Basic Information
ID: ALA1028693
Type: Functional
Description: Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptake
Organism: Homo sapiens
Cell type: THP-1
Activity Charts
Bioactivity
Activity Types for Assay ALA1028693
Kd
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 289.85 | 4.65 | 4.65 |
| 463.52 | 4.73 | 4.73 |
| 445.52 | 5.05 | 5.05 |
| 317.86 | 4.63 | 4.63 |
| 338.28 | 4.94 | 4.94 |
| 303.83 | 4.29 | 4.29 |
| 303.83 | 4.29 | 4.29 |
| 445.48 | 4.19 | 4.19 |
| 333.86 | 4.29 | 4.29 |
| 303.83 | 4.89 | 4.89 |
| 317.86 | 4.68 | 4.68 |
| 283.41 | 4.54 | 4.54 |
| 338.28 | 4.94 | 4.94 |
| 313.44 | 4.55 | 4.55 |
| 313.44 | 4.55 | 4.55 |
| 338.28 | 4.94 | 4.94 |
| 540.32 | 7.05 | 7.05 |
| 289.81 | 4.04 | 4.04 |
| 459.50 | 4.58 | 4.58 |
| 319.20 | 4.00 | 4.00 |
| 306.16 | 3.09 | 3.09 |
| 339.71 | 3.46 | 3.46 |
| 339.71 | 3.32 | 3.32 |
| 318.21 | 4.61 | 4.61 |
| 397.29 | 3.59 | 3.59 |
| 389.29 | 4.18 | 4.18 |
| 319.20 | 4.63 | 4.63 |
| 389.29 | 4.18 | 4.18 |
| 474.57 | 3.82 | 3.82 |
| 321.42 | 3.89 | 3.89 |
| 458.48 | 4.04 | 4.04 |
| 403.95 | 3.81 | 3.81 |
| 405.97 | 3.15 | 3.15 |
| 435.61 | 4.60 | 4.60 |
| 375.90 | 4.59 | 4.59 |
| 481.02 | 3.39 | 3.39 |
| 441.96 | 4.25 | 4.25 |
| 422.57 | 3.77 | 3.77 |
| 492.58 | 5.13 | 5.13 |
| 405.24 | 2.20 | 2.20 |
| 269.39 | 4.23 | 4.23 |
| 423.94 | 5.65 | 5.65 |
| 421.97 | 3.03 | 3.03 |
| 388.94 | 3.09 | 3.09 |
| 302.81 | 4.20 | 4.20 |
| 428.92 | 4.00 | 4.00 |
| 392.84 | 1.39 | 1.39 |
| 424.81 | 3.85 | 3.85 |
| 270.38 | 3.51 | 3.51 |
| 374.06 | 5.00 | 5.00 |
| 435.01 | 4.03 | 4.03 |
| 404.98 | 3.75 | 3.75 |
| 417.00 | 4.09 | 4.09 |
| 402.97 | 3.61 | 3.61 |
| 482.02 | 5.14 | 5.14 |
| 421.45 | 4.39 | 4.39 |
| 421.89 | 3.38 | 3.38 |
| 338.84 | 5.33 | 5.33 |
| 422.57 | 4.74 | 4.74 |
| 438.83 | 4.41 | 4.41 |
| 438.81 | 5.33 | 5.33 |
| 455.05 | 4.77 | 4.77 |
| 497.08 | 4.54 | 4.54 |
| 525.09 | 4.87 | 4.87 |
| 282.39 | 4.39 | 4.39 |
| 407.54 | 3.60 | 3.60 |
| 449.86 | 4.39 | 4.39 |
| 367.49 | 3.83 | 3.83 |
| 449.40 | 2.85 | 2.85 |
| 449.45 | 3.66 | 3.66 |
| 419.95 | 3.37 | 3.37 |
| 376.93 | 3.54 | 3.54 |
| 424.93 | 5.05 | 5.05 |
| 393.53 | 4.57 | 4.57 |
| 549.12 | 4.15 | 4.15 |
| 405.45 | 4.17 | 4.17 |
| 401.89 | 4.52 | 4.52 |
| 479.46 | 2.73 | 2.73 |
| 414.89 | 2.52 | 2.52 |
| 410.51 | 3.07 | 3.07 |
| 436.41 | 4.20 | 4.20 |
| 390.95 | 3.41 | 3.41 |
| 470.01 | 5.40 | 5.40 |
| 435.48 | 4.74 | 4.74 |
| 463.80 | 5.18 | 5.18 |
| 378.86 | 2.52 | 2.52 |
| 378.82 | 1.00 | 1.00 |
| 502.62 | 1.97 | 1.97 |
| 419.57 | 4.30 | 4.30 |
| 442.80 | 3.99 | 3.99 |
| 388.94 | 3.09 | 3.09 |
| 474.99 | 6.20 | 6.20 |
| 413.93 | 4.19 | 4.19 |
| 395.84 | 3.80 | 3.80 |