Click Here for 5% Off Your First Aladdin Purchase!

Dasabuvir (ABT-333) - 98%, high purity , CAS No.1132935-63-7

  • Moligand™
  • ≥98%
Item Number
D413282
Grouped product items
SKUSizeAvailabilityPrice Qty
D413282-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$64.90
D413282-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$97.90
D413282-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$220.90
D413282-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$293.90
D413282-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$489.90

HCV Protease Inhibitors

Basic Description

SynonymsDasabuvir|1132935-63-7|ABT-333|N-(6-(3-(tert-butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide|ABT333|Dasabuvir [INN]|Dasabuvir (ABT-333)|CHEBI:85182|ABT 333|Dasabuvir sodium monohydrate|N-(6-(3-tert-But
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsDasabuvir (ABT-333) is a non-nucleoside inhibitor of NS5B viral RNA-dependent RNA polymerase that inhibits recombinant NS5B polymerases derived from HCV genotype 1a and 1b clinical isolates with IC50 values between 2.2 and 10.7 nM. It is at least 7,000-fo
Storage TempStore at -20°C,Argon charged
Shipped InIce chest + Ice pads
GradeMoligand™
Product Description

Information

Dasabuvir (ABT-333) Dasabuvir (ABT-333) is a non-nucleoside inhibitor of NS5B viral RNA-dependent RNA polymerase that inhibits recombinant NS5B polymerases derived from HCV genotype 1a and 1b clinical isolates with IC50 values between 2.2 and 10.7 nM. It is at least 7,000-fold selective for the inhibition of HCV genotype 1 polymerases over human/mammalian polymerases.

Product Properties

ALogP3.492
HBD Count2
Rotatable Bond6

Associated Targets

CRBN Tclin Protein cereblon 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name N-[6-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]naphthalen-2-yl]methanesulfonamide
INCHI InChI=1S/C26H27N3O5S/c1-26(2,3)22-15-20(29-11-10-23(30)27-25(29)31)14-21(24(22)34-4)18-7-6-17-13-19(28-35(5,32)33)9-8-16(17)12-18/h6-15,28H,1-5H3,(H,27,30,31)
InChi Key NBRBXGKOEOGLOI-UHFFFAOYSA-N
Canonical SMILES CC(C)(C)C1=CC(=CC(=C1OC)C2=CC3=C(C=C2)C=C(C=C3)NS(=O)(=O)C)N4C=CC(=O)NC4=O
Isomeric SMILES CC(C)(C)C1=CC(=CC(=C1OC)C2=CC3=C(C=C2)C=C(C=C3)NS(=O)(=O)C)N4C=CC(=O)NC4=O
PubChem CID 56640146
Molecular Weight 493.57

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

5 results found

Lot NumberCertificate TypeDateItem
G2219458Certificate of AnalysisJun 09, 2022 D413282
G2219459Certificate of AnalysisJun 09, 2022 D413282
G2219460Certificate of AnalysisJun 09, 2022 D413282
G2219461Certificate of AnalysisJun 09, 2022 D413282
G2219462Certificate of AnalysisJun 09, 2022 D413282

Chemical and Physical Properties

SolubilitySolubility (25°C) In vitro DMSO: 98 mg/mL (198.55 mM); Water: Insoluble; Ethanol: Insoluble;
SensitivityMoisture sensitive
DMSO(mg / mL) Max Solubility98
DMSO(mM) Max Solubility198.553396681322
Water(mg / mL) Max Solubility<1
Melt Point(°C)>192ºC

Related Documents

References

1. Stedman CA.  (2013)  Current prospects for interferon-free treatment of hepatitis C in 2012..  J Gastroenterol Hepatol,  28  (1): (38-45).  [PMID:23137126]

Solution Calculators