CYM50358 is a potent and selective S1PR4 antagonist, with an IC 50 of 25 nM. CYM50358 can be used for the research of influenza infection
In Vitro
CYM50358 shows less potent inhibition of S1PR1 (IC 50 =6.4 μM). CYM50358 (10 μM) has no effect on the collagen-induced HSP27 phosphorylation, markedly reverses the suppressive effect of S1P on the collagen-induced phosphorylation of HSP27. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
