Basic Information
ID: ALA1217334
Type: Binding
Description: Inhibition of human recombinant Top1-mediated DNA cleavage at 0.1 to 100 uM after 20 mins relative to camptothecin
Format: BAO_0000357
Organism: Homo sapiens
Target: DNA topoisomerase I(ALA1781)
Document: ALA1212854
Inhibition of human recombinant Top1-mediated DNA cleavage at 0.1 to 100 uM after 20 mins relative to camptothecin: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA1217334
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 284.32 | 3.58 | 3.58 |
| 478.50 | 2.68 | 2.68 |
| 459.46 | 3.25 | 3.25 |
| 399.45 | 3.41 | 3.41 |
| 422.44 | 3.59 | 3.59 |
| 441.49 | 3.18 | 3.18 |
| 415.45 | 2.43 | 2.43 |
| 441.49 | 2.92 | 2.92 |
| 443.50 | 2.86 | 2.86 |
| 450.50 | 4.18 | 4.18 |
| 469.54 | 3.61 | 3.61 |
| 440.50 | 3.05 | 3.05 |
| 401.42 | 2.39 | 2.39 |
| 427.46 | 2.87 | 2.87 |
| 465.51 | 3.68 | 3.68 |
| 428.51 | 3.77 | 3.77 |
| 453.52 | 4.40 | 4.40 |
| 389.43 | 3.11 | 3.11 |
| 430.94 | 3.98 | 3.98 |
| 417.90 | 3.80 | 3.80 |
| 391.86 | 3.31 | 3.31 |
| 398.85 | 4.48 | 4.48 |
| 455.95 | 4.61 | 4.61 |
| 430.94 | 3.98 | 3.98 |
| 467.40 | 3.98 | 3.98 |
| 454.36 | 3.80 | 3.80 |
| 492.41 | 4.61 | 4.61 |
| 390.83 | 4.09 | 4.09 |
| 568.55 | 3.10 | 3.10 |
| 498.58 | 3.16 | 3.16 |
| 427.50 | 3.84 | 3.84 |
| 479.54 | 3.73 | 3.73 |
| 443.50 | 3.16 | 3.16 |
| 415.47 | 3.59 | 3.59 |
| 417.90 | 3.80 | 3.80 |
| 398.85 | 4.48 | 4.48 |
| 455.95 | 4.61 | 4.61 |
| 418.88 | 4.52 | 4.52 |
| 385.42 | 3.37 | 3.37 |
| 392.84 | 4.33 | 4.33 |
| 424.46 | 3.84 | 3.84 |
| 456.55 | 3.34 | 3.34 |
| 481.56 | 3.97 | 3.97 |
| 472.37 | 3.24 | 3.24 |
| 418.30 | 3.48 | 3.48 |