Skip to the beginning of the images gallery

Crotamiton - 97%,predominantly trans, high purity , CAS No.483-63-6, Inhibitor of TRPV4

Moligand™
≥97%(predominantly trans)

CAS#: 483-63-6
Formula: C₁₃H₁₇NO
Molecular Weight: 203.28
EC Number: 207-596-3
MDL number: MFCD00026989
PubChem CID: 688020
PubChem SID: 488191073

Item Number

N102062

Grouped product items
SKU	Size	Availability	Price
N102062-1g	1g	In stock	$15.90
N102062-5g	5g	In stock	$30.90
N102062-25g	25g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$136.90
N102062-100g	100g	In stock	$490.90
N102062-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$2,209.90

Scabicidal and antipruritic agent

View related series

TRPV4 Inhibitor

Basic Description

Synonyms	crotamiton\|483-63-6\|N-Ethyl-o-crotonotoluidide\|trans-Crotamiton\|Crotamitone\|Eurax\|Crotalgin\|124236-29-9\|Veteusan\|Crotamitex\|Eurasil\|Euraxil\|Crotamitonum\|Crotonyl-N-ethyl-o-toluidine\|Crotamiton, (E)-\|2-Butenamide, N-ethyl-N-(2-methylphenyl)-\|(E)-N-ethyl-N-
Specifications & Purity	Moligand™, ≥97%(predominantly trans)
Biochemical and Physiological Mechanisms	Scabicidal and antipruritic agent. Toxic to the scabies mite.
Storage Temp	Argon charged
Shipped In	Normal
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of TRPV4
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Properties

ALogP	2.8

Associated Targets

CTNNBIP1 Tbio Beta-catenin-interacting protein 1 0 Activities

Discover Target: CTNNBIP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Discover Target: CYP1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CNR1 Tclin Cannabinoid receptor 1 0 Activities

Discover Target: CNR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD2 Tclin D(2) dopamine receptor 0 Activities

Discover Target: DRD2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD4 Tchem D(4) dopamine receptor 0 Activities

Discover Target: DRD4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ERBB2 Tclin Receptor tyrosine-protein kinase erbB-2 0 Activities

Discover Target: ERBB2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ELANE Tclin Neutrophil elastase 0 Activities

Discover Target: ELANE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EGFR Tclin Epidermal growth factor receptor 0 Activities

Discover Target: EGFR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AVPR1A Tclin Vasopressin V1a receptor 0 Activities

Discover Target: AVPR1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HMGCR Tclin 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0 Activities

Discover Target: HMGCR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HRH1 Tclin Histamine H1 receptor 0 Activities

Discover Target: HRH1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

Discover Target: SLCO1B3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC6A3 Tclin Sodium-dependent dopamine transporter 0 Activities

Discover Target: SLC6A3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC6A4 Tclin Sodium-dependent serotonin transporter 0 Activities

Discover Target: SLC6A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SIGMAR1 Tclin Sigma non-opioid intracellular receptor 1 0 Activities

Discover Target: SIGMAR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPV4 Tchem Transient receptor potential cation channel subfamily V member 4 0 Activities

Discover Target: TRPV4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities

Discover Target: PTGS1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CA2 Tclin Carbonic anhydrase 2 0 Activities

Discover Target: CA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD3 Tclin D(3) dopamine receptor 0 Activities

Discover Target: DRD3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FLT1 Tclin Vascular endothelial growth factor receptor 1 0 Activities

Discover Target: FLT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM3 Tclin Muscarinic acetylcholine receptor M3 0 Activities

Discover Target: CHRM3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM4 Tclin Muscarinic acetylcholine receptor M4 0 Activities

Discover Target: CHRM4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA2B Tclin Alpha-2B adrenergic receptor 0 Activities

Discover Target: ADRA2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA2C Tclin Alpha-2C adrenergic receptor 0 Activities

Discover Target: ADRA2C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR2A Tclin 5-hydroxytryptamine receptor 2A 0 Activities

Discover Target: HTR2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA2A Tclin Adenosine receptor A2a 0 Activities

Discover Target: ADORA2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACHE Tclin Acetylcholinesterase 0 Activities

Discover Target: ACHE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA1B Tclin Alpha-1B adrenergic receptor 0 Activities

Discover Target: ADRA1B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

Discover Target: ADRA2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA1A Tclin Alpha-1A adrenergic receptor 0 Activities

Discover Target: ADRA1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AR Tclin Androgen receptor 0 Activities

Discover Target: AR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAOA Tclin Amine oxidase [flavin-containing] A 0 Activities

Discover Target: MAOA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKR1B1 Tclin Aldose reductase 0 Activities

Discover Target: AKR1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA1 Tclin Adenosine receptor A1 0 Activities

Discover Target: ADORA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR1A Tclin 5-hydroxytryptamine receptor 1A 0 Activities

Discover Target: HTR1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA3 Tchem Adenosine receptor A3 0 Activities

