Basic Information
ID: ALA1106724
Type: Binding
Description: Inhibition of human 17beta-HSD7 expressed in HEK293 cells assessed as inhibition of reduction of [14C]estrone into [14C]estradiol at 0.3 uM after 7 hrs
Organism: Homo sapiens
Cell type: HEK293
Activity Charts
Bioactivity
Activity Types for Assay ALA1106724
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 270.24 | 2.58 | 2.58 |
| 292.21 | 2.32 | 2.32 |
| 371.52 | 6.00 | 6.00 |
| 360.45 | 1.85 | 1.85 |
| 314.47 | 4.72 | 4.72 |
| 254.24 | 2.87 | 2.87 |
| 272.39 | 3.61 | 3.61 |
| 296.41 | 3.61 | 3.61 |
| 372.55 | 3.81 | 3.81 |
| 290.45 | 3.96 | 3.96 |
| 290.45 | 3.67 | 3.67 |
| 268.22 | 3.10 | 3.10 |
| 272.39 | 3.61 | 3.61 |
| 276.21 | 3.21 | 3.21 |
| 457.57 | 6.03 | 6.03 |
| 625.81 | 8.52 | 8.52 |
| 290.45 | 3.96 | 3.96 |
| 292.46 | 3.75 | 3.75 |
| 330.47 | 3.84 | 3.84 |
| 288.43 | 3.88 | 3.88 |
| 268.36 | 3.74 | 3.74 |
| 346.47 | 2.67 | 2.67 |
| 270.37 | 3.53 | 3.53 |
| 302.41 | 3.97 | 3.97 |
| 292.46 | 3.75 | 3.75 |
| 606.78 | 8.68 | 8.68 |
| 300.40 | 3.83 | 3.83 |
| 288.39 | 2.58 | 2.58 |
| 416.58 | 4.85 | 4.85 |
| 293.37 | 2.93 | 2.93 |
| 270.37 | 3.82 | 3.82 |
| 288.43 | 3.88 | 3.88 |
| 362.47 | 1.78 | 1.78 |
| 266.34 | 3.94 | 3.94 |
| 346.47 | 2.81 | 2.81 |
| 330.47 | 3.70 | 3.70 |
| 316.49 | 4.52 | 4.52 |
| 256.39 | 4.64 | 4.64 |
| 332.48 | 3.63 | 3.63 |
| 290.45 | 3.96 | 3.96 |
| 292.46 | 3.75 | 3.75 |
| 395.54 | 4.74 | 4.74 |
| 340.46 | 4.71 | 4.71 |
| 382.54 | 5.74 | 5.74 |
| 326.44 | 4.32 | 4.32 |
| 354.49 | 4.96 | 4.96 |
| 368.52 | 5.35 | 5.35 |
| 354.49 | 4.96 | 4.96 |
| 324.46 | 5.01 | 5.01 |
| 268.36 | 3.73 | 3.73 |
| 436.64 | 5.38 | 5.38 |
| 388.60 | 4.38 | 4.38 |
| 429.65 | 4.80 | 4.80 |
| 427.63 | 4.58 | 4.58 |
| 518.18 | 7.04 | 7.04 |
| 379.34 | 4.62 | 4.62 |
| 469.71 | 5.73 | 5.73 |
| 467.70 | 5.50 | 5.50 |
| 429.65 | 4.80 | 4.80 |
| 427.63 | 4.58 | 4.58 |
| 448.50 | 5.12 | 5.12 |
| 403.61 | 4.27 | 4.27 |
| 443.68 | 5.19 | 5.19 |
| 347.54 | 4.38 | 4.38 |
| 345.53 | 4.16 | 4.16 |
| 402.62 | 4.77 | 4.77 |
| 484.68 | 6.57 | 6.57 |
| 497.46 | 4.80 | 4.80 |
| 385.55 | 4.39 | 4.39 |
| 389.61 | 5.12 | 5.12 |
| 405.67 | 5.92 | 5.92 |
| 425.57 | 5.24 | 5.24 |
| 344.50 | 3.11 | 3.11 |
| 390.01 | 6.21 | 6.21 |
| 493.57 | 6.26 | 6.26 |
| 563.66 | 6.83 | 6.83 |
| 480.69 | 5.92 | 5.92 |
| 348.91 | 5.47 | 5.47 |
| 512.82 | 7.60 | 7.60 |
| 459.57 | 6.03 | 6.03 |
