ID: ALA1614030
Type: Functional
Description: PUBCHEM_BIOASSAY: HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1579, AID1852, AID2337]
Organism: Homo sapiens
Cell type: HEK293
Bioactivity
Activity Types for Assay ALA1614030
IC50
Parent Molecular Weight | ALogP | Polar Surface Area |
---|---|---|
366.41 | 4.34 | 4.34 |
312.22 | 4.67 | 4.67 |
322.42 | 3.50 | 3.50 |
406.55 | 3.89 | 3.89 |
284.34 | 3.04 | 3.04 |
464.56 | 6.29 | 6.29 |
307.19 | 2.14 | 2.14 |
454.70 | 7.44 | 7.44 |
462.92 | 2.71 | 2.71 |
319.19 | 4.45 | 4.45 |
380.27 | 3.06 | 3.06 |
488.41 | 5.17 | 5.17 |
396.30 | 3.36 | 3.36 |
447.02 | 3.21 | 3.21 |
488.44 | 5.88 | 5.88 |
476.54 | 6.83 | 6.83 |
361.23 | 4.47 | 4.47 |
320.22 | 2.94 | 2.94 |
531.43 | 3.78 | 3.78 |
432.98 | 3.34 | 3.34 |
381.48 | 4.74 | 4.74 |
353.42 | 3.88 | 3.88 |
500.96 | 3.58 | 3.58 |
374.47 | 4.90 | 4.90 |
416.55 | 5.00 | 5.00 |
507.57 | 4.31 | 4.31 |
402.28 | 5.66 | 5.66 |
351.41 | 3.82 | 3.82 |
255.35 | 3.86 | 3.86 |
440.40 | 3.26 | 3.26 |
307.35 | 3.80 | 3.80 |
321.81 | 4.17 | 4.17 |
397.78 | 3.43 | 3.43 |
392.25 | 5.71 | 5.71 |
252.66 | 1.86 | 1.86 |
347.46 | 4.28 | 4.28 |
385.44 | 3.87 | 3.87 |
461.61 | 3.45 | 3.45 |
335.11 | 4.68 | 4.68 |
477.54 | 3.75 | 3.75 |
531.46 | 5.37 | 5.37 |
386.50 | 3.51 | 3.51 |
406.44 | 3.58 | 3.58 |
490.40 | 6.14 | 6.14 |
395.44 | 4.29 | 4.29 |
390.31 | 2.83 | 2.83 |
388.37 | 3.14 | 3.14 |
524.40 | 4.64 | 4.64 |
518.59 | 5.46 | 5.46 |
415.44 | 4.38 | 4.38 |
323.81 | 2.81 | 2.81 |
316.98 | 3.77 | 3.77 |
478.55 | 2.57 | 2.57 |
440.91 | 4.29 | 4.29 |
400.28 | 3.81 | 3.81 |
382.49 | 4.43 | 4.43 |
420.44 | 5.18 | 5.18 |
374.36 | 3.83 | 3.83 |
232.20 | 1.11 | 1.11 |
397.62 | 3.75 | 3.75 |
437.48 | 4.48 | 4.48 |
277.33 | 4.97 | 4.97 |
435.53 | 5.07 | 5.07 |
337.41 | 3.68 | 3.68 |
381.43 | 3.30 | 3.30 |
412.53 | 5.24 | 5.24 |
510.63 | 6.23 | 6.23 |
514.60 | 1.89 | 1.89 |
400.52 | 4.63 | 4.63 |
351.79 | 4.58 | 4.58 |
327.34 | 3.60 | 3.60 |
292.34 | 4.44 | 4.44 |
337.34 | 3.07 | 3.07 |
442.61 | 3.70 | 3.70 |
492.35 | 5.15 | 5.15 |
344.43 | 2.52 | 2.52 |
393.49 | 4.79 | 4.79 |
317.27 | 5.37 | 5.37 |
338.37 | 2.55 | 2.55 |
405.47 | 3.85 | 3.85 |
