Cucurbitacin B - 98%, high purity , CAS No.6199-67-3, Agonist of TAS2R10

Item Number

C348066

Grouped product items
SKU	Size	Availability	Price
C348066-5mg	5mg	In stock	$117.90
C348066-25mg	25mg	In stock	$402.90
C348066-100mg	100mg	In stock	$1,450.90

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Basic Description

Synonyms	Cucurbitacin B\|6199-67-3\|Amarine\|Datisca principle B\|DATISCACIN\|Datiscn Principle B\|(+)-Cucurbitacin B\|1,2-Dihydro-alpha-elaterin\|0115W5MABF\|CHEBI:3941\|CUCURBITACIN R - DATISCA PRINCIPLE B\|NSC49451\|NSC-49451\|NSC-144154\|Cucurbitacin B hydrate\|(R,E)-6-((2S,
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Cucurbitacin B also exhibits anti-cancer activity by inhibiting telomerase and c-Myc in breast cancer. It also exhibits anti- artherosclerotic activity. Cucurbitacin B also possesses anti-inflammatory and anti-microbial activity. Cucurbitacin B is a trite
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of TAS2R10
Product Description	Application： Cucurbitacin B hydrate has been used: as a signal transducer and activator of transcription 3 (stat3) inhibitor to determine its effect on the expression of human lysosomal acid lipase (hLAL) in myeloid-derived suppressor cells (MDSCs). as an ecdysone receptor (EcR) antagonist injection to lower the levels of 20-hydoxyecdysone (20E) signaling in butterflies. to determine its effect on the cell viability of pancreatic cancer cell lines.

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	[(E,6R)-6-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate
INCHI	InChI=1S/C32H46O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-13,19-22,25,34-35,39H,11,14-16H2,1-9H3/b13-12+/t19-,20+,21-,22+,25+,29+,30-,31+,32+/m1/s1
InChi Key	IXQKXEUSCPEQRD-DKRGWESNSA-N
Canonical SMILES	CC(=O)OC(C)(C)C=CC(=O)C(C)(C1C(CC2(C1(CC(=O)C3(C2CC=C4C3CC(C(=O)C4(C)C)O)C)C)C)O)O
Isomeric SMILES	CC(=O)OC(C)(C)/C=C/C(=O)[C@@](C)([C@H]1[C@@H](C[C@@]2([C@@]1(CC(=O)[C@@]3([C@H]2CC=C4[C@H]3C[C@@H](C(=O)C4(C)C)O)C)C)C)O)O
Alternate CAS	6199-67-3
PubChem CID	5281316
NSC Number	49451
MeSH Entry Terms	cucurbitacin B;cucurbitacin B 2-sulfate
Molecular Weight	558.7

Certificates

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3 results found

Lot Number	Certificate Type	Date	Item
C2310017	Certificate of Analysis	Dec 19, 2022	C348066
C2310217	Certificate of Analysis	Dec 19, 2022	C348066
C2310218	Certificate of Analysis	Dec 19, 2022	C348066

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H300:Fatal if swallowed
Precautionary Statements	P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately.

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Basic Description