Grouped product items

SKU

Size

Availability

Price

Qty

C286653-5mg

5mg

In stock

$77.90

C286653-10mg

10mg

In stock

$116.90

C286653-50mg

50mg

Available within 4-8 weeks(?)

$430.90

C286653-100mg

100mg

In stock

$757.90

Basic Description

Synonyms	945128-26-7\|CYM 5541\|CYM-5541\|CYM5541\|ML249\|N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide\|N,N-dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide\|CHEMBL1970071\|N,N-Dicyclohexyl-5-cyclopropylisoxazole-3-carboxamide\|MLS003675929\|GTPL9494\|VMB12826\|B
Specifications & Purity	Moligand™, ≥97%(HPLC)
Biochemical and Physiological Mechanisms	Selective sphingosine-1-phosphate receptor 3 (S1P3) allosteric agonist (EC50= 72-132 nM). Occupies a different space within the ligand binding pocket of S1P3than S1P. Displays no activity at S1P1, S1P2, S1P4and S1P5receptors at concentrations up to 10μM.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST, ALLOSTERIC MODULATOR
Mechanism of action	Agonist of S1P 3 receptor;Allosteric modulator of S1P 3 receptor

Associated Targets

CNR1 Tclin Cannabinoid receptor 1 0 Activities

Discover Target: CNR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CX3CR1 Tchem CX3C chemokine receptor 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

Discover Target: CYP2C19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GPR35 Tchem G-protein coupled receptor 35 0 Activities

Discover Target: GPR35

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRD4 Tchem Bromodomain-containing protein 4 0 Activities

Discover Target: BRD4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

Discover Target: CDK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

S1PR5 Tclin Sphingosine 1-phosphate receptor 5 0 Activities

Discover Target: S1PR5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

S1PR2 Tchem Sphingosine 1-phosphate receptor 2 0 Activities

Discover Target: S1PR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

S1PR4 Tclin Sphingosine 1-phosphate receptor 4 0 Activities

Discover Target: S1PR4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FFAR4 Tchem Free fatty acid receptor 4 0 Activities

Discover Target: FFAR4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FPR2 Tchem N-formyl peptide receptor 2 0 Activities

Discover Target: FPR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

Discover Target: FGFR3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HRH1 Tclin Histamine H1 receptor 0 Activities

Discover Target: HRH1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CSNK1D Tchem Casein kinase I isoform delta 0 Activities

Discover Target: CSNK1D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

S1PR1 Tclin Sphingosine 1-phosphate receptor 1 0 Activities

Discover Target: S1PR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

S1PR3 Tclin Sphingosine 1-phosphate receptor 3 1 Activities

Discover Target: S1PR3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC6A2 Tclin Sodium-dependent noradrenaline transporter 0 Activities

Discover Target: SLC6A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

Discover Target: TRIM24

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

C5AR1 Tclin C5a anaphylatoxin chemotactic receptor 1 0 Activities

Discover Target: C5AR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRPF1 Tchem Peregrin 0 Activities

Discover Target: BRPF1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKA Tchem Aurora kinase A 0 Activities

Discover Target: AURKA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRB2 Tclin Beta-2 adrenergic receptor 0 Activities

Discover Target: ADRB2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

APLNR Tchem Apelin receptor 0 Activities

Discover Target: APLNR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

Discover Target: ABL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

Discover Target: ADRA2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADGRF1 Tbio Adhesion G-protein coupled receptor F1 0 Activities

Discover Target: ADGRF1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AGTR1 Tclin Type-1 angiotensin II receptor 0 Activities

Discover Target: AGTR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

Discover Target: GSK3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GPR119 Tclin Glucose-dependent insulinotropic receptor 0 Activities

Discover Target: GPR119

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GLP1R Tclin Glucagon-like peptide 1 receptor 0 Activities

Discover Target: GLP1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Discover Target: MAPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N,N-dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide
INCHI	InChI=1S/C19H28N2O2/c22-19(17-13-18(23-20-17)14-11-12-14)21(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h13-16H,1-12H2
InChi Key	NDKGACIWVAOUQH-UHFFFAOYSA-N
Canonical SMILES	C1CCC(CC1)N(C2CCCCC2)C(=O)C3=NOC(=C3)C4CC4
Isomeric SMILES	C1CCC(CC1)N(C2CCCCC2)C(=O)C3=NOC(=C3)C4CC4
WGK Germany	3
PubChem CID	17253208
Molecular Weight	316.44

Database links

PubChem CID	17253208
ChEMBL Ligand	CHEMBL1970071
CAS Registry No.	945128-26-7
RCSB PDB Ligand	JF9
GPCRdb Ligand	CYM-5541

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

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4 results found

Lot Number	Certificate Type	Date	Item
J2119273	Certificate of Analysis	Aug 09, 2024	C286653
J2119282	Certificate of Analysis	Aug 09, 2024	C286653
J2119286	Certificate of Analysis	Aug 09, 2024	C286653
J2119298	Certificate of Analysis	Aug 09, 2024	C286653

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 31.64, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 15.82, Max Conc. mM: 50

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
WGK Germany	3
RIDADR	NONHforallmodesoftransport

References

1. Jo E, Bhhatarai B, Repetto E, Guerrero M, Riley S, Brown SJ, Kohno Y, Roberts E, Schürer SC, Rosen H. (2012) Novel selective allosteric and bitopic ligands for the S1P(3) receptor.. ACS Chem Biol, 7 (12): (1975-83). [PMID:22971058]

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CYM 5541 - ≥97%(HPLC), high purity , CAS No.945128-26-7, Agonist of S1P 3 receptor;Allosteric modulator of S1P 3 receptor

Basic Description

Associated Targets

CNR1 Tclin Cannabinoid receptor 1 0 Activities

CX3CR1 Tchem CX3C chemokine receptor 1 0 Activities

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

GPR35 Tchem G-protein coupled receptor 35 0 Activities

BRD4 Tchem Bromodomain-containing protein 4 0 Activities

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

S1PR5 Tclin Sphingosine 1-phosphate receptor 5 0 Activities

S1PR2 Tchem Sphingosine 1-phosphate receptor 2 0 Activities

S1PR4 Tclin Sphingosine 1-phosphate receptor 4 0 Activities

FFAR4 Tchem Free fatty acid receptor 4 0 Activities

HDAC6 Tclin Histone deacetylase 6 0 Activities

FPR2 Tchem N-formyl peptide receptor 2 0 Activities

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

HRH1 Tclin Histamine H1 receptor 0 Activities

CSNK1D Tchem Casein kinase I isoform delta 0 Activities

S1PR1 Tclin Sphingosine 1-phosphate receptor 1 0 Activities

S1PR3 Tclin Sphingosine 1-phosphate receptor 3 1 Activities

SLC6A2 Tclin Sodium-dependent noradrenaline transporter 0 Activities

TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

C5AR1 Tclin C5a anaphylatoxin chemotactic receptor 1 0 Activities

BRPF1 Tchem Peregrin 0 Activities

AURKA Tchem Aurora kinase A 0 Activities

ADRB2 Tclin Beta-2 adrenergic receptor 0 Activities

APLNR Tchem Apelin receptor 0 Activities

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

ADGRF1 Tbio Adhesion G-protein coupled receptor F1 0 Activities

AGTR1 Tclin Type-1 angiotensin II receptor 0 Activities

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

GPR119 Tclin Glucose-dependent insulinotropic receptor 0 Activities

GLP1R Tclin Glucagon-like peptide 1 receptor 0 Activities

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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