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D-Serine - >98.5%, high purity , CAS No.312-84-5, Agonist of GluN1;Agonist of GluN2A;Agonist of GluN2B;Agonist of GluN2C;Agonist of GluN2D

  • Moligand™
  • ≥98.5%
Item Number
S105977
Grouped product items
SKUSizeAvailabilityPrice Qty
S105977-5g
5g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$18.90
S105977-25g
25g
In stock
$72.90
S105977-100g
100g
In stock
$259.90
S105977-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,169.90
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Endogenous NMDA receptor co-agonist

View related series
GluN1 Agonist GluN2A Agonist GluN2B Agonist GluN2C Agonist GluN2D Agonist

Basic Description

SynonymsD-serine|312-84-5|H-D-Ser-OH|(R)-2-amino-3-hydroxypropanoic acid|(R)-Serine|Serine D-form|(2R)-2-amino-3-hydroxypropanoic acid|Serine, D-|D-Serin|MFCD00004269|C3H7NO3|(2R)-2-amino-3-hydroxy-propanoic acid|CHEMBL285123|DTXSID9041021|CHEBI:16523|1K77H2Z9B1|
Specifications & PurityMoligand™, ≥98.5%
Biochemical and Physiological MechanismsAgonist at the NMDA glycine binding site and the inhibitory post-synaptic glycine receptor.
Shipped InNormal
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of GluN1;Agonist of GluN2A;Agonist of GluN2B;Agonist of GluN2C;Agonist of GluN2D
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

D-serine has been used as a substrate in D-amino acid oxidase (DAO) activity in human 1321N1 astrocytoma cells. It has also been used in intracerebroventricular administration in rat for the induction of antinociceptive effect.

D-serine has been used to prevent glycine-dependent desensitization of N-methyl D-aspartate receptor (NMDAR) and to study its effects on NMDARs to correct behavioral abnormalities in rats after partial sciatic nerve ligation (PSNL)


product description：

D-serine is an unusual amino acid expressed in the mammalian brain.D-serine is a dextro amino acid present in neurons, astrocytes, and microglia. It is synthesized from L-serine by the enzyme serine racemase. Racemase also catalyzes the breakdown of D-serine into ammonia and pyruvate. It is oxidized to hydroxypyruvate by D-amino acid oxidase.


application：

D-Serine is involved in the biosynthesis of purines, pyrimidines, and other amino acids. D-Serine also is an agonist of glycine site of the NMDA-type glutamate receptor. It also acts as Lacosamide intermediate.

Associated Targets

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC36A1 Tchem Proton-coupled amino acid transporter 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TXNRD1 Tclin Thioredoxin reductase 1, cytoplasmic 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC1A4 Tbio Neutral amino acid transporter A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RGS4 Tchem Regulator of G-protein signaling 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC16A10 Tbio Monocarboxylate transporter 10 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

LMNA Tbio Prelamin-A/C 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BLM Tchem Bloom syndrome protein 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC1A5 Tchem Neutral amino acid transporter B(0) 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC7A10 Tbio Asc-type amino acid transporter 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIN3A Tclin Glutamate receptor ionotropic, NMDA 3A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIN1 Tclin Glutamate receptor ionotropic, NMDA 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIN2A Tclin Glutamate receptor ionotropic, NMDA 2A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIN2B Tclin Glutamate receptor ionotropic, NMDA 2B 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIN2C Tclin Glutamate receptor ionotropic, NMDA 2C 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIN2D Tclin Glutamate receptor ionotropic, NMDA 2D 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488184641
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488184641
IUPAC Name (2R)-2-amino-3-hydroxypropanoic acid
INCHI InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
InChi Key MTCFGRXMJLQNBG-UWTATZPHSA-N
Canonical SMILES C(C(C(=O)O)N)O
Isomeric SMILES C([C@H](C(=O)O)N)O
WGK Germany 3
PubChem CID 71077
Molecular Weight 105.09
Beilstein 1721403
Reaxy-Rn 1721403

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

14 results found

Lot NumberCertificate TypeDateItem
D2425380Certificate of AnalysisMar 25, 2024 S105977
D2425495Certificate of AnalysisMar 25, 2024 S105977
D2425496Certificate of AnalysisMar 25, 2024 S105977
D2425497Certificate of AnalysisMar 25, 2024 S105977
D2425498Certificate of AnalysisMar 25, 2024 S105977
D2417035Certificate of AnalysisJul 22, 2023 S105977
H2309868Certificate of AnalysisJul 22, 2023 S105977
H2309869Certificate of AnalysisJul 22, 2023 S105977
H2309872Certificate of AnalysisJul 22, 2023 S105977
H2309880Certificate of AnalysisJul 22, 2023 S105977
H2309888Certificate of AnalysisJul 22, 2023 S105977
C2224379Certificate of AnalysisMar 03, 2022 S105977
C2224405Certificate of AnalysisMar 03, 2022 S105977
C2224406Certificate of AnalysisMar 03, 2022 S105977

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Chemical and Physical Properties

SolubilitySoluble in water (346 mg/ml at 20°C), and mineral acids. Insoluble in alcohol, ether, and benzene.
Specific Rotation[α]-15 ° (C=10, HCl(1+5))
Melt Point(°C)220°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
Reaxy-Rn 1721403

Related Documents

 SDS

 Specification Sheet

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  10. N-Z-D-serine methyl ester
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  11. Boc-D-Ser-OH - 98%, used for , CAS No. 6368-20-3, by Aladdin Scientific
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  12. D-Serine ethyl ester hydrochloride
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  16. D-Serine methyl ester hydrochloride
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  17. Fmoc-D-Ser(tBu)-OH
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  18. N-CBZ-D-Serine benzyl ester - , used for , CAS No. 53933-06-5, by Aladdin Scientific
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  19. O-Benzyl-N-(tert-butoxycarbonyl)-D-serine
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  20. N-Fmoc-O-benzyl-D-serine - 97%, used for , CAS No. 122889-11-6, by Aladdin Scientific
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