| 386.58 | 5.70 | 5.70 |
| 254.37 | 4.41 | 4.41 |
| 333.45 | 2.76 | 2.76 |
| 363.48 | 2.77 | 2.77 |
| 511.73 | 5.47 | 5.47 |
| 394.60 | 5.96 | 5.96 |
| 509.82 | 7.11 | 7.11 |
| 380.57 | 5.57 | 5.57 |
| 358.52 | 5.06 | 5.06 |
| 354.49 | 4.96 | 4.96 |
| 612.85 | 6.00 | 6.00 |
| 555.25 | 8.07 | 8.07 |
| 506.78 | 7.33 | 7.33 |
| 585.67 | 8.09 | 8.09 |
| 430.68 | 5.65 | 5.65 |
| 541.22 | 7.98 | 7.98 |
| 604.80 | 8.36 | 8.36 |
| 541.22 | 7.98 | 7.98 |
| 575.67 | 8.64 | 8.64 |
| 524.77 | 7.47 | 7.47 |
| 555.25 | 8.07 | 8.07 |
| 531.79 | 7.20 | 7.20 |
| 627.75 | 9.26 | 9.26 |
| 583.30 | 9.15 | 9.15 |
| 646.88 | 9.53 | 9.53 |
| 583.30 | 9.15 | 9.15 |
| 617.75 | 9.81 | 9.81 |
| 566.85 | 8.64 | 8.64 |
| 597.33 | 9.24 | 9.24 |
| 597.33 | 9.24 | 9.24 |
| 573.87 | 8.37 | 8.37 |
| 655.81 | 10.04 | 10.04 |
| 611.36 | 9.94 | 9.94 |
| 674.93 | 10.31 | 10.31 |
| 611.36 | 9.94 | 9.94 |
| 645.80 | 10.59 | 10.59 |
| 594.90 | 9.42 | 9.42 |
| 625.38 | 10.02 | 10.02 |
| 625.38 | 10.02 | 10.02 |
| 601.92 | 9.15 | 9.15 |
| 542.76 | 7.61 | 7.61 |
| 542.76 | 7.61 | 7.61 |
| 542.76 | 7.61 | 7.61 |
| 542.76 | 7.61 | 7.61 |
| 596.73 | 8.03 | 8.03 |
| 592.76 | 8.49 | 8.49 |
| 562.88 | 8.63 | 8.63 |
| 604.96 | 9.84 | 9.84 |
| 632.67 | 7.94 | 7.94 |
| 584.84 | 8.78 | 8.78 |
| 584.84 | 8.78 | 8.78 |
| 584.84 | 8.78 | 8.78 |
| 584.84 | 8.78 | 8.78 |
| 638.81 | 9.20 | 9.20 |
| 634.84 | 9.66 | 9.66 |
| 604.96 | 9.80 | 9.80 |
| 647.04 | 11.01 | 11.01 |
| 674.75 | 9.11 | 9.11 |
| 410.55 | 5.43 | 5.43 |
| 396.57 | 6.04 | 6.04 |
| 332.48 | 3.92 | 3.92 |
| 472.63 | 6.86 | 6.86 |
| 396.53 | 5.34 | 5.34 |
| 460.64 | 5.37 | 5.37 |
| 508.68 | 6.41 | 6.41 |
| 348.48 | 2.89 | 2.89 |
| 364.48 | 1.86 | 1.86 |
| 426.60 | 5.67 | 5.67 |
| 423.60 | 5.35 | 5.35 |
| 377.53 | 5.52 | 5.52 |
| 557.62 | 7.31 | 7.31 |
| 458.78 | 7.29 | 7.29 |
| 492.79 | 7.69 | 7.69 |
| 411.61 | 5.28 | 5.28 |
| 437.41 | 6.66 | 6.66 |
| 411.54 | 4.45 | 4.45 |
| 426.55 | 5.14 | 5.14 |
| 498.84 | 8.07 | 8.07 |
| 494.41 | 5.95 | 5.95 |
| 396.57 | 6.13 | 6.13 |
| 388.60 | 4.52 | 4.52 |
| 470.66 | 6.22 | 6.22 |
| 288.43 | 3.88 | 3.88 |
| 372.55 | 3.84 | 3.84 |
| 382.50 | 4.53 | 4.53 |
| 346.52 | 3.31 | 3.31 |
| 374.57 | 4.09 | 4.09 |
| 416.65 | 5.26 | 5.26 |
| 284.40 | 3.86 | 3.86 |
| 414.63 | 5.01 | 5.01 |
| 422.61 | 4.88 | 4.88 |
| 372.55 | 3.84 | 3.84 |
| 458.73 | 6.43 | 6.43 |
| 453.62 | 5.20 | 5.20 |
| 387.52 | 5.70 | 5.70 |