380.49 | 3.66 | 3.66 |
369.27 | 4.19 | 4.19 |
342.17 | 3.00 | 3.00 |
383.54 | 4.29 | 4.29 |
445.50 | 4.38 | 4.38 |
345.66 | 3.93 | 3.93 |
389.50 | 3.35 | 3.35 |
426.30 | 4.17 | 4.17 |
416.86 | 4.50 | 4.50 |
337.43 | 3.59 | 3.59 |
346.26 | 4.95 | 4.95 |
362.48 | 3.12 | 3.12 |
392.50 | 3.73 | 3.73 |
337.40 | 4.50 | 4.50 |
429.47 | 5.05 | 5.05 |
335.81 | 4.23 | 4.23 |
331.37 | 3.39 | 3.39 |
422.34 | 4.66 | 4.66 |
459.75 | 3.38 | 3.38 |
322.19 | 3.96 | 3.96 |
335.28 | 3.65 | 3.65 |
393.19 | 4.26 | 4.26 |
321.42 | 3.88 | 3.88 |
420.45 | 3.70 | 3.70 |
455.56 | 4.55 | 4.55 |
290.75 | 3.37 | 3.37 |
279.30 | 4.36 | 4.36 |
485.43 | 5.70 | 5.70 |
293.78 | 2.80 | 2.80 |
431.90 | 4.79 | 4.79 |
460.00 | 3.54 | 3.54 |
253.37 | 5.09 | 5.09 |
325.25 | 3.33 | 3.33 |
311.37 | 3.55 | 3.55 |
494.57 | 3.34 | 3.34 |
382.46 | 5.66 | 5.66 |
505.10 | 4.69 | 4.69 |
321.43 | 3.89 | 3.89 |
443.79 | 4.11 | 4.11 |
308.79 | 3.57 | 3.57 |
458.54 | 2.79 | 2.79 |
329.36 | 3.16 | 3.16 |
494.64 | 2.55 | 2.55 |
315.59 | 4.22 | 4.22 |
457.56 | 3.46 | 3.46 |
311.77 | 3.72 | 3.72 |
318.41 | 4.37 | 4.37 |
354.79 | 3.82 | 3.82 |
234.21 | 2.61 | 2.61 |
252.27 | 3.47 | 3.47 |
486.94 | 3.44 | 3.44 |
396.86 | 4.55 | 4.55 |
268.27 | 3.17 | 3.17 |
474.59 | 4.29 | 4.29 |
397.72 | 5.51 | 5.51 |
413.95 | 4.44 | 4.44 |
419.87 | 3.80 | 3.80 |
341.35 | 2.92 | 2.92 |
448.59 | 4.79 | 4.79 |
458.90 | 4.48 | 4.48 |
429.50 | 2.80 | 2.80 |
359.31 | 4.54 | 4.54 |
336.83 | 3.69 | 3.69 |
319.37 | 3.83 | 3.83 |
259.27 | 1.89 | 1.89 |
591.63 | 5.71 | 5.71 |
385.51 | 3.72 | 3.72 |
403.50 | 4.58 | 4.58 |
387.89 | 4.97 | 4.97 |
390.42 | 1.20 | 1.20 |
472.36 | 5.07 | 5.07 |
359.86 | 4.73 | 4.73 |
394.86 | 4.20 | 4.20 |
404.30 | 3.79 | 3.79 |
451.58 | 1.94 | 1.94 |
400.50 | 2.86 | 2.86 |
426.56 | 2.50 | 2.50 |
373.48 | 3.29 | 3.29 |
374.40 | 3.86 | 3.86 |
357.39 | 3.84 | 3.84 |
413.43 | 1.88 | 1.88 |
324.43 | 4.43 | 4.43 |
354.37 | 3.81 | 3.81 |
305.72 | 4.17 | 4.17 |
355.47 | 3.39 | 3.39 |
413.86 | 4.45 | 4.45 |
542.06 | 4.82 | 4.82 |
688.63 | 5.48 | 5.48 |
366.22 | 4.53 | 4.53 |
472.98 | 4.67 | 4.67 |
410.45 | 3.53 | 3.53 |
406.46 | 2.75 | 2.75 |
428.60 | 2.62 | 2.62 |
