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CZS-241 , CAS No.C609709, Inhibitor of neurotrophic receptor tyrosine kinase 1;Inhibitor of polo like kinase 4

CZS-241 , CAS No.C609709, Inhibitor of neurotrophic receptor tyrosine kinase 1;Inhibitor of polo like kinase 4

Item Number

C609709

Grouped product items
SKU	Size	Availability	Price	Qty
C609709-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$600.90
C609709-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Synonyms	compound B43;CZS241
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of neurotrophic receptor tyrosine kinase 1;Inhibitor of polo like kinase 4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	2-Chloro-N-(2,5-difluorophenyl)-5-(((1-isopropyl-4-((5-methyl-1H-pyrazol-3-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)methyl)benzamide
INCHI	InChI=1S/C26H24ClF2N9O/c1-13(2)38-24-18(12-31-38)23(33-22-8-14(3)36-37-22)34-26(35-24)30-11-15-4-6-19(27)17(9-15)25(39)32-21-10-16(28)5-7-20(21)29/h4-10,12-13H,11H2,1-3H3,(H,32,39)(H3,30,33,34,35,36,37)
InChi Key	WIOVOFCYNTYNJH-UHFFFAOYSA-N
Canonical SMILES	Cc1cc(Nc2c3c(n(C(C)C)nc3)nc(NCc3cc(C(=O)Nc4cc(F)ccc4F)c(Cl)cc3)n2)n[nH]1

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1. Sun Y, Xue Y, Liu H, Mu S, Sun P, Sun Y, Wang L, Wang H, Wang J, Wu T et al.. (2023) Discovery of CZS-241: A Potent, Selective, and Orally Available Polo-Like Kinase 4 Inhibitor for the Treatment of Chronic Myeloid Leukemia.. J Med Chem, 66 (4): (2396-2421). [PMID:36734825]

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