Discover Target: ADORA3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR6 Tchem 5-hydroxytryptamine receptor 6 0 Activities

Discover Target: HTR6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR2B Tclin 5-hydroxytryptamine receptor 2B 0 Activities

Discover Target: HTR2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EDNRA Tclin Endothelin-1 receptor 0 Activities

Discover Target: EDNRA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRD1 Tclin Delta-type opioid receptor 0 Activities

Discover Target: OPRD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRK1 Tclin Kappa-type opioid receptor 0 Activities

Discover Target: OPRK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRM1 Tclin Mu-type opioid receptor 0 Activities

Discover Target: OPRM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NOS2 Tchem Nitric oxide synthase, inducible 0 Activities

Discover Target: NOS2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TACR1 Tclin Substance-P receptor 0 Activities

Discover Target: TACR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NOS1 Tchem Nitric oxide synthase, brain 0 Activities

Discover Target: NOS1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488191073
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488191073
IUPAC Name	(E)-N-ethyl-N-(2-methylphenyl)but-2-enamide
INCHI	InChI=1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3/b8-4+
InChi Key	DNTGGZPQPQTDQF-XBXARRHUSA-N
Canonical SMILES	CCN(C1=CC=CC=C1C)C(=O)C=CC
Isomeric SMILES	CCN(C1=CC=CC=C1C)C(=O)/C=C/C
WGK Germany	3
RTECS	GQ7000000
PubChem CID	688020
Molecular Weight	203.28

Database links

PubChem CID	688020
CAS Registry No.	483-63-6
PubChem SID	488191073

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

13 results found

Lot Number	Certificate Type	Date	Item
K1920201	Certificate of Analysis	Sep 07, 2023	N102062
J1922163	Certificate of Analysis	Aug 01, 2023	N102062
J1922165	Certificate of Analysis	Aug 01, 2023	N102062
H2308917	Certificate of Analysis	May 20, 2023	N102062
H2308922	Certificate of Analysis	May 20, 2023	N102062
H2308923	Certificate of Analysis	May 20, 2023	N102062
H2308930	Certificate of Analysis	May 20, 2023	N102062
H2308936	Certificate of Analysis	May 20, 2023	N102062
H2308939	Certificate of Analysis	May 20, 2023	N102062
C2208423	Certificate of Analysis	Jan 24, 2022	N102062
C2208430	Certificate of Analysis	Jan 24, 2022	N102062
C2208448	Certificate of Analysis	Jan 24, 2022	N102062
C2209067	Certificate of Analysis	Jan 24, 2022	N102062

Chemical and Physical Properties

Sensitivity	air sensitive
Refractive Index	1.54
Flash Point(°F)	235.4 °F
Flash Point(°C)	113 °C
Boil Point(°C)	153-155°C/13mmHg

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H302:Harmful if swallowed H317:May cause an allergic skin reaction
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help.
WGK Germany	3
RTECS	GQ7000000

