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D-α-Hydroxyglutaric acid disodium salt - ≥95%, high purity , CAS No.103404-90-6
KDM4A inhibitor; also NF-κB activator
Basic Description Specifications & Purity ≥95% Biochemical and Physiological Mechanisms Oncometabolite produced by mutant isocitrate dehydrogenase 1 (IDH1) and IDH2. Inhibits KDM4A in murine embryonic fibroblasts resulting in activation of mTOR. Also activates NF-κB in bone marrow stromal cells and inhibits FTO (mRNA N6-methyladenine demethy Storage Temp Store at -20°C,Argon charged Shipped In Ice chest + Ice pads Product Description An α hydroxy acid
Names and Identifiers IUPAC Name disodium;(2R)-2-hydroxypentanedioate INCHI InChI=1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m1../s1 InChi Key DZHFTEDSQFPDPP-HWYNEVGZSA-L Canonical SMILES C(CC(=O)[O-])C(C(=O)[O-])O.[Na+].[Na+] Isomeric SMILES C(CC(=O)[O-])[C@H](C(=O)[O-])O.[Na+].[Na+] WGK Germany 3 PubChem CID 51051608 Molecular Weight 192.08 Beilstein 5318040
Chemical and Physical Properties Solubility Solvent:water, Max Conc. mg/mL: 19.21, Max Conc. mM: 100 Specific Rotation[α] +8.0°～ +9.0°(C = 1, H2O)(anhydrous)
Safety and Hazards(GHS) Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H302: Harmful if swallowed
H332: Harmful if inhaled
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
WGK Germany 3
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K2223478