Basic Information
ID: ALA1613925
Type: Functional
Description: PUBCHEM_BIOASSAY: HCS for Compounds that Down-Regulate Insulin Promoter Activity in MIN6 Cells. High Content Screening for Compounds that Down-Regulate Insulin Promoter Activity in MIN6 Cells (engineered to stably express an insulin promoter-eGFP reporter transgene which mimics the activity of the endogenous insulin gene). The GFP-activity is determined using image-based high-content screening assay read-outs Only raw primary screen data available. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1647, AID2122]
Organism: Mus musculus
Activity Charts
Bioactivity
Activity Types for Assay ALA1613925
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 308.29 | 3.71 | 3.71 |
| 233.27 | 3.21 | 3.21 |
| 194.24 | 2.97 | 2.97 |
| 276.29 | 4.10 | 4.10 |
| 464.56 | 6.29 | 6.29 |
| 434.54 | 4.11 | 4.11 |
| 237.26 | 3.08 | 3.08 |
| 370.82 | 4.72 | 4.72 |
| 324.81 | 4.79 | 4.79 |
| 320.40 | 4.15 | 4.15 |
| 283.33 | 2.91 | 2.91 |
| 410.43 | 1.58 | 1.58 |
| 350.42 | 3.95 | 3.95 |
| 314.39 | 4.76 | 4.76 |
| 350.42 | 3.95 | 3.95 |
| 290.37 | 4.14 | 4.14 |
| 384.43 | 4.51 | 4.51 |
| 351.41 | 3.82 | 3.82 |
| 349.83 | 3.12 | 3.12 |
| 487.58 | 2.59 | 2.59 |
| 307.31 | 4.13 | 4.13 |
| 334.43 | 1.99 | 1.99 |
| 351.36 | 1.89 | 1.89 |
| 352.82 | 4.58 | 4.58 |
| 451.19 | 4.16 | 4.16 |
| 387.32 | 3.96 | 3.96 |
| 329.49 | 3.68 | 3.68 |
| 325.42 | 3.39 | 3.39 |
| 336.39 | 3.53 | 3.53 |
| 468.65 | 5.91 | 5.91 |
| 432.52 | 3.01 | 3.01 |
| 446.96 | 3.01 | 3.01 |
| 417.47 | 3.17 | 3.17 |
| 365.43 | 4.21 | 4.21 |
| 475.29 | 4.38 | 4.38 |
| 229.30 | 3.90 | 3.90 |
| 340.39 | 5.86 | 5.86 |
| 367.45 | 4.08 | 4.08 |
| 436.31 | 4.27 | 4.27 |
| 362.45 | 2.48 | 2.48 |
| 396.47 | 3.76 | 3.76 |
| 351.40 | 3.67 | 3.67 |
| 329.40 | 2.77 | 2.77 |
| 560.33 | 6.26 | 6.26 |
| 367.40 | 3.14 | 3.14 |
| 392.50 | 3.38 | 3.38 |
| 539.55 | 4.78 | 4.78 |
| 416.51 | 1.51 | 1.51 |
| 479.49 | 5.83 | 5.83 |
| 243.27 | 2.74 | 2.74 |
| 419.40 | 4.05 | 4.05 |
| 369.49 | 3.66 | 3.66 |
| 439.48 | 2.89 | 2.89 |