References

1. Kittaka H, Yamanoi Y, Tominaga M. (2017) Transient receptor potential vanilloid 4 (TRPV4) channel as a target of crotamiton and its bimodal effects.. Pflugers Arch, 469 (10): (1313-1323). [PMID:28612138]
2. F Forton,B Seys,J L Marchal,A M Song. (1998-05-15) Demodex folliculorum and topical treatment: acaricidal action evaluated by standardized skin surface biopsy.. The British journal of dermatology, 138 ((3)): (461-466). [PMID:9580800]
3. S M Hwang,M S Yoo,S K Ahn,E H Choi. (1998-09-10) Demodecidosis manifested on the external genitalia.. International journal of dermatology, 37 ((8)): (634-636). [PMID:9732019]
4. P D Morgan-Glenn. (2001-09-05) Scabies.. Pediatrics in review, 22 ((9)): (322-323). [PMID:11533383]
5. S A Holme,C M Mills. (2001-10-13) Crotamiton and narrow-band UVB phototherapy: novel approaches to alleviate pruritus of breast carcinoma skin infiltration.. Journal of pain and symptom management, 22 ((4)): (803-805). [PMID:11596612]
6. M Bigby. (2002-07-10) A systematic review of the treatment of scabies.. Archives of dermatology, 136 ((3)): (387-389). [PMID:12102094]
7. Godfrey Walker,Paul Johnstone. (2002-09-17) Scabies.. Clinical evidence, ((7)(7)): (1543-1548). [PMID:12230770]
8. Noriko Ohtaki,Hiroko Taniguchi,Hiroshi Ohtomo. (2003-05-30) Oral ivermectin treatment in two cases of scabies: effective in crusted scabies induced by corticosteroid but ineffective in nail scabies.. The Journal of dermatology, 30 ((5)): (411-416). [PMID:12773808]
9. Naoki Oiso,Kazuyoshi Fukai,Masamitsu Ishii. (2004-03-05) Triple allergic contact sensitivities due to ferbinac, crotamiton and diisopropanolamine.. Contact dermatitis, 49 ((5)): (261-263). [PMID:14996052]
10. H Hara,T Masuda,A Yokoyama,H Asaki,T Okada,H Suzuki. (2004-03-05) Allergic contact dermatitis due to crotamiton.. Contact dermatitis, 49 ((4)): (219-219). [PMID:14996078]
11. Habib Ansarin,Mir Hadi Aziz Jalali,Shadi Mazloomi,Razieh Soltani-Arabshahi,Roya Setarehshenas. (2006-04-28) Scabies presenting with bullous pemphigoid-like lesions.. Dermatology online journal, 12 ((1)): (19-19). [PMID:16638387]
12. M COUPERUS. (1949-07-01) The use of N-ethyl-o-crotonotoluidide in the treatment of scabies and various pruritic dermatoses.. The Journal of investigative dermatology, 13 ((1)): (35-42). [PMID:18133471]
13. N Nakada,M Yasojima,Y Okayasu,K Komori,Y Suzuki. (2010-04-08) Mass balance analysis of triclosan, diethyltoluamide, crotamiton and carbamazepine in sewage treatment plants.. Water science and technology : a journal of the International Association on Water Pollution Research, 61 ((7)): (1739-1747). [PMID:20371932]
14. A Parodi,F Drago,S Paolino,E Cozzani,R Gallo. (2011-09-13) [Treatment of rosacea].. Annales de dermatologie et de venereologie, 138 Suppl 2 (S158-S162). [PMID:21907876]
15. Rika Sekine,Takahiro Satoh,Ayumi Takaoka,Kazumi Saeki,Hiroo Yokozeki. (2012-03-03) Anti pruritic effects of topical crotamiton, capsaicin, and a corticosteroid on pruritogen-induced scratching behavior.. Experimental dermatology, 21 ((3)): (201-204). [PMID:22379965]
16. Shuji Fukahori,Taku Fujiwara,Ryusei Ito,Naoyuki Funamizu. (2012-05-15) Photocatalytic decomposition of crotamiton over aqueous TiO(2) suspensions: determination of intermediates and the reaction pathway.. Chemosphere, 89 ((3)): (213-220). [PMID:22578794]
17. G J Walker,P W Johnstone. (2000-05-05) Interventions for treating scabies.. The Cochrane database of systematic reviews, (2) ((2)): (CD000320-CD000320). [PMID:10796527]
18. Kyoung-Jin Kim,Kyung-Hyun Roh,Jee-Ho Choi,Kyung-Jeh Sung,Kee-Chan Moon,Jai-Kyoung Koh. (2002-10-18) Scabies incognito presenting as urticaria pigmentosa in an infant.. Pediatric dermatology, 19 ((5)): (409-411). [PMID:12383096]
19. Maria Wesołowska,Wojciech Baran,Jacek Szepietowski,Larysa Hirschberg,Stanisław Jankowski. (2006-08-18) [Demodicidosis in humans as a current problem in dermatology].. Wiadomosci parazytologiczne, 51 ((3)): (253-256). [PMID:16913532]
20. E Dika,A Tosti,M Goldovsky,R Wester,H I Maibach. (2006-09-19) Percutaneous absorption of crotamiton in man following single and multiple dosing.. Cutaneous and ocular toxicology, 25 ((3)): (211-216). [PMID:16980246]
21. Ulrich R Hengge,Bart J Currie,Gerold Jäger,Omar Lupi,Robert A Schwartz. (2006-11-25) Scabies: a ubiquitous neglected skin disease.. The Lancet. Infectious diseases, 6 ((12)): (769-779). [PMID:17123897]
22. Yuji Higaki. (2007-03-08) [Treatment for scabies].. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 44 ((1)): (126-126). [PMID:17342823]
23. Ahmed M Al-Arfaj,Gary R Mullen,Rafiaa Rashad,Ahmed Abdel-Hameed,Barry M OConnor,Ibrahim S Alkhalife,Roland R Dute. (2007-05-10) A human case of otoacariasis involving a histiostomatid mite (Acari: Histiostomatidae).. The American journal of tropical medicine and hygiene, 76 ((5)): (967-971). [PMID:17488924]
24. M Royer,C-M Latre,C Paul,J Mazereeuw-Hautier. (2008-12-17) [Infantile scabies].. Annales de dermatologie et de venereologie, 135 ((12)): (876-881). [PMID:19084706]
25. Maren Kahle,Ignaz J Buerge,Markus D Müller,Thomas Poiger. (2009-08-18) Hydrophilic anthropogenic markers for quantification of wastewater contamination in ground- and surface waters.. Environmental toxicology and chemistry, 28 ((12)): (2528-2536). [PMID:19681643]
26. Keisuke Kuroda,Michio Murakami,Kumiko Oguma,Yuki Muramatsu,Hideshige Takada,Satoshi Takizawa. (2011-12-24) Assessment of groundwater pollution in Tokyo using PPCPs as sewage markers.. Environmental science & technology, 46 ((3)): (1455-1464). [PMID:22191375]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.