Cusatuzumab (anti-CD70) - Primary antibody, specific to CD70, >95%, high purity, Human IgG1, INHIBITOR of CD70 antigen inhibitor

Features and benefits

Short Overview:
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
Species reactivity(Reacts with): Cynomolgus monkey,Human,Mouse,Rhesus monkey
Isotype: Human IgG1

Application:

Item Number

Ab170844

Grouped product items
SKU	Size	Availability	Price
Ab170844-100μg	100μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$69.90
Ab170844-1mg	1mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$327.90
Ab170844-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$687.90
Ab170844-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,107.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

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Basic Description

Product Name	Cusatuzumab (anti-CD70) - Primary antibody, specific to CD70, >95%, high purity, Human IgG1
Synonyms	CD 27L antibody; CD 70 antibody; CD27 L antibody; CD27 LG antibody; CD27 ligand antibody; CD27-L antibody; CD27L antibody; CD27LG antibody; CD70 antibody; CD70 antigen antibody; CD70 molecule antibody; CD70_HUMAN antibody; Ki 24 antigen antibody; Ki24 ant
Specifications & Purity	ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot
Specificity	CD70
Conjugation	Unconjugated
Grade	Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type	INHIBITOR
Mechanism of action	INHIBITOR of CD70 antigen inhibitor
Product Description	Cusatuzumab (anti-CD70) is a human αCD70 monoclonal antibody. Cusatuzumab (anti-CD70) shows cytotoxicity activity with enhanced antibody-dependent cellular. Cusatuzumab (anti-CD70) reduces leukemia stem cells (LSCs) and triggers gene signatures related to myeloid differentiation and apoptosis. Cusatuzumab (anti-CD70) has the potential for the research of Acute myeloid leukemia (AML). Purity >95% (SDS-PAGE&SEC) Endotoxin Level < 1.0EU/mg

Product Properties

Isotype	Human IgG1
Light Chain Type	lambda C2
SDS-PAGE	27.5 kDa (Light Chain) & 51.0 kDa (Heavy Chain), under reducing conditions; 170.7 kDa, under non-reducing conditions.
Purification Method	Protein A purified
Purity	>95%
Form	Liquid
Concentration	Lot by Lot
Storage Temp	Store at -80°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS	1864871-20-4

Certificates

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3 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0607381	Certificate of Analysis	Jun 26, 2024	Ab170844
ZJ23F1001417	Certificate of Analysis	Oct 26, 2023	Ab170844
ZJ23F1001418	Certificate of Analysis	Oct 26, 2023	Ab170844

References

1. Bowman, M R MR and 5 more authors.. (1994) The cloning of CD70 and its identification as the ligand for CD27.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:8120384]
2. Goodwin, R G RG and 9 more authors.. (1993) Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor.. Cell, (7): [PMID:8387892]
3. Izawa, Kazushi K and 15 more authors.. (2017) Inherited CD70 deficiency in humans reveals a critical role for the CD70-CD27 pathway in immunity to Epstein-Barr virus infection.. The Journal of experimental medicine, [PMID:28011863]
4. Abolhassani, Hassan H and 32 more authors.. (2017) Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency.. The Journal of experimental medicine, [PMID:28011864]

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Basic Description