| 369.49 | 4.14 | 4.14 |
| 412.52 | 3.48 | 3.48 |
| 301.44 | 4.32 | 4.32 |
| 300.40 | 3.08 | 3.08 |
| 419.44 | 1.82 | 1.82 |
| 349.38 | 2.43 | 2.43 |
| 252.24 | 4.03 | 4.03 |
| 266.34 | 4.12 | 4.12 |
| 317.40 | 3.82 | 3.82 |
| 453.52 | 5.00 | 5.00 |
| 474.68 | 4.05 | 4.05 |
| 314.39 | 4.76 | 4.76 |
| 505.67 | 5.11 | 5.11 |
| 341.25 | 4.14 | 4.14 |
| 348.43 | 4.03 | 4.03 |
| 451.55 | 3.45 | 3.45 |
| 349.48 | 3.90 | 3.90 |
| 374.45 | 3.61 | 3.61 |
| 413.95 | 4.44 | 4.44 |
| 277.33 | 4.97 | 4.97 |
| 379.26 | 4.44 | 4.44 |
| 296.41 | 3.01 | 3.01 |
| 591.63 | 5.71 | 5.71 |
| 387.87 | 4.87 | 4.87 |
| 474.56 | 4.71 | 4.71 |
| 445.01 | 3.16 | 3.16 |
| 351.41 | 3.51 | 3.51 |
| 303.41 | 3.56 | 3.56 |
| 660.64 | ||
| 472.64 | 4.34 | 4.34 |
| 363.44 | 4.42 | 4.42 |
| 400.31 | 4.31 | 4.31 |
| 455.38 | 3.74 | 3.74 |
| 394.73 | 3.48 | 3.48 |
| 478.60 | 4.11 | 4.11 |
| 326.44 | 3.34 | 3.34 |
| 367.46 | 4.02 | 4.02 |
| 428.51 | 2.63 | 2.63 |
| 392.47 | 1.90 | 1.90 |
| 471.56 | 3.50 | 3.50 |
| 278.47 | 4.91 | 4.91 |
| 356.38 | 3.06 | 3.06 |
| 329.38 | 3.91 | 3.91 |
| 264.33 | 3.90 | 3.90 |
| 309.44 | 4.24 | 4.24 |
| 270.34 | 2.90 | 2.90 |
| 374.47 | 3.93 | 3.93 |
| 252.32 | 3.05 | 3.05 |
| 447.02 | 4.40 | 4.40 |
| 450.32 | 5.32 | 5.32 |
| 255.15 | 2.67 | 2.67 |
| 374.37 | 2.55 | 2.55 |
| 498.95 | 4.04 | 4.04 |
| 409.96 | 4.81 | 4.81 |
| 373.37 | 2.33 | 2.33 |
| 381.52 | 3.89 | 3.89 |
| 427.00 | 5.40 | 5.40 |
| 347.45 | 4.12 | 4.12 |
| 376.33 | 3.28 | 3.28 |
| 440.52 | 4.64 | 4.64 |
| 222.29 | 3.39 | 3.39 |
| 320.27 | 3.25 | 3.25 |
| 315.37 | 2.05 | 2.05 |
| 439.95 | 3.49 | 3.49 |
| 255.15 | 2.67 | 2.67 |
| 319.31 | 2.57 | 2.57 |
| 458.02 | 2.80 | 2.80 |
| 483.95 | 6.96 | 6.96 |
| 355.28 | 3.69 | 3.69 |
| 350.40 | 2.46 | 2.46 |
| 320.27 | 4.17 | 4.17 |
| 445.01 | 3.54 | 3.54 |
| 373.92 | 4.54 | 4.54 |
| 468.94 | 3.46 | 3.46 |
| 361.87 | 2.99 | 2.99 |
| 422.94 | 5.49 | 5.49 |
| 485.07 | 5.36 | 5.36 |
| 389.46 | 5.27 | 5.27 |
| 382.56 | 2.33 | 2.33 |
| 376.39 | 3.09 | 3.09 |
| 494.55 | 4.60 | 4.60 |
| 299.38 | 2.94 | 2.94 |