544.61 | 3.17 | 3.17 |
462.52 | 6.52 | 6.52 |
492.50 | 4.23 | 4.23 |
327.37 | 3.25 | 3.25 |
364.47 | 4.10 | 4.10 |
335.20 | 3.48 | 3.48 |
324.21 | 4.20 | 4.20 |
342.39 | 4.01 | 4.01 |
248.67 | 2.31 | 2.31 |
354.36 | 3.21 | 3.21 |
404.47 | 3.54 | 3.54 |
331.18 | 3.45 | 3.45 |
486.98 | 3.57 | 3.57 |
442.50 | 3.38 | 3.38 |
287.34 | 2.16 | 2.16 |
315.33 | 1.78 | 1.78 |
306.30 | 3.06 | 3.06 |
424.51 | 4.44 | 4.44 |
427.51 | 4.06 | 4.06 |
364.88 | 4.98 | 4.98 |
363.47 | 3.34 | 3.34 |
421.88 | 4.24 | 4.24 |
400.46 | 4.04 | 4.04 |
387.44 | 1.39 | 1.39 |
316.41 | 3.93 | 3.93 |
346.41 | 5.21 | 5.21 |
487.92 | 4.57 | 4.57 |
369.49 | 3.73 | 3.73 |
371.48 | 5.55 | 5.55 |
309.68 | 4.03 | 4.03 |
297.72 | 2.89 | 2.89 |
316.36 | -0.14 | -0.14 |
384.28 | 4.11 | 4.11 |
319.41 | 4.02 | 4.02 |
311.77 | 4.77 | 4.77 |
285.74 | 3.09 | 3.09 |
378.39 | 2.84 | 2.84 |
357.40 | 3.32 | 3.32 |
330.43 | 4.23 | 4.23 |
371.42 | 3.63 | 3.63 |
334.38 | 3.73 | 3.73 |
409.55 | 2.40 | 2.40 |
333.42 | 4.32 | 4.32 |
595.03 | ||
298.37 | 3.43 | 3.43 |
387.33 | 2.38 | 2.38 |
282.30 | 2.76 | 2.76 |
494.98 | 3.00 | 3.00 |
307.35 | 4.13 | 4.13 |
278.29 | 2.13 | 2.13 |
374.19 | 3.90 | 3.90 |
372.22 | 4.59 | 4.59 |
400.91 | 2.86 | 2.86 |
450.52 | 4.09 | 4.09 |
338.32 | 2.90 | 2.90 |
387.48 | 3.64 | 3.64 |
481.62 | 4.64 | 4.64 |
344.46 | 3.63 | 3.63 |
361.40 | 3.19 | 3.19 |
376.44 | 4.20 | 4.20 |
380.45 | 4.93 | 4.93 |
447.39 | 5.07 | 5.07 |
471.62 | 5.41 | 5.41 |
365.28 | 3.08 | 3.08 |
428.96 | 4.77 | 4.77 |
339.40 | 3.75 | 3.75 |
462.98 | 3.75 | 3.75 |
352.80 | 4.75 | 4.75 |
423.65 | 3.28 | 3.28 |
385.33 | 3.74 | 3.74 |
523.56 | 4.03 | 4.03 |
418.52 | 4.43 | 4.43 |
398.55 | 5.15 | 5.15 |
323.72 | 3.70 | 3.70 |
263.73 | 2.55 | 2.55 |
359.48 | 4.14 | 4.14 |
335.81 | 4.23 | 4.23 |
267.30 | 4.03 | 4.03 |
445.56 | 3.27 | 3.27 |
353.23 | 4.38 | 4.38 |
376.43 | 4.50 | 4.50 |
467.60 | 1.67 | 1.67 |
421.45 | 4.19 | 4.19 |
243.26 | 1.13 | 1.13 |
415.52 | 5.88 | 5.88 |
404.70 | 4.46 | 4.46 |
393.42 | 4.89 | 4.89 |
502.02 | 5.05 | 5.05 |
357.79 | 4.47 | 4.47 |
461.52 | 5.70 | 5.70 |
462.55 | 4.42 | 4.42 |
462.33 | 3.91 | 3.91 |
390.39 | 4.54 | 4.54 |
308.38 | 4.75 | 4.75 |
