Basic Information
ID: ALA1046106
Type: Functional
Description: Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HEK293
Target: Calcitonin gene-related peptide type 1 receptor(ALA3798)
Document: ALA1156095
Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production after 5 mins in presence of 50% human serum by scintillation proximity assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA1046106
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 566.53 | 3.69 | 3.69 |
| 527.49 | 3.27 | 3.27 |
| 566.53 | 4.86 | 4.86 |
| 567.52 | 4.26 | 4.26 |
| 541.52 | 3.58 | 3.58 |
| 517.46 | 1.99 | 1.99 |
| 577.55 | 3.72 | 3.72 |
| 578.58 | 4.65 | 4.65 |
| 565.54 | 4.08 | 4.08 |
| 551.52 | 3.69 | 3.69 |
| 516.47 | 2.44 | 2.44 |