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Cyclophosphamide monohydrate - 97%, high purity , DNA inhibitor, CAS No.6055-19-2, DNA inhibitor

≥97%

CAS#: 6055-19-2
Formula: C₇H₁₅Cl₂N₂O₂P·H₂O
Molecular Weight: 279.1
Beilstein Registry Number: 4678992
EC Number: 629-456-4,640-398-9
MDL number: MFCD00149395
PubChem CID: 22420

Item Number

C106991

Grouped product items
SKU	Size	Availability	Price
C106991-1g	1g	In stock	$22.90
C106991-5g	5g	In stock	$87.90
C106991-25g	25g	In stock	$294.90
C106991-100g	100g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,060.90
C106991-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$4,770.90

View related series

Alkylating antitumor agents Pharmaceutical ingredients

Basic Description

Synonyms	Cyclophosphamide monohydrate\|6055-19-2\|Cyclophosphamide hydrate\|Neosar\|Endoxan monohydrate\|Revimmune\|2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide hydrate\|Cyclophosphamide (hydrate)\|Ciclophosphamide hydrat\|Ciclofosfamide\|Cycloblastin\|6055-19-
Specifications & Purity	≥97%
Storage Temp	Store at 2-8°C,Argon charged
Shipped In	Wet ice
Action Type	INHIBITOR
Mechanism of action	DNA inhibitor
Product Description	Cyclophosphamide monohydrate is an alkylating, cytotoxic agent experimentally shown to crosslink DNA, causing strand breakage and inducing mutations. It is also believed to possess immunosuppressive properties. Cyclophosphamide Monohydrate inhibits ALDH1 (aldehyde dehydrogenase 1) through its degradation product acrolein, as well as induces apoptosis in the rat thymus via the Fas/Fas ligand pathway. An immunosuppressive, cytotoxic apoptosis inducer.

Associated Targets

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GMNN Tbio Geminin 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RUNX1 Tbio Runt-related transcription factor 1 0 Activities

Discover Target: RUNX1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SMAD3 Tchem Mothers against decapentaplegic homolog 3 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALOX15 Tchem Arachidonate 15-lipoxygenase 0 Activities

Discover Target: ALOX15

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

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TARDBP Tchem TAR DNA-binding protein 43 0 Activities

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NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 0 Activities

Discover Target: NFE2L2

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KDM4E Tchem Lysine-specific demethylase 4E 0 Activities

Discover Target: KDM4E

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MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Discover Target: MAPK1

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Names and Identifiers

IUPAC Name	N,N-bis(2-chloroethyl)-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine;hydrate
INCHI	InChI=1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2
InChi Key	PWOQRKCAHTVFLB-UHFFFAOYSA-N
Canonical SMILES	C1CNP(=O)(OC1)N(CCCl)CCCl.O
Isomeric SMILES	C1CNP(=O)(OC1)N(CCCl)CCCl.O
WGK Germany	3
RTECS	RP6157750
Alternate CAS	6055-19-2,50-18-0 (Parent)
PubChem CID	22420
UN Number	2811
Packing Group	I
MeSH Entry Terms	(+,-)-2-(bis(2-Chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-Oxide Monohydrate;B 518;B-518;B518;Cyclophosphamide;Cyclophosphamide Anhydrous;Cyclophosphamide Monohydrate;Cyclophosphamide, (R)-Isomer;Cyclophosphamide, (S)-Isomer;Cyclophosphane;Cy
Molecular Weight	279.1
Beilstein	4678992
Reaxy-Rn	8167897

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
K2217398	Certificate of Analysis	Nov 03, 2022	C106991
K2217399	Certificate of Analysis	Nov 03, 2022	C106991
K2217400	Certificate of Analysis	Nov 03, 2022	C106991
K2217404	Certificate of Analysis	Nov 03, 2022	C106991
K2217473	Certificate of Analysis	Nov 03, 2022	C106991

Chemical and Physical Properties

Solubility	Soluble in water (30 mg/ml), ethanol (slightly soluble), benzene (slightly soluble), ethylene glycol (slightly soluble), carbon tetrachloride (slightly soluble), dioxane (slightly soluble), ether (sparingly soluble), acetone (sparingly soluble), alcohol,
Sensitivity	Heat, Light, Air sensitive.
Flash Point(°F)	235.4 °F
Flash Point(°C)	113 °C
Boil Point(°C)	110°C
Melt Point(°C)	49-53°C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H350:May cause cancer
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice.
WGK Germany	3
RTECS	RP6157750
Reaxy-Rn	8167897
Class	6.1
Merck Index	2747

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