492.62 | 5.57 | 5.57 |
325.35 | 3.19 | 3.19 |
173.21 | 2.56 | 2.56 |
473.63 | 4.66 | 4.66 |
445.52 | 3.93 | 3.93 |
289.40 | 2.65 | 2.65 |
442.63 | 4.40 | 4.40 |
387.39 | 5.03 | 5.03 |
376.41 | 5.15 | 5.15 |
475.53 | 4.21 | 4.21 |
471.56 | 2.84 | 2.84 |
338.48 | 4.08 | 4.08 |
431.32 | 3.79 | 3.79 |
401.47 | 4.70 | 4.70 |
466.42 | 5.82 | 5.82 |
335.27 | 4.87 | 4.87 |
483.46 | 3.91 | 3.91 |
340.40 | 4.61 | 4.61 |
309.37 | 3.30 | 3.30 |
355.26 | 2.94 | 2.94 |
297.36 | 2.86 | 2.86 |
433.56 | 2.64 | 2.64 |
542.08 | 5.19 | 5.19 |
333.39 | 4.46 | 4.46 |
322.39 | 3.91 | 3.91 |
374.40 | 3.47 | 3.47 |
445.36 | 3.12 | 3.12 |
361.47 | 2.30 | 2.30 |
372.43 | 3.70 | 3.70 |
418.49 | 2.06 | 2.06 |
419.87 | 3.80 | 3.80 |
276.72 | 2.92 | 2.92 |
407.47 | 2.60 | 2.60 |
459.46 | 4.19 | 4.19 |
377.40 | 4.71 | 4.71 |
394.46 | 3.84 | 3.84 |
387.48 | 3.95 | 3.95 |
349.46 | 2.72 | 2.72 |
401.49 | 3.71 | 3.71 |
426.50 | 4.86 | 4.86 |
493.99 | 3.50 | 3.50 |
366.45 | 5.02 | 5.02 |
560.68 | 3.07 | 3.07 |
431.53 | 2.12 | 2.12 |
456.59 | 3.84 | 3.84 |
459.98 | 3.78 | 3.78 |
334.22 | 4.39 | 4.39 |
235.25 | 2.24 | 2.24 |
458.77 | 3.92 | 3.92 |
323.36 | 3.79 | 3.79 |
355.42 | 3.78 | 3.78 |
481.62 | 2.55 | 2.55 |
263.73 | 2.55 | 2.55 |
535.53 | 4.95 | 4.95 |
426.49 | 3.53 | 3.53 |
372.38 | 3.44 | 3.44 |
401.46 | 3.83 | 3.83 |
391.45 | 3.88 | 3.88 |
407.29 | 4.51 | 4.51 |
434.59 | 3.24 | 3.24 |
303.81 | 4.11 | 4.11 |
330.84 | 2.43 | 2.43 |
337.40 | 0.52 | 0.52 |
531.66 | 4.13 | 4.13 |
400.89 | 4.70 | 4.70 |
416.48 | 2.86 | 2.86 |
388.45 | 2.57 | 2.57 |
439.52 | 4.24 | 4.24 |
340.81 | 4.51 | 4.51 |
386.25 | 4.89 | 4.89 |
294.31 | 3.02 | 3.02 |
470.60 | 4.46 | 4.46 |
350.45 | 5.32 | 5.32 |
490.54 | 3.74 | 3.74 |
463.32 | 3.90 | 3.90 |
307.35 | 4.05 | 4.05 |
479.60 | 3.44 | 3.44 |
369.57 | 6.07 | 6.07 |
340.42 | 5.48 | 5.48 |
334.60 | 4.79 | 4.79 |
406.47 | 3.94 | 3.94 |
462.37 | 3.01 | 3.01 |
544.61 | 3.17 | 3.17 |
344.46 | 3.63 | 3.63 |
301.80 | 4.80 | 4.80 |
412.50 | 4.24 | 4.24 |
332.45 | 4.02 | 4.02 |
454.52 | 4.96 | 4.96 |
375.44 | 4.19 | 4.19 |
318.37 | 3.80 | 3.80 |
467.41 | 3.58 | 3.58 |
494.67 | 5.74 | 5.74 |
437.55 | 4.68 | 4.68 |
