Basic Information
ID: ALA1100258
Type: Binding
Description: Inhibition of Trypanosoma cruzi trans-sialidase containing catalytic domain (N58F, R200K) and lectin-like domain (S495 K, V496G, E520K, D593G, I597D, H599R) mutation expressed in Escherichia coli JM109 assessed as MuNANA substrate hydrolysis in presence of 0.1% Triton X-100 by discontinuous fluorimetric assay
Organism: Trypanosoma cruzi
Activity Charts
Bioactivity
Activity Types for Assay ALA1100258
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 270.24 | 2.58 | 2.58 |
| 270.24 | 2.58 | 2.58 |
| 270.24 | 2.58 | 2.58 |
| 302.24 | 1.99 | 1.99 |
| 254.24 | 2.87 | 2.87 |
| 238.24 | 3.17 | 3.17 |
| 286.24 | 2.28 | 2.28 |
| 286.24 | 2.28 | 2.28 |
| 270.24 | 1.89 | 1.89 |
| 284.22 | 1.57 | 1.57 |
| 240.21 | 1.87 | 1.87 |
| 286.24 | 2.28 | 2.28 |
| 254.24 | 2.87 | 2.87 |
| 318.24 | 1.69 | 1.69 |
| 290.27 | 1.55 | 1.55 |
| 284.27 | 2.88 | 2.88 |
| 270.24 | 2.58 | 2.58 |
| 284.27 | 2.88 | 2.88 |
| 302.24 | 1.99 | 1.99 |
| 286.28 | 2.81 | 2.81 |
| 254.24 | 2.87 | 2.87 |
| 252.22 | 2.16 | 2.16 |
| 334.67 | 1.93 | 1.93 |