Basic Information
ID: ALA1120421
Type: Functional
Description: Antagonist activity at NK2 receptor in Dunkin-Hartley guinea pig colon smooth muscle assessed as inhibition of [beta-Ala8]NKA(4-10)-induced tissue contraction in presence of NK1 receptor antagonist SR-140333
Format: BAO_0000221
Organism: Cavia porcellus
Strain: Dunkin-Hartley
Tissue: Colon
Target: Neurokinin 2 receptor(ALA2647)
Document: ALA1155466
Antagonist activity at NK2 receptor in Dunkin-Hartley guinea pig colon smooth muscle assessed as inhibition of [beta-Ala8]NKA(4-10)-induced tissue contraction in presence of NK1 receptor antagonist SR-140333: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA1120421
pKb
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 650.91 | 6.26 | 6.26 |
| 636.88 | 5.95 | 5.95 |
| 610.84 | 5.43 | 5.43 |
| 600.80 | 5.03 | 5.03 |
| 635.25 | 5.68 | 5.68 |
| 630.83 | 5.04 | 5.04 |
| 614.83 | 5.34 | 5.34 |
| 616.87 | 5.50 | 5.50 |
| 630.90 | 5.80 | 5.80 |
| 395.98 | 1.91 | 1.91 |
| 630.90 | 5.80 | 5.80 |
| 630.90 | 5.80 | 5.80 |
| 602.84 | 5.17 | 5.17 |
| 616.87 | 5.56 | 5.56 |
| 630.90 | 5.95 | 5.95 |
| 644.93 | 6.34 | 6.34 |
| 575.82 | 5.85 | 5.85 |
| 602.85 | 5.17 | 5.17 |
| 602.85 | 5.02 | 5.02 |
| 644.88 | 5.33 | 5.33 |
| 628.88 | 5.58 | 5.58 |
| 629.91 | 7.29 | 7.29 |
| 631.88 | 6.14 | 6.14 |
| 645.91 | 6.53 | 6.53 |
| 616.87 | 5.56 | 5.56 |
| 609.84 | 5.98 | 5.98 |
| 610.83 | 5.37 | 5.37 |
| 640.87 | 6.72 | 6.72 |
| 623.87 | 5.97 | 5.97 |
| 623.87 | 5.97 | 5.97 |
| 623.87 | 5.97 | 5.97 |
| 628.91 | 6.64 | 6.64 |
| 628.91 | 6.64 | 6.64 |
| 612.84 | 6.17 | 6.17 |
| 612.84 | 5.30 | 5.30 |
| 628.85 | 4.10 | 4.10 |
| 618.89 | 5.80 | 5.80 |
| 644.88 | 5.33 | 5.33 |
| 639.87 | 5.56 | 5.56 |
| 560.76 | 4.53 | 4.53 |
| 645.87 | 4.83 | 4.83 |
| 681.93 | 3.95 | 3.95 |
| 639.89 | 4.18 | 4.18 |
| 611.83 | 3.58 | 3.58 |
| 638.90 | 5.12 | 5.12 |
| 624.87 | 4.73 | 4.73 |
| 672.94 | 5.09 | 5.09 |