Basic Information
ID: ALA1613908
Type: Functional
Description: PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay to identify inhibitors of cyclic nucleotide gated ion channel (CNGC) activity. In this assay, the parental HEK293 cell line transfected with a cyclic-nucleotide gated ion channel (CNGC)-based cAMP sensor is used to measure inhibition of isoproterenol-induced CNGC activity by test compound. (Class of assay: confirmatory) [Related pubchem assays: 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]
Organism: Homo sapiens
Cell type: HEK293
Activity Charts
Bioactivity
Activity Types for Assay ALA1613908
EC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 406.91 | 6.61 | 6.61 |
| 308.29 | 3.71 | 3.71 |
| 296.41 | 3.50 | 3.50 |
| 356.52 | 5.05 | 5.05 |
| 433.53 | 5.22 | 5.22 |
| 270.76 | 2.02 | 2.02 |
| 499.62 | 4.16 | 4.16 |
| 512.20 | 4.89 | 4.89 |
| 498.27 | 5.64 | 5.64 |
| 384.44 | 5.29 | 5.29 |
| 431.56 | 3.59 | 3.59 |
| 278.74 | 2.75 | 2.75 |
| 219.33 | 1.57 | 1.57 |
| 313.72 | 2.72 | 2.72 |
| 423.90 | 2.17 | 2.17 |
| 527.02 | 7.03 | 7.03 |
| 414.51 | 3.84 | 3.84 |
| 442.52 | 3.61 | 3.61 |
| 451.94 | 5.32 | 5.32 |
| 347.32 | 3.37 | 3.37 |
| 259.26 | 1.98 | 1.98 |
| 472.41 | 6.14 | 6.14 |
| 220.18 | 2.08 | 2.08 |
| 431.95 | 5.94 | 5.94 |
| 330.39 | 3.84 | 3.84 |
| 321.63 | 4.29 | 4.29 |
| 337.45 | 4.52 | 4.52 |
| 426.52 | 4.71 | 4.71 |
| 378.88 | 3.26 | 3.26 |
| 445.94 | 3.86 | 3.86 |
| 487.97 | 3.48 | 3.48 |
| 378.43 | 1.56 | 1.56 |
| 399.48 | 2.13 | 2.13 |
| 407.43 | 3.41 | 3.41 |
| 271.27 | 0.40 | 0.40 |
| 441.51 | 2.46 | 2.46 |
| 428.44 | 4.03 | 4.03 |
| 288.26 | 2.09 | 2.09 |
| 370.08 | 4.18 | 4.18 |
| 358.43 | 2.90 | 2.90 |
| 373.80 | 3.74 | 3.74 |
| 317.34 | 2.97 | 2.97 |
| 480.98 | 5.21 | 5.21 |
| 251.28 | 4.06 | 4.06 |
| 258.30 | 0.62 | 0.62 |
| 365.39 | 3.82 | 3.82 |
| 356.20 | 3.33 | 3.33 |
| 322.32 | 3.26 | 3.26 |
| 347.42 | 3.40 | 3.40 |
| 356.64 | 4.88 | 4.88 |
| 569.60 | 4.83 | 4.83 |
| 287.83 | 2.43 | 2.43 |
| 464.35 | 4.87 | 4.87 |
| 408.46 | 3.31 | 3.31 |
| 198.27 | 3.25 | 3.25 |
| 452.72 | 6.24 | 6.24 |
| 293.30 | 4.48 | 4.48 |
| 242.31 | 2.60 | 2.60 |
| 268.27 | 2.61 | 2.61 |
| 359.45 | 3.08 | 3.08 |
| 299.84 | 2.47 | 2.47 |
| 356.38 | 3.88 | 3.88 |
| 311.77 | 4.76 | 4.76 |
| 368.36 | 2.85 | 2.85 |
| 328.21 | 3.94 | 3.94 |
| 366.51 | 3.29 | 3.29 |
| 413.86 | ||
| 344.42 | 3.57 | 3.57 |
| 382.42 | 3.07 | 3.07 |
| 174.62 | 0.95 | 0.95 |
| 344.42 | 3.33 | 3.33 |
| 312.35 | 2.23 | 2.23 |
| 467.40 | 1.70 | 1.70 |
| 418.88 | 4.46 | 4.46 |
| 462.89 | 4.00 | 4.00 |
| 552.05 | 4.71 | 4.71 |
| 288.25 | 2.16 | 2.16 |
| 528.65 | 3.83 | 3.83 |
| 684.82 | 1.61 | 1.61 |
| 291.31 | 2.70 | 2.70 |
| 454.50 | 4.41 | 4.41 |
| 283.72 | 3.51 | 3.51 |
| 445.87 | 4.65 | 4.65 |
| 513.94 | 3.11 | 3.11 |
| 417.44 | 4.36 | 4.36 |
| 439.44 | 2.07 | 2.07 |
| 482.97 | 5.37 | 5.37 |
| 273.34 | 3.53 | 3.53 |
| 444.16 | 4.14 | 4.14 |