| 458.61 | 5.32 | 5.32 |
| 313.57 | 4.77 | 4.77 |
| 425.62 | 4.08 | 4.08 |
| 531.55 | 6.54 | 6.54 |
| 376.37 | 3.17 | 3.17 |
| 325.30 | 3.57 | 3.57 |
| 432.54 | 5.30 | 5.30 |
| 358.27 | 2.75 | 2.75 |
| 394.36 | 4.09 | 4.09 |
| 404.47 | 6.24 | 6.24 |
| 487.97 | 5.25 | 5.25 |
| 368.42 | 3.55 | 3.55 |
| 475.61 | 4.28 | 4.28 |
| 425.53 | 1.53 | 1.53 |
| 505.44 | 5.55 | 5.55 |
| 238.29 | 2.66 | 2.66 |
| 336.37 | 4.37 | 4.37 |
| 304.35 | 3.14 | 3.14 |
| 299.36 | 3.67 | 3.67 |
| 384.51 | 3.31 | 3.31 |
| 324.39 | 2.36 | 2.36 |
| 438.48 | 3.89 | 3.89 |
| 324.41 | 3.37 | 3.37 |
| 264.39 | 3.13 | 3.13 |
| 309.37 | 3.34 | 3.34 |
| 423.35 | 4.56 | 4.56 |
| 356.26 | 4.93 | 4.93 |
| 352.51 | 4.38 | 4.38 |
| 432.33 | 6.21 | 6.21 |
| 536.62 | 3.02 | 3.02 |
| 532.46 | 5.26 | 5.26 |
| 303.41 | 3.01 | 3.01 |
| 357.48 | 3.43 | 3.43 |
| 448.55 | 3.44 | 3.44 |
| 458.66 | 4.50 | 4.50 |
| 339.40 | 1.27 | 1.27 |
| 385.42 | 3.77 | 3.77 |
| 399.56 | 4.80 | 4.80 |
| 440.95 | 5.23 | 5.23 |
| 347.42 | 1.80 | 1.80 |
| 422.53 | 5.95 | 5.95 |
| 446.39 | 4.09 | 4.09 |
| 332.36 | 3.83 | 3.83 |
| 564.47 | 5.39 | 5.39 |
| 473.58 | 3.69 | 3.69 |
| 397.48 | 3.86 | 3.86 |
| 463.54 | 4.19 | 4.19 |
| 286.71 | 3.30 | 3.30 |
| 425.47 | 3.60 | 3.60 |
| 364.83 | 3.66 | 3.66 |
| 472.63 | 4.76 | 4.76 |
| 271.10 | 2.55 | 2.55 |
| 446.51 | 5.93 | 5.93 |
| 326.40 | 4.35 | 4.35 |
| 396.44 | 4.38 | 4.38 |
| 365.46 | 4.60 | 4.60 |
| 387.48 | 5.04 | 5.04 |
| 343.36 | 1.22 | 1.22 |
| 375.98 | 3.64 | 3.64 |
| 383.34 | 4.33 | 4.33 |
| 489.53 | 4.04 | 4.04 |
| 310.31 | 3.86 | 3.86 |
| 358.44 | 4.38 | 4.38 |
| 362.36 | 4.24 | 4.24 |
| 433.35 | 4.53 | 4.53 |
| 316.16 | 3.35 | 3.35 |
| 436.35 | 4.16 | 4.16 |
| 307.35 | 2.29 | 2.29 |
| 505.43 | 6.04 | 6.04 |
| 481.36 | 2.24 | 2.24 |
| 562.63 | 3.43 | 3.43 |
| 386.50 | 5.33 | 5.33 |
| 252.70 | 2.81 | 2.81 |
| 309.44 | 4.15 | 4.15 |
| 366.47 | 4.05 | 4.05 |
| 402.50 | 4.39 | 4.39 |
| 329.77 | 2.55 | 2.55 |
| 274.32 | 3.76 | 3.76 |
| 297.14 | 3.43 | 3.43 |
| 406.96 | 5.96 | 5.96 |
| 416.41 | 4.52 | 4.52 |
