Basic Information
ID: ALA1057688
Type: Binding
Description: Inhibition of human glutaminyl cyclase overexpressed in HEK293 cells coexpressing amyloid precursor protein assessed as reduction in pGlu-Abeta-3(pE)-40,42 peptide formation at 1 uM relative to 1-(3-(1H-imidazol-1-yl)propyl)-3-(3,4-dimethoxyphenyl)thiourea
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HEK293
Target: Glutaminyl-peptide cyclotransferase(ALA4508)
Document: ALA1154666
Inhibition of human glutaminyl cyclase overexpressed in HEK293 cells coexpressing amyloid precursor protein assessed as reduction in pGlu-Abeta-3(pE)-40,42 peptide formation at 1 uM relative to 1-(3-(1H-imidazol-1-yl)propyl)-3-(3,4-dimethoxyphenyl)thiourea: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA1057688
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 345.47 | 2.94 | 2.94 |
| 346.53 | 3.73 | 3.73 |
| 332.50 | 3.43 | 3.43 |
| 286.40 | 2.79 | 2.79 |
| 286.40 | 2.79 | 2.79 |
| 358.45 | 3.79 | 3.79 |
| 382.56 | 4.45 | 4.45 |
| 334.45 | 2.59 | 2.59 |
| 340.39 | 1.89 | 1.89 |
| 372.43 | 2.15 | 2.15 |
| 307.40 | 2.17 | 2.17 |
| 335.80 | 3.01 | 3.01 |
| 359.39 | 2.13 | 2.13 |
| 340.39 | 1.89 | 1.89 |
| 359.39 | 2.13 | 2.13 |
| 334.45 | 2.59 | 2.59 |
| 359.50 | 3.25 | 3.25 |
| 310.41 | 2.74 | 2.74 |