Cyclopiazonic acid from Penicillium grisefulvum - 98%, high purity , CAS No.18172-33-3

  • ≥98%
Item Number
C276576
Grouped product items
SKUSizeAvailabilityPrice Qty
C276576-5mg
5mg
In stock
$246.90
C276576-10mg
10mg
In stock
$424.90
C276576-25mg
25mg
In stock
$956.90
C276576-50mg
50mg
In stock
$1,721.90

Discover Cyclopiazonic acid from Penicillium grisefulvum by Aladdin Scientific in 98% for only $246.90. Available - in Ligands at Aladdin Scientific. Ca 2+ -ATPase inhibitor Tags: .

Basic Description

SynonymsNSC 117181,(6aS,11aR,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-6a,7,11a,11b-tetrahydro-2H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9(6H)-one,
Specifications & Purity98%
Storage TempStore at -20°C,Argon charged,Desiccated
Shipped InIce chest + Ice pads
Product Description

Cyclopiazonic acid (CPA), a tetramic acid is synthesized by various Aspergillus and Penicillium species.


Product Application

Cyclopiazonic acid from Penicillium cyclopium has been used:
as a standard in aflatoxin detection and quantification by thin layer chromatography (TLC)
as a component in Ca2+-free DMEM/10% fetal bovine serum (FBS)
as a reversible inhibitor of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) to examine the role of luminal calcium in endoplasmic recticulum (ER)-to-Golgi trafficking
as an endoplasmic reticulum Ca2+-ATPase blocker, to treat neurons and also to study the role of the endoplasmic reticulum (ER) in releasing and sustaining Ca2+ during Ca2+-induced Ca2+ release (CICR) to inhibit SERCA


Names and Identifiers

WGK Germany 3
RTECS UY8587000
Molecular Weight 336.38

Certificates

Certificate of Analysis(COA)

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8 results found

Lot NumberCertificate TypeDateItem
F2316218Certificate of AnalysisMay 09, 2024 C276576
F2316227Certificate of AnalysisApr 11, 2024 C276576
F2315749Certificate of AnalysisApr 11, 2024 C276576
F2315713Certificate of AnalysisApr 11, 2024 C276576
F2315712Certificate of AnalysisMar 20, 2024 C276576
F2315714Certificate of AnalysisMar 20, 2024 C276576
F2315721Certificate of AnalysisMar 20, 2024 C276576
F2316221Certificate of AnalysisMar 20, 2024 C276576

Chemical and Physical Properties

SolubilityDMSO: soluble;chloroform: soluble

Safety and Hazards(GHS)

Pictogram(s) GHS06
Signal Danger
Hazard Statements

H300:Fatal if swallowed

Precautionary Statements

P301+P310:IF SWALLOWED: Immediately call a POISON CENTER/doctor/...

P264:Wash hands [and …] thoroughly after handling.

WGK Germany 3
RTECS UY8587000

Related Documents

References

1. Rossi A et al..  (2021)  Calcium Signaling and Mitochondrial Function in Presenilin 2 Knock-Out Mice: Looking for Any Loss-of-Function Phenotype Related to Alzheimer's Disease..  Cells,  10  (2):   [PMID:33494218]
2. Rossi A et al..  (2020)  Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer's Disease-Related Models..  Cell Rep,  30  (7): (2332-2348.e10).  [PMID:32075767]
3. Clemens AM & Johnston D.  (2014)  Age- and location-dependent differences in store depletion-induced h-channel plasticity in hippocampal pyramidal neurons..  J Neurophysiol,  111  (6): (1369-82).  [PMID:24381027]
4. Gupta K et al..  (2020)  Bile canaliculi contract autonomously by releasing calcium into hepatocytes via mechanosensitive calcium channel..  Biomaterials,  259  (120283).  [PMID:32827796]
5. Engbers JD et al..  (2012)  Intermediate conductance calcium-activated potassium channels modulate summation of parallel fiber input in cerebellar Purkinje cells..  Proc Natl Acad Sci U S A,  109  (7): (2601-6).  [PMID:22308379]
6. Qu L et al..  (2011)  Neuronal Fc-gamma receptor I mediated excitatory effects of IgG immune complex on rat dorsal root ganglion neurons..  Brain Behav Immun,  25  (7): (1399-407).  [PMID:21521651]
7. Fedeli C et al..  (2019)  PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis..  Autophagy,  15  (12): (2044-2062).  [PMID:30892128]

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