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CTOP TFA - ≥95%, high purity , CAS No.103429-31-8, Antagonist of μ receptor

  • Moligand™
  • ≥95%
Item Number
C275118
Grouped product items
SKUSizeAvailabilityPrice Qty
C275118-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$83.90
C275118-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$249.90
C275118-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$399.90
C275118-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$799.90
C275118-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,266.90
C275118-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,999.90
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Potent, selective μ opioid receptor antagonist

View related series
μ receptor Antagonist

Basic Description

SynonymsCTOP|CTOPA|103429-31-8|Ctop-NH2|Phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide|N-(1-amino-3-hydroxy-1-oxobutan-2-yl)-19-[(2-amino-3-phenylpropanoyl)amino]-10-(3-aminopropyl)-7-(1-hydroxyethyl)-16-[(4-hydroxyph
Specifications & Purity≥95%
Storage TempStore at -20°C,Desiccated
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of μ receptor
Product Description

CTOP TFA is a potent and highly selective μ-opioid receptor antagonist. CTOP TFA antagonizes the acute analgesic effect and hypermotility. CTOP TFA enhances extracellular dopamine levels in the nucleus accumbens. CTOP TFA dose-dependently enhances locomotor activity

Associated Targets

OPRM1 Tclin Mu-type opioid receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name N-(1-amino-3-hydroxy-1-oxobutan-2-yl)-19-[(2-amino-3-phenylpropanoyl)amino]-10-(3-aminopropyl)-7-(1-hydroxyethyl)-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-3,3-dimethyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
INCHI InChI=1S/C50H67N11O11S2/c1-26(62)39(42(53)65)59-49(72)41-50(3,4)74-73-25-38(58-43(66)33(52)21-28-11-6-5-7-12-28)47(70)56-36(22-29-16-18-31(64)19-17-29)45(68)57-37(23-30-24-54-34-14-9-8-13-32(30)34)46(69)55-35(15-10-20-51)44(67)60-40(27(2)63)48(71)61-41/h5-9,11-14,16-19,24,26-27,33,35-41,54,62-64H,10,15,20-23,25,51-52H2,1-4H3,(H2,53,65)(H,55,69)(H,56,70)(H,57,68)(H,58,66)(H,59,72)(H,60,67)(H,61,71)
InChi Key PZWWYAHWHHNCHO-UHFFFAOYSA-N
Canonical SMILES CC(C1C(=O)NC(C(SSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN)CC2=CNC3=CC=CC=C32)CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=CC=C5)N)(C)C)C(=O)NC(C(C)O)C(=O)N)O
Isomeric SMILES CC(C1C(=O)NC(C(SSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN)CC2=CNC3=CC=CC=C32)CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=CC=C5)N)(C)C)C(=O)NC(C(C)O)C(=O)N)O
PubChem CID 2884
Molecular Weight 1062.28（free base）

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12 results found

Lot NumberCertificate TypeDateItem
C2404378Certificate of AnalysisFeb 01, 2024 C275118
C2414348Certificate of AnalysisFeb 01, 2024 C275118
C2414349Certificate of AnalysisFeb 01, 2024 C275118
C2414350Certificate of AnalysisFeb 01, 2024 C275118
C2414351Certificate of AnalysisFeb 01, 2024 C275118
C2414352Certificate of AnalysisFeb 01, 2024 C275118
C2414353Certificate of AnalysisFeb 01, 2024 C275118
C2414359Certificate of AnalysisFeb 01, 2024 C275118
C2414360Certificate of AnalysisFeb 01, 2024 C275118
C2414377Certificate of AnalysisFeb 01, 2024 C275118
C2414379Certificate of AnalysisFeb 01, 2024 C275118
C2414380Certificate of AnalysisFeb 01, 2024 C275118

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Chemical and Physical Properties

SolubilitySoluble in water

Related Documents

 SDS

 Specification Sheet

References

1. Wang Z et al..  (2021)  Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition..  Brain,  144  (2): (665-681).  [PMID:33367648]

Solution Calculators

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