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Δ12-PGJ2 (Δ12-Prostaglandin J2) - A solution in methyl acetate,98%, high purity , CAS No.87893-54-7, Agonist of DP 1 receptor;Agonist of DP 2 receptor
a decomposition product of PGD2 showing potent antiviral and anti-proliferative activity
Basic Description Synonyms delta-12-Prostaglandin J2|Dddd-PGD2|87893-54-7|Delta12-PGJ2|delta(12)-PGJ2|delta-12-PGJ2|9-Deoxy-delta(9,12)-13,14-dihydro PGD2|9-Deoxy-delta-9,12-prostaglandin D2|102839-03-2|D12-prostaglandin J2|9-Deoxy-delta(9), delta(12)-13,14-dihydroprostaglandin D2| Specifications & Purity Moligand™, ≥98%, A solution in methyl acetate Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type AGONIST Mechanism of action Agonist of DP 1 receptor;Agonist of DP 2 receptor Product Description δ12-PGJ2 (δ12-Prostaglandin J2) is a decomposition product of PGD2 that has shown potent antiviral and anit-proliferative activity. This compound has also been shown to induce apoptosis, and to inhibit phosphoinositide turnover. Conjugation with glutathione is thought to enhance the cytotoxicity of δ12-PGJ2. Similar to other prostaglandins, it is often difficult to distinguish between biological activities derived directly from ′parent′ molecules and those derived from metabolites thereof.
Names and Identifiers IUPAC Name (Z)-7-[(1S,5E)-5-[(3S)-3-hydroxyoctylidene]-4-oxocyclopent-2-en-1-yl]hept-5-enoic acid INCHI InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/b7-4-,18-14+/t16-,17-/m0/s1 InChi Key TUXFWOHFPFBNEJ-GJGHEGAFSA-N Canonical SMILES CCCCCC(CC=C1C(C=CC1=O)CC=CCCCC(=O)O)O Isomeric SMILES CCCCC[C@@H](C/C=C/1\[C@H](C=CC1=O)C/C=C\CCCC(=O)O)O PubChem CID 5280885 Molecular Weight 334.5
Chemical and Physical Properties Solubility Soluble in ethanol (>25 mg/ml), DMSO (>25 mg/ml), and acetone. Refractive Index n20D1.56
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