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CAMK:Calcium/calmodulin-dependent protein kinases
CX-5279 , CAS No.C609627, Inhibitor of Pim-1 proto-oncogene; serine/threonine kinase

CX-5279 , CAS No.C609627, Inhibitor of Pim-1 proto-oncogene; serine/threonine kinase

Item Number

C609627

Grouped product items
SKU	Size	Availability	Price	Qty
C609627-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$600.90
C609627-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of Pim-1 proto-oncogene; serine/threonine kinase

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	3-(cyclopropylamino)-5-[3-(trifluoromethyl)anilino]pyrimido[4,5-c]quinoline-8-carboxylate
INCHI	InChI=1S/C22H16F3N5O2/c23-22(24,25)12-2-1-3-14(9-12)27-19-18-16(10-26-21(30-18)28-13-5-6-13)15-7-4-11(20(31)32)8-17(15)29-19/h1-4,7-10,13H,5-6H2,(H,27,29)(H,31,32)(H,26,28,30)/p-1
InChi Key	UXZATHOFDZQOMY-UHFFFAOYSA-M
Canonical SMILES	[O-]C(=O)c1ccc2c(c1)nc(c1c2cnc(n1)NC1CC1)Nc1cccc(c1)C(F)(F)F
Isomeric SMILES	C1CC1NC2=NC=C3C4=C(C=C(C=C4)C(=O)[O-])N=C(C3=N2)NC5=CC=CC(=C5)C(F)(F)F
PubChem CID	72200387

PubChem CID	72200387
BindingDB Ligand	92757

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1. Battistutta R, Cozza G, Pierre F, Papinutto E, Lolli G, Sarno S, O'Brien SE, Siddiqui-Jain A, Haddach M, Anderes K et al.. (2011) Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer.. Biochemistry, 50 (39): (8478-88). [PMID:21870818]

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