370.48 | 2.72 | 2.72 |
447.58 | 3.89 | 3.89 |
420.47 | 5.35 | 5.35 |
282.30 | 3.86 | 3.86 |
264.26 | 1.82 | 1.82 |
549.74 | 4.42 | 4.42 |
350.29 | 3.64 | 3.64 |
438.44 | 4.04 | 4.04 |
275.78 | 3.77 | 3.77 |
253.33 | 3.31 | 3.31 |
494.04 | 4.12 | 4.12 |
445.47 | 4.02 | 4.02 |
333.43 | 4.04 | 4.04 |
277.37 | 4.16 | 4.16 |
336.35 | 1.92 | 1.92 |
249.71 | 2.24 | 2.24 |
352.42 | 3.46 | 3.46 |
436.94 | 4.53 | 4.53 |
367.45 | 3.26 | 3.26 |
480.01 | 3.81 | 3.81 |
339.37 | 2.55 | 2.55 |
385.45 | 2.76 | 2.76 |
322.32 | 2.50 | 2.50 |
390.51 | 4.39 | 4.39 |
400.53 | 4.26 | 4.26 |
456.57 | 2.73 | 2.73 |
431.49 | 3.31 | 3.31 |
318.36 | 3.81 | 3.81 |
372.42 | 5.04 | 5.04 |
392.96 | 3.27 | 3.27 |
433.49 | 4.30 | 4.30 |
497.57 | 2.92 | 2.92 |
442.59 | 2.43 | 2.43 |
426.49 | 4.03 | 4.03 |
372.38 | 3.87 | 3.87 |
399.40 | 3.95 | 3.95 |
356.45 | 3.58 | 3.58 |
282.30 | 1.89 | 1.89 |
402.36 | 3.81 | 3.81 |
279.30 | 4.36 | 4.36 |
355.35 | 3.31 | 3.31 |
406.44 | 5.04 | 5.04 |
309.44 | 4.15 | 4.15 |
394.86 | 4.13 | 4.13 |
302.36 | 3.93 | 3.93 |
401.37 | 2.91 | 2.91 |
366.17 | 1.93 | 1.93 |
371.42 | 3.78 | 3.78 |
421.46 | 4.81 | 4.81 |
386.83 | 4.66 | 4.66 |
416.39 | 3.92 | 3.92 |
358.83 | 5.64 | 5.64 |
335.81 | 3.24 | 3.24 |
351.59 | 3.72 | 3.72 |
438.87 | 4.62 | 4.62 |
322.36 | 3.18 | 3.18 |
367.39 | 3.02 | 3.02 |
365.46 | 3.01 | 3.01 |
444.56 | 5.49 | 5.49 |
279.34 | 3.72 | 3.72 |
375.80 | 3.09 | 3.09 |
401.56 | 4.22 | 4.22 |
294.74 | 3.94 | 3.94 |
343.60 | 3.66 | 3.66 |
313.79 | 4.09 | 4.09 |
330.32 | 3.27 | 3.27 |
271.35 | 3.31 | 3.31 |
359.39 | 3.85 | 3.85 |
324.38 | 3.92 | 3.92 |
419.53 | 4.74 | 4.74 |
436.49 | 2.76 | 2.76 |
321.72 | 1.82 | 1.82 |
456.54 | 5.21 | 5.21 |
429.43 | 3.69 | 3.69 |
308.29 | 3.71 | 3.71 |
414.51 | 4.67 | 4.67 |
480.61 | 2.27 | 2.27 |
386.50 | 4.90 | 4.90 |
465.95 | 1.86 | 1.86 |
458.31 | 4.56 | 4.56 |
406.44 | 3.98 | 3.98 |
352.44 | 2.25 | 2.25 |
368.39 | 4.12 | 4.12 |
515.54 | 4.64 | 4.64 |
406.45 | 1.50 | 1.50 |
415.40 | 3.30 | 3.30 |
331.39 | 3.59 | 3.59 |
481.60 | 3.69 | 3.69 |
307.76 | 3.02 | 3.02 |
375.45 | 4.45 | 4.45 |
432.55 | 4.38 | 4.38 |
373.41 | 2.73 | 2.73 |
499.98 | 4.04 | 4.04 |
