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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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C650488-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $160.90 | |
C650488-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $690.90 | |
C650488-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,100.90 |
Synonyms | CV-6209|100488-87-7|CV 6209|117064-08-1|2-(N-Acetyl-N-(2-methoxy-3-octadecylcarbamoyloxypropoxycarbonyl)aminomethyl)-1-ethylpyridinium|[2-methoxy-3-(octadecylcarbamoyloxy)propyl] N-acetyl-N-[(1-ethylpyridin-1-ium-2-yl)methyl]carbamate;chloride|CV 6209 Chl |
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Specifications & Purity | ≥95% |
Biochemical and Physiological Mechanisms | CV-6209 is a potent antagonist of platelet activating factor (PAF) . CV-6209 inhibits the PAF-induced aggregation of rabbit and human platelets, with IC 50 s of 75 nM and 170 nM, respectively. CV-6209 can inhibit PAF-induced hypotension in rats. |
Storage Temp | Store at 2-8°C,Desiccated |
Shipped In | Wet ice |
Product Description | CV-6209 is a potent antagonist of platelet activating factor (PAF) . CV-6209 inhibits the PAF-induced aggregation of rabbit and human platelets, with IC 50 s of 75 nM and 170 nM, respectively. CV-6209 can inhibit PAF-induced hypotension in rats In Vitro CV-6209 inhibits [ 3 H]serotonin release from rabbit platelets stimulated with PAF (30 nM). CV-6209 has little action on platelet aggregation induced by arachidonic acid, ADP, or collagen. CV-6209 (0.2-2 μM; pretreated for 30 min) inhibits PAF-induced MC degranulation in both LAD2 and hLMCs. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo CV-6209 (i.v.) inhibits PAF (0.3 μg/kg; i.v.)-induced hypotension in rats (ED 50 =0.009 mg/kg) with no effect on the hypotension induced by arachidonic acid, histamine, bradykinin and isoproterenol . CV-6209 (66 μg; i.v.) reduces asparaginase-induced hypersensitivity compared with nonpretreated, sensitized mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Oil IC50& Target:platelet activating factor (PAF) |
Ki Data | PAF-R: Ki= 0.32 nM (human); PAF-R: Ki= 7.2 nM (guinea pig) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | [2-methoxy-3-(octadecylcarbamoyloxy)propyl] N-acetyl-N-[(1-ethylpyridin-1-ium-2-yl)methyl]carbamate;chloride |
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INCHI | InChI=1S/C34H59N3O6.ClH/c1-5-7-8-9-10-11-12-13-14-15-16-17-18-19-20-22-25-35-33(39)42-28-32(41-4)29-43-34(40)37(30(3)38)27-31-24-21-23-26-36(31)6-2;/h21,23-24,26,32H,5-20,22,25,27-29H2,1-4H3;1H |
InChi Key | APUCCVGQZPNXIO-UHFFFAOYSA-N |
Canonical SMILES | CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC1=CC=CC=[N+]1CC)C(=O)C)OC.[Cl-] |
Isomeric SMILES | CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC1=CC=CC=[N+]1CC)C(=O)C)OC.[Cl-] |
PubChem CID | 107756 |
Molecular Weight | 642.31 |
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