| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| D423225-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $69.90 |
Endogenous NMDA receptor co-agonist
| Synonyms | D-serine|312-84-5|H-D-Ser-OH|(R)-2-amino-3-hydroxypropanoic acid|(R)-Serine|Serine D-form|(2R)-2-amino-3-hydroxypropanoic acid|Serine, D-|D-Serin|MFCD00004269|C3H7NO3|(2R)-2-amino-3-hydroxy-propanoic acid|CHEMBL285123|DTXSID9041021|CHEBI:16523|1K77H2Z9B1| |
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| Specifications & Purity | Moligand™, 10mM in Water |
| Biochemical and Physiological Mechanisms | Agonist at the NMDA glycine binding site and the inhibitory post-synaptic glycine receptor. |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Grade | Moligand™ |
| Product Description | D-serine has been used as a substrate in D-amino acid oxidase (DAO) activity in human 1321N1 astrocytoma cells. It has also been used in intracerebroventricular administration in rat for the induction of antinociceptive effect. D-serine has been used to prevent glycine-dependent desensitization of N-methyl D-aspartate receptor (NMDAR) and to study its effects on NMDARs to correct behavioral abnormalities in rats after partial sciatic nerve ligation (PSNL) product description： D-serine is an unusual amino acid expressed in the mammalian brain.D-serine is a dextro amino acid present in neurons, astrocytes, and microglia. It is synthesized from L-serine by the enzyme serine racemase. Racemase also catalyzes the breakdown of D-serine into ammonia and pyruvate. It is oxidized to hydroxypyruvate by D-amino acid oxidase. application： D-Serine is involved in the biosynthesis of purines, pyrimidines, and other amino acids. D-Serine also is an agonist of glycine site of the NMDA-type glutamate receptor. It also acts as Lacosamide intermediate. |
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| IUPAC Name | (2R)-2-amino-3-hydroxypropanoic acid |
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| INCHI | InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1 |
| InChi Key | MTCFGRXMJLQNBG-UWTATZPHSA-N |
| Canonical SMILES | C(C(C(=O)O)N)O |
| Isomeric SMILES | C([C@H](C(=O)O)N)O |
| WGK Germany | 3 |
| PubChem CID | 71077 |
| Molecular Weight | 105.09 |
| Beilstein | 1721403 |
| Reaxy-Rn | 1721403 |
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| Specific Rotation[α] | -15 ° (C=10, HCl(1+5)) |
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| Melt Point(°C) | 220°C |
| Pictogram(s) | GHS07 |
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| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
| WGK Germany | 3 |
| Reaxy-Rn | 1721403 |
