| Synonyms | N-VINYL-2-PYRROLIDONE|88-12-0|1-vinylpyrrolidin-2-one|N-Vinylpyrrolidone|1-Vinyl-2-pyrrolidone|9003-39-8|1-Vinyl-2-pyrrolidinone|N-Vinyl-2-pyrrolidinone|Povidone|Vinylpyrrolidone|N-Vinylpyrrolidinone|1-ethenylpyrrolidin-2-one|2-Pyrrolidinone, 1-ethenyl-|1 | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Specifications & Purity | Ph.Eur, USP/NF, JP, E 1202 | |||||||||||||||||||||||||
| Storage Temp | Room temperature | |||||||||||||||||||||||||
| Shipped In | Normal | |||||||||||||||||||||||||
| Grade | E 1202, JP, Ph.Eur., USP/NF | |||||||||||||||||||||||||
| Product Description | C494178, Crospovidone, is unsurpassed in its performance and versatility as a superdisintegrant in formulations. It combines different mechanisms to achieve rapid tablet disintegration at low concentrations (1-5%). Due to its viscoelasticity, C494178 is highly compactable, resulting in robust tablets with increased tensile strength and reduced friability. Scanning electron microscope images of C494178 show a granular and porous structure with a large surface area. It enhances the dissolution of poorly soluble drug actives and due to its non-ionic property, it does not bear any risk of interaction with cationic APIs. C494178 is available in two particle sizes to serve different application requirements. Benefits: 1.Rapid disintegration at low concentrations (1-5%) 2.Functions via a combination of disintegration mechanisms (wicking, shape recovery, and swelling), thus imparting its unsurpassed versatility as a 3.superdisintegrant in formulations 4.Suitability for use in direct compression, wet granulation, and dry granulation 5.Increased tablet tensile strength and reduced friability due to high compressibility 6.No gel formation even at higher concentrations (10%) – ideal for ODTs Product specifications and parameters:
|
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| IUPAC Name | 1-ethenylpyrrolidin-2-one |
|---|---|
| INCHI | InChI=1S/C6H9NO/c1-2-7-5-3-4-6(7)8/h2H,1,3-5H2 |
| InChi Key | WHNWPMSKXPGLAX-UHFFFAOYSA-N |
| Canonical SMILES | C=CN1CCCC1=O |
| Isomeric SMILES | C=CN1CCCC1=O |
| WGK Germany | 1 |
| PubChem CID | 6917 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 F2415198 | Certificate of Analysis | May 17, 2024 | C494178 |
| F2415223 | Certificate of Analysis | May 17, 2024 | C494178 |
| F2415254 | Certificate of Analysis | May 17, 2024 | C494178 |
| A2431082 | Certificate of Analysis | Jan 24, 2024 | C494178 |
| A2431083 | Certificate of Analysis | Jan 24, 2024 | C494178 |
| A2431084 | Certificate of Analysis | Jan 24, 2024 | C494178 |
| Sensitivity | Moisture sensitive；Heat sensitive |
|---|---|
| Melt Point(°C) | >300℃ |
| Pictogram(s) | GHS08, GHS05, GHS07 |
|---|---|
| Signal | Danger |
| Hazard Statements | H335:May cause respiratory irritation H351:Suspected of causing cancer H373:Causes damage to organs through prolonged or repeated exposure H302:Harmful if swallowed H318:Causes serious eye damage H312:Harmful in contact with skin H332:Harmful if inhaled |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P319:Get medical help if you feel unwell. |
| WGK Germany | 1 |
Starting at $116.90
Starting at $24.90
Starting at $90.90
Starting at $20.90
Starting at $49.90
Starting at $34.90
Starting at $148.90
Starting at $29.90
Starting at $136.90
Starting at $37.90
Starting at $32.90
Starting at $53.90
Starting at $89.90
Starting at $29.90
