| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| C275170-1mg | 1mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,030.90 |
Cell-permeable Smo/Hh/GLI1 signaling inhibitor
| Synonyms | KAAD-Cyclopamine|Cyclopamine-KAAD|306387-90-6|N-[2-[(3'R,7'aR)-3',6',10,11b-tetramethyl-3-oxospiro[1,2,4,6,6a,6b,7,8,11,11a-decahydrobenzo[a]fluorene-9,2'-3,3a,5,6,7,7a-hexahydrofuro[3,2-b]pyridine]-4'-yl]ethyl]-6-(3-phenylpropanoylamino)hexanamide|DTXSID |
|---|---|
| Specifications & Purity | 96% |
| Storage Temp | Store at -20°C,Argon charged,Desiccated |
| Shipped In | Dry ice |
| Product Description | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
| IUPAC Name | N-[2-[(3'R,7'aR)-3',6',10,11b-tetramethyl-3-oxospiro[1,2,4,6,6a,6b,7,8,11,11a-decahydrobenzo[a]fluorene-9,2'-3,3a,5,6,7,7a-hexahydrofuro[3,2-b]pyridine]-4'-yl]ethyl]-6-(3-phenylpropanoylamino)hexanamide |
|---|---|
| INCHI | InChI=1S/C44H63N3O4/c1-29-25-39-42(47(28-29)24-23-46-40(49)13-9-6-10-22-45-41(50)17-14-32-11-7-5-8-12-32)31(3)44(51-39)21-19-35-36-16-15-33-26-34(48)18-20-43(33,4)38(36)27-37(35)30(44)2/h5,7-8,11-12,15,29,31,35-36,38-39,42H,6,9-10,13-14,16-28H2,1-4H3,(H,45,50)(H,46,49)/t29?,31-,35?,36?,38?,39-,42?,43?,44?/m1/s1 |
| InChi Key | WDHRPWOAMDJICD-BWBMXWGBSA-N |
| Canonical SMILES | CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(=O)CCC6(C5CC4=C3C)C)C)N(C1)CCNC(=O)CCCCCNC(=O)CCC7=CC=CC=C7 |
| Isomeric SMILES | C[C@@H]1C2[C@@H](CC(CN2CCNC(=O)CCCCCNC(=O)CCC3=CC=CC=C3)C)OC14CCC5C6CC=C7CC(=O)CCC7(C6CC5=C4C)C |
| PubChem CID | 16760383 |
| Molecular Weight | 697.99 |
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| Solubility | Soluble in DMSO and in ethanol |
|---|---|
| Sensitivity | Hygroscopic |
| 1. Lau ST et al.. (2019) Activation of Hedgehog Signaling Promotes Development of Mouse and Human Enteric Neural Crest Cells, Based on Single-Cell Transcriptome Analyses.. Gastroenterology, 157 (6): (1556-1571.e5). [PMID:31442438] |
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