507.87 | 5.74 | 5.74 |
309.37 | 4.25 | 4.25 |
425.77 | 5.63 | 5.63 |
266.77 | 1.88 | 1.88 |
380.92 | 3.20 | 3.20 |
471.99 | 5.34 | 5.34 |
470.04 | 5.32 | 5.32 |
447.54 | 3.35 | 3.35 |
310.38 | 3.60 | 3.60 |
468.62 | 3.70 | 3.70 |
311.77 | 3.72 | 3.72 |
531.66 | 4.13 | 4.13 |
534.16 | 5.27 | 5.27 |
307.35 | 4.22 | 4.22 |
517.63 | 3.82 | 3.82 |
411.32 | 3.73 | 3.73 |
381.28 | 5.32 | 5.32 |
341.79 | 4.78 | 4.78 |
401.36 | 3.45 | 3.45 |
329.79 | 2.91 | 2.91 |
361.40 | 4.27 | 4.27 |
814.84 | 5.62 | 5.62 |
409.51 | 4.39 | 4.39 |
274.32 | 2.24 | 2.24 |
312.28 | 2.09 | 2.09 |
420.30 | 4.09 | 4.09 |
277.76 | 3.00 | 3.00 |
357.23 | 2.33 | 2.33 |
496.05 | 6.28 | 6.28 |
481.57 | 3.58 | 3.58 |
489.60 | 5.04 | 5.04 |
367.45 | 4.08 | 4.08 |
304.15 | 3.60 | 3.60 |
342.40 | 3.61 | 3.61 |
393.47 | 4.31 | 4.31 |
486.64 | 2.55 | 2.55 |
381.21 | 5.13 | 5.13 |
390.92 | 4.60 | 4.60 |
421.52 | 3.71 | 3.71 |
354.84 | 3.31 | 3.31 |
457.53 | 3.98 | 3.98 |
452.58 | 4.14 | 4.14 |
459.73 | 5.34 | 5.34 |
301.37 | 3.32 | 3.32 |
431.92 | 4.55 | 4.55 |
294.76 | 3.26 | 3.26 |
374.42 | 3.47 | 3.47 |
380.45 | 3.72 | 3.72 |
256.91 | 3.57 | 3.57 |
468.55 | 5.20 | 5.20 |
421.55 | 4.82 | 4.82 |
376.89 | 5.15 | 5.15 |
376.44 | 4.76 | 4.76 |
418.49 | 4.87 | 4.87 |
266.17 | -0.08 | -0.08 |
264.67 | 1.99 | 1.99 |
265.19 | 0.64 | 0.64 |
373.66 | 4.02 | 4.02 |
375.26 | 4.28 | 4.28 |
528.53 | 2.75 | 2.75 |
289.22 | 3.02 | 3.02 |
362.39 | 4.66 | 4.66 |
406.47 | 3.81 | 3.81 |
265.27 | 3.15 | 3.15 |
299.24 | 2.70 | 2.70 |
441.47 | 3.64 | 3.64 |
338.34 | 2.38 | 2.38 |
342.40 | 4.08 | 4.08 |
292.68 | 2.79 | 2.79 |
358.79 | 2.77 | 2.77 |
389.07 | 3.43 | 3.43 |
409.15 | 3.51 | 3.51 |
291.31 | 2.70 | 2.70 |
453.93 | 3.54 | 3.54 |
325.37 | 2.57 | 2.57 |
259.70 | 2.50 | 2.50 |
436.49 | 4.05 | 4.05 |
351.37 | 2.82 | 2.82 |
351.37 | 2.94 | 2.94 |
374.42 | 3.41 | 3.41 |
415.42 | 4.09 | 4.09 |
334.17 | 2.70 | 2.70 |
369.36 | 2.96 | 2.96 |
340.36 | 3.28 | 3.28 |
333.32 | 1.95 | 1.95 |
358.15 | 1.69 | 1.69 |
534.00 | 3.56 | 3.56 |
477.45 | 3.77 | 3.77 |
408.85 | 2.78 | 2.78 |
343.22 | 4.27 | 4.27 |
257.27 | 2.37 | 2.37 |
385.49 | 4.17 | 4.17 |
381.34 | 3.33 | 3.33 |