Basic Information
ID: ALA1614089
Type: Functional
Description: PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y1: cell-based high-throughput dose response assay for inhibitors of cyclic nucleotide gated ion channel (CNGC) activity. In this assay, the parental HEK293 cell line transfected with a cyclic-nucleotide gated ion channel (CNGC)-based cAMP sensor is used to measure inhibition of isoproterenol-induced CNGC activity by test compound (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1546 (Screening assay (NPY-Y1 potentiators or agonists).)]
Organism: Homo sapiens
Cell type: HEK293
Activity Charts
Bioactivity
Activity Types for Assay ALA1614089
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 281.36 | 3.79 | 3.79 |
| 443.53 | 5.18 | 5.18 |
| 328.37 | 3.63 | 3.63 |
| 414.55 | 2.10 | 2.10 |
| 394.52 | 3.53 | 3.53 |
| 496.98 | 6.38 | 6.38 |
| 368.48 | 3.89 | 3.89 |
| 369.98 | 4.18 | 4.18 |
| 520.54 | 4.01 | 4.01 |
| 414.48 | 5.11 | 5.11 |
| 439.51 | 4.59 | 4.59 |
| 349.39 | 3.26 | 3.26 |
| 442.52 | 3.68 | 3.68 |
| 373.37 | 5.01 | 5.01 |
| 319.77 | 3.60 | 3.60 |
| 317.82 | 2.84 | 2.84 |
| 375.80 | 3.09 | 3.09 |
| 316.36 | 4.16 | 4.16 |
| 446.33 | 4.11 | 4.11 |
| 352.80 | 2.45 | 2.45 |
| 294.36 | 3.29 | 3.29 |
| 391.47 | 2.82 | 2.82 |
| 375.48 | 3.59 | 3.59 |
| 435.71 | 6.05 | 6.05 |