| 381.26 | 1.89 | 1.89 |
| 401.51 | 4.27 | 4.27 |
| 400.48 | 5.73 | 5.73 |
| 389.47 | 2.41 | 2.41 |
| 299.36 | 3.67 | 3.67 |
| 351.45 | 3.92 | 3.92 |
| 481.51 | 5.63 | 5.63 |
| 461.01 | 2.86 | 2.86 |
| 403.53 | 4.75 | 4.75 |
| 489.53 | 2.52 | 2.52 |
| 288.39 | 3.30 | 3.30 |
| 429.75 | 4.60 | 4.60 |
| 309.37 | 3.54 | 3.54 |
| 451.57 | 4.15 | 4.15 |
| 388.34 | 3.42 | 3.42 |
| 403.94 | 4.79 | 4.79 |
| 292.16 | 2.16 | 2.16 |
| 329.41 | 3.92 | 3.92 |
| 278.31 | 3.62 | 3.62 |
| 338.84 | 4.78 | 4.78 |
| 377.92 | 4.22 | 4.22 |
| 493.47 | 6.56 | 6.56 |
| 390.90 | 3.86 | 3.86 |
| 373.44 | 5.34 | 5.34 |
| 426.31 | 3.75 | 3.75 |
| 289.59 | 3.32 | 3.32 |
| 319.39 | 4.43 | 4.43 |
| 416.35 | 5.25 | 5.25 |
| 281.40 | 4.03 | 4.03 |
| 290.37 | 3.50 | 3.50 |
| 391.43 | 2.35 | 2.35 |
| 433.55 | 4.94 | 4.94 |
| 390.01 | 3.88 | 3.88 |
| 455.30 | 5.83 | 5.83 |
| 395.46 | 3.42 | 3.42 |
| 347.42 | 3.73 | 3.73 |
| 452.61 | 5.26 | 5.26 |
| 454.55 | 2.77 | 2.77 |
| 323.35 | 2.12 | 2.12 |
| 407.34 | 4.91 | 4.91 |
| 279.39 | 4.27 | 4.27 |
| 608.39 | 5.87 | 5.87 |
| 745.66 | 8.57 | 8.57 |
| 455.31 | 4.51 | 4.51 |
| 367.29 | 3.29 | 3.29 |
| 494.53 | 3.19 | 3.19 |
| 391.47 | 2.82 | 2.82 |
| 329.36 | 2.28 | 2.28 |
| 353.18 | 2.04 | 2.04 |
| 278.70 | 2.29 | 2.29 |
| 468.89 | 4.35 | 4.35 |
| 410.48 | 3.82 | 3.82 |
| 267.35 | 1.23 | 1.23 |
| 462.49 | 3.54 | 3.54 |
| 315.35 | 2.63 | 2.63 |
| 355.35 | 3.87 | 3.87 |
| 398.85 | 3.25 | 3.25 |
| 478.20 | 3.48 | 3.48 |
| 370.41 | 3.91 | 3.91 |
| 323.40 | 3.56 | 3.56 |
| 430.47 | 3.58 | 3.58 |
| 485.64 | 3.08 | 3.08 |
| 431.48 | 3.78 | 3.78 |
| 313.74 | 3.75 | 3.75 |
| 290.41 | 5.01 | 5.01 |
| 327.31 | 2.92 | 2.92 |
| 370.21 | 3.47 | 3.47 |
| 418.49 | 4.87 | 4.87 |
| 321.34 | 2.01 | 2.01 |
| 356.39 | 2.37 | 2.37 |
| 418.49 | 4.74 | 4.74 |
| 214.27 | 3.10 | 3.10 |
| 499.66 | 3.57 | 3.57 |
| 332.79 | 2.85 | 2.85 |
| 450.46 | 3.28 | 3.28 |
| 346.39 | 4.36 | 4.36 |
| 381.23 | 1.56 | 1.56 |
| 347.64 | 1.73 | 1.73 |
| 347.42 | 2.83 | 2.83 |
| 273.25 | 2.45 | 2.45 |
| 468.52 | 3.60 | 3.60 |
| 332.79 | 2.53 | 2.53 |