Crotonoyl coenzyme A trilithium salt - ~90% (HPLC), high purity

  • ≥90%(HPLC)
Item Number
C485916
Grouped product items
SKUSizeAvailabilityPrice Qty
C485916-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$947.90
C485916-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$4,395.90

Basic Description

Specifications & Purity≥90%(HPLC)
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

Description

Crotonoyl coenzyme A (Crotonoyl -CoA) may be used in anti-tubercular and anti-malarial drug research as a substrate to help identify and characterized enzymes such as Plasmodium falciparum enoyl-ACP reductase (PfENR) and other enoyl-CoA reductases that may be effective drug targets. Crotonoyl -CoA may be used as a substrate analogue for kinetic studies on ß-hydroxyacyl-acyl carrier protein (ACP) dehydratase (FabZ).

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility H2O: 50mg/mL, clear, colorless

Related Documents

References

1. Mili Kapoor,P L Swarna Mukhi,Namita Surolia,K Suguna,Avadhesha Surolia.  (2004-05-06)  Kinetic and structural analysis of the increased affinity of enoyl-ACP (acyl-carrier protein) reductase for triclosan in the presence of NAD+..  The Biochemical journal,  381  ((Pt 3)): (725-733).  [PMID:15125687]
2. Sara Tucci,William Martin.  (2007-03-27)  A novel prokaryotic trans-2-enoyl-CoA reductase from the spirochete Treponema denticola..  FEBS letters,  581  ((8)): (1561-1566).  [PMID:17382934]
3. Weixuan Yu,Carla Neckles,Andrew Chang,Gopal Reddy Bommineni,Lauren Spagnuolo,Zhuo Zhang,Nina Liu,Christina Lai,James Truglio,Peter J Tonge.  (2015-02-17)  A [(32)P]NAD(+)-based method to identify and quantitate long residence time enoyl-acyl carrier protein reductase inhibitors..  Analytical biochemistry,  474  (40-49).  [PMID:25684450]
4. Erica N Parker,Bryon S Drown,Emily J Geddes,Hyang Yeon Lee,Nahed Ismail,Gee W Lau,Paul J Hergenrother.  (2019-11-20)  Implementation of permeation rules leads to a FabI inhibitor with activity against Gram-negative pathogens..  Nature microbiology,  ((1)): (67-75).  [PMID:31740764]
5. Michaella J Levy,David C Montgomery,Mihaela E Sardiu,Jose L Montano,Sarah E Bergholtz,Kellie D Nance,Abigail L Thorpe,Stephen D Fox,Qishan Lin,Thorkell Andresson,Laurence Florens,Michael P Washburn,Jordan L Meier.  (2019-12-15)  A Systems Chemoproteomic Analysis of Acyl-CoA/Protein Interaction Networks..  Cell chemical biology,  27  ((3)): (322-333).  [PMID:31836350]
6. Kezhi Yan,Justine Rousseau,Keren Machol,Laura A Cross,Katherine E Agre,Cynthia Forster Gibson,Anne Goverde,Kendra L Engleman,Hannah Verdin,Elfride De Baere,Lorraine Potocki,Dihong Zhou,Maxime Cadieux-Dion,Gary A Bellus,Monisa D Wagner,Rebecca J Hale,Natacha Esber,Alan F Riley,Benjamin D Solomon,Megan T Cho,Kirsty McWalter,Roy Eyal,Meagan K Hainlen,Bryce A Mendelsohn,Hillary M Porter,Brendan C Lanpher,Andrea M Lewis,Juliann Savatt,Isabelle Thiffault,Bert Callewaert,Philippe M Campeau,Xiang-Jiao Yang.  (2020-02-06)  Deficient histone H3 propionylation by BRPF1-KAT6 complexes in neurodevelopmental disorders and cancer..  Science advances,  ((4)): (eaax0021-eaax0021).  [PMID:32010779]
7. L M Schopfer,V Massey,S Ghisla,C Thorpe.  (1988-08-23)  Oxidation-reduction of general acyl-CoA dehydrogenase by the butyryl-CoA/crotonyl-CoA couple. A new investigation of the rapid reaction kinetics..  Biochemistry,  27  ((17)): (6599-6611).  [PMID:3219356]
8. C F Chiang.  (1987-01-01)  Purification of rat liver microsomal trans-2-enoyl-CoA reductase..  Preparative biochemistry,  17  ((4)): (315-325).  [PMID:3438247]
9. Peng Liao,Nimisha Bhattarai,Bo Cao,Xiang Zhou,Ji Hoon Jung,Krishna Damera,Taylor T Fuselier,Suresh Thareja,William C Wimley,Binghe Wang,Shelya X Zeng,Hua Lu.  (2020-02-10)  Crotonylation at serine 46 impairs p53 activity..  Biochemical and biophysical research communications,  524  ((3)): (730-735).  [PMID:32035620]

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