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Applications
Targets
G protein-coupled receptors (GPCRs)
Lysophospholipid (S1P) receptors
D-erythro-sphingosine-1-phosphate (C20 base) - >99%, high purity , CAS No.799812-75-2, Agonist of S1P 2 receptor

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D-erythro-sphingosine-1-phosphate (C20 base) - >99%, high purity , CAS No.799812-75-2, Agonist of S1P 2 receptor

Moligand™
≥99%

CAS#: 799812-75-2
Formula: C₂₀H₄₂NO₅P
Molecular Weight: 407.52
PubChem CID: 46891771

Item Number

D130702

Grouped product items
SKU	Size	Availability	Price	Qty
D130702-1mg	1mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,374.90

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S1P2 receptor Agonist

Basic Description

Synonyms	799812-75-2\|[(E,2S,3R)-2-azaniumyl-3-hydroxyicos-4-enyl] hydrogen phosphate\|S1P d20:1\|(2S,3R,4E)-2-Azaniumyl-3-hydroxyicos-4-en-1-yl hydrogen phosphate\|D-erythro-Sphingosine-C20-1-phosphate\|Sphingosine-1-Phosphate (d20:1)\|GTPL11496\|DTXSID50677069\|S1P (d20
Specifications & Purity	>99%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of S1P 2 receptor
Product Description	product description： Sphingosine-1-phosphate (S1P) is a zwitterionic sphingolipid. It is found in insects, yeasts and plants. Sphingosine-1-Phosphate (d20:1) is a phosphorylated derivative of long chain base C20 sphingosine. application： Sphingosine-1-phosphate (S1P)-d7 has been used as a reference standard in liquid chromatography/tandem mass spectrometry analysis for quantitative analyses of S1P d20:1 in central nervous system of healthy mice and in human glioblastoma tissue. Biochemical mechanism: Sphingosine-1-phosphate (S1P) is an important cellular metabolite and signaling lipid in animal cells. It aids in various physiological and cellular processes such as atherosclerosis, inflammation, immunity, tumorigenesis, and cell proliferation. S1P plays a vital role in mammalian brain and cardiac development. S1P d20:1 serves as a partial agonist at the S1P receptor 2 (S1P2). It has an ability to inhibit S1P d18:1‐mediated cyclooxygenase 2(COX2) induction.

Associated Targets

S1PR2 Tchem Sphingosine 1-phosphate receptor 2 0 Activities

Discover Target: S1PR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	[(E,2S,3R)-2-azaniumyl-3-hydroxyicos-4-enyl] hydrogen phosphate
INCHI	InChI=1S/C20H42NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(22)19(21)18-26-27(23,24)25/h16-17,19-20,22H,2-15,18,21H2,1H3,(H2,23,24,25)/b17-16+/t19-,20+/m0/s1
InChi Key	YUUWWSOTAGQJFW-YIVRLKKSSA-N
Canonical SMILES	CCCCCCCCCCCCCCCC=CC(C(COP(=O)(O)[O-])[NH3+])O
Isomeric SMILES	CCCCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)[O-])[NH3+])O
PubChem CID	46891771
Molecular Weight	407.52

Database links

PubChem CID	46891771
CAS Registry No.	799812-75-2
GPCRdb Ligand	S1P d20:1

Certificates

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2 results found

Lot Number	Certificate Type	Date	Item
H2229286	Certificate of Analysis	Jun 15, 2024	D130702
I2107421	Certificate of Analysis	Jun 15, 2023	D130702

References

1. Vutukuri R, Koch A, Trautmann S, Schreiber Y, Thomas D, Mayser F, Meyer Zu Heringdorf D, Pfeilschifter J, Pfeilschifter W, Brunkhorst R. (2020) S1P d20:1, an endogenous modulator of S1P d18:1/S1P₂ -dependent signaling.. FASEB J, 34 (3): (3932-3942). [PMID:31944406]

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