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Cyclo(-His-Pro) - 98%, high purity , CAS No.53109-32-3

  • ≥98%
Item Number
C339850
Grouped product items
SKUSizeAvailabilityPrice Qty
C339850-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$68.90
C339850-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$89.90
C339850-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$159.90
C339850-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$288.90
C339850-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$519.90

a cyclic dipeptide containing histidine and proline

Basic Description

SynonymsCyclo(his-pro)|Cyclo(-His-Pro)|53109-32-3|Cyclo(L-His-L-Pro)|MLS000028694|Q10817UXVT|CYCLO-(L-HISTIDINE-L-PROLINE) INHIBITOR|SMR000058881|UNII-Q10817UXVT|L-His-L-Pro-DKP|1w1t|Opera_ID_1205|L,L-cyclo(histidylprolyl)|Cyclo(histidyl-proline);Histidylproline
Specifications & Purity≥98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

Cyclo(his-pro) (Cyclo(histidyl-proline)) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone. Cyclo(his-pro) could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) can cross the brain-blood-barrier and affect diverse inflammatory and stress responses. 

Application:

Cyclo(L-His-L-Pro) is a versatile molecule and it finds application in biochemical and metabolomics research.

Associated Targets

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SMN1 Tchem Survival motor neuron protein 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (3S,8aS)-3-(1H-imidazol-5-ylmethyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
INCHI InChI=1S/C11H14N4O2/c16-10-9-2-1-3-15(9)11(17)8(14-10)4-7-5-12-6-13-7/h5-6,8-9H,1-4H2,(H,12,13)(H,14,16)/t8-,9-/m0/s1
InChi Key NAKUGCPAQTUSBE-IUCAKERBSA-N
Canonical SMILES C1CC2C(=O)NC(C(=O)N2C1)CC3=CN=CN3
Isomeric SMILES C1C[C@H]2C(=O)N[C@H](C(=O)N2C1)CC3=CN=CN3
WGK Germany 3
PubChem CID 449094
Molecular Weight 234.26

Certificates

Certificate of Analysis(COA)

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10 results found

Lot NumberCertificate TypeDateItem
E2430172Certificate of AnalysisApr 22, 2024 C339850
E2430173Certificate of AnalysisApr 22, 2024 C339850
E2430174Certificate of AnalysisApr 22, 2024 C339850
E2430180Certificate of AnalysisApr 22, 2024 C339850
E2430184Certificate of AnalysisApr 22, 2024 C339850
E2430188Certificate of AnalysisApr 22, 2024 C339850
E2430189Certificate of AnalysisApr 22, 2024 C339850
E2430190Certificate of AnalysisApr 22, 2024 C339850
E2430195Certificate of AnalysisApr 22, 2024 C339850
E2430196Certificate of AnalysisApr 22, 2024 C339850

Chemical and Physical Properties

SolubilitySoluble in water (Miscible).
Refractive Indexn20D~1.63 (Predicted)
Specific Rotation[α]+54.8° to +55.5°(c=10 in 0.2 ml 6N NH4OH/100 ml H2O)
Boil Point(°C)744.8° C at 760 mmHg
Melt Point(°C)165-170° C

Safety and Hazards(GHS)

WGK Germany 3

Related Documents

Solution Calculators