Discover D-myo-Inositol-1,3,4-triphosphate sodium salt by Aladdin Scientific in ＞98% for only $83.90. Available - in Ligands at Aladdin Scientific. an inhibitor of Ins(3,4,5,6)-P4 kinase activity Tags: .
D-myo-Inositol-1,3,4-triphosphate sodium salt is one of many inositol oligophosphate isomers implicated in signal transduction. Ins(1,3,4)-P3 acts through the inhibition of Ins(3,4,5,6)-P4 kinase activity to increase the cellular level of Ins(3,4,5,6)-P4 and thus inhibit calcium-activated chloride channels. The levels of Ins(1,3,4)-P3 are regulated by the levels of cytosolic free calcium. The receptor-mediated activation of phospholipase C (PLC) can be seen as the initiating event in this cascade, since PLC generates Ins(1,4,5)-P3 which releases calcium from intracellular storage reservoirs. This leads to increase in the cytosolic concentration of free calcium. D-myo-Inositol-1,3,4-triphosphate sodium saltis an inhibitor of Ins(3,4,5,6)-P4 kinase activity
