificate of Analysis	Feb 17, 2022	C287926

Solubility

Solvent:water, Max Conc. mg/mL: 42.65, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 42.65, Max Conc. mM: 100

Sensitivity

Sensitive to humidity, heat, air

Melt Point(°C)

239 °C

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Basic Description