Basic Information
ID: ALA1614202
Type: Functional
Description: PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of Cruzain. (Class of assay: confirmatory) [Related pubchem assays: 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (cruzain qHTS without detergent), 1478 (cruzain qHTS with detergent)]
Organism: Trypanosoma cruzi
Activity Charts
Bioactivity
Activity Types for Assay ALA1614202
Potency
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 253.27 | 0.83 | 0.83 |
| 506.60 | 7.01 | 7.01 |
| 351.86 | 2.69 | 2.69 |
| 331.80 | 3.33 | 3.33 |
| 182.22 | 3.21 | 3.21 |
| 428.34 | 6.85 | 6.85 |
| 204.62 | 2.16 | 2.16 |
| 512.75 | 5.63 | 5.63 |
| 367.92 | 5.32 | 5.32 |
| 359.23 | 3.60 | 3.60 |
| 300.27 | 2.40 | 2.40 |
| 340.34 | 3.32 | 3.32 |
| 288.31 | 2.80 | 2.80 |
| 298.33 | 2.98 | 2.98 |
| 294.36 | 3.15 | 3.15 |
| 233.28 | 1.13 | 1.13 |
| 254.30 | 2.31 | 2.31 |
| 254.30 | 2.31 | 2.31 |
| 266.31 | 2.31 | 2.31 |
| 359.23 | 3.60 | 3.60 |
| 356.43 | 4.51 | 4.51 |
| 348.33 | 3.86 | 3.86 |
| 268.32 | 2.55 | 2.55 |
| 268.32 | 2.70 | 2.70 |
| 316.32 | 3.12 | 3.12 |
| 349.23 | 4.15 | 4.15 |
| 284.32 | 1.67 | 1.67 |
| 312.23 | 2.44 | 2.44 |
| 300.27 | 2.74 | 2.74 |
| 336.25 | 2.98 | 2.98 |
| 340.34 | 3.83 | 3.83 |
| 298.74 | 3.11 | 3.11 |
| 226.24 | 1.53 | 1.53 |
| 294.36 | 3.23 | 3.23 |
| 256.27 | 0.89 | 0.89 |
| 325.33 | 2.75 | 2.75 |
| 298.33 | 2.98 | 2.98 |
| 314.78 | 3.49 | 3.49 |
| 338.80 | 4.21 | 4.21 |
| 336.25 | 2.64 | 2.64 |
| 298.74 | 2.77 | 2.77 |
| 334.72 | 3.02 | 3.02 |
| 280.34 | 2.84 | 2.84 |
| 240.27 | 1.92 | 1.92 |
| 345.83 | 2.90 | 2.90 |
| 207.19 | -1.32 | -1.32 |
| 193.17 | -1.63 | -1.63 |
| 325.42 | 3.02 | 3.02 |
| 281.31 | 3.07 | 3.07 |
| 391.42 | 3.07 | 3.07 |
| 490.87 | 5.01 | 5.01 |
| 374.24 | 3.06 | 3.06 |
| 592.12 | 4.26 | 4.26 |
| 369.31 | 1.58 | 1.58 |
| 368.43 | 3.02 | 3.02 |
| 395.40 | 3.13 | 3.13 |
| 309.37 | 2.93 | 2.93 |
| 373.41 | 4.82 | 4.82 |
| 510.54 | 5.52 | 5.52 |
| 220.28 | 0.95 | 0.95 |
| 504.89 | 4.88 | 4.88 |
| 414.77 | 3.27 | 3.27 |
| 405.54 | 4.66 | 4.66 |
| 425.96 | 5.01 | 5.01 |
| 272.36 | 1.72 | 1.72 |
| 270.25 | -0.56 | -0.56 |
| 405.54 | 4.66 | 4.66 |
| 232.29 | 1.17 | 1.17 |
| 391.52 | 4.35 | 4.35 |
| 405.54 | 4.66 | 4.66 |
| 456.50 | 4.61 | 4.61 |
| 275.18 | 1.84 | 1.84 |
| 276.30 | -0.58 | -0.58 |
| 529.90 | 5.49 | 5.49 |
| 442.57 | 3.50 | 3.50 |
| 419.57 | 4.97 | 4.97 |
| 381.22 | 2.91 | 2.91 |
| 363.39 | 0.80 | 0.80 |
| 283.29 | 0.87 | 0.87 |
| 419.57 | 4.97 | 4.97 |
| 318.37 | 1.45 | 1.45 |
| 361.49 | 3.96 | 3.96 |
| 399.40 | 1.84 | 1.84 |
| 337.80 | 2.76 | 2.76 |
| 244.30 | 0.94 | 0.94 |
| 368.42 | 0.44 | 0.44 |
| 379.46 | 3.85 | 3.85 |
| 451.41 | 3.39 | 3.39 |
| 220.28 | 1.38 | 1.38 |
| 449.21 | 3.92 | 3.92 |
| 426.56 | 5.26 | 5.26 |
| 303.71 | 0.69 | 0.69 |
| 359.47 | 3.72 | 3.72 |
| 349.35 | 2.87 | 2.87 |
| 385.53 | 3.06 | 3.06 |
| 448.48 | 3.36 | 3.36 |
| 482.89 | 4.89 | 4.89 |
| 558.86 | 6.03 | 6.03 |
| 284.36 | 0.75 | 0.75 |
| 437.56 | 4.27 | 4.27 |
| 426.48 | 4.60 | 4.60 |
| 361.40 | 4.68 | 4.68 |
| 424.35 | 4.86 | 4.86 |
| 370.57 | 4.56 | 4.56 |
| 224.26 | 3.49 | 3.49 |
| 342.21 | 4.20 | 4.20 |
| 535.86 | 4.92 | 4.92 |
| 333.34 | 3.32 | 3.32 |
| 342.41 | 3.81 | 3.81 |
| 593.31 | 6.68 | 6.68 |
| 338.37 | 4.00 | 4.00 |
| 470.88 | 4.83 | 4.83 |
| 330.40 | 3.99 | 3.99 |
| 504.89 | 5.32 | 5.32 |
| 347.37 | 3.00 | 3.00 |
| 489.88 | 4.58 | 4.58 |
| 313.79 | 3.60 | 3.60 |
| 486.45 | 4.37 | 4.37 |
| 347.41 | 3.75 | 3.75 |
| 448.55 | 4.34 | 4.34 |
| 332.77 | 3.63 | 3.63 |
| 447.62 | 5.87 | 5.87 |
| 504.89 | 5.32 | 5.32 |
| 423.54 | 3.96 | 3.96 |
| 297.32 | 0.83 | 0.83 |
| 377.40 | 3.00 | 3.00 |
| 420.82 | 3.54 | 3.54 |
| 377.44 | 3.29 | 3.29 |
| 377.41 | 1.19 | 1.19 |
| 426.56 | 5.26 | 5.26 |
| 478.55 | 3.92 | 3.92 |
| 344.42 | 4.06 | 4.06 |
| 346.77 | 2.25 | 2.25 |
| 496.52 | 5.13 | 5.13 |
| 347.41 | 2.51 | 2.51 |
| 282.35 | 2.94 | 2.94 |
| 447.63 | 4.28 | 4.28 |
| 385.82 | 4.28 | 4.28 |
| 207.24 | 0.60 | 0.60 |
| 349.34 | 3.03 | 3.03 |
| 496.91 | 5.28 | 5.28 |
| 294.36 | 3.15 | 3.15 |
| 315.33 | 2.78 | 2.78 |
| 525.31 | 5.67 | 5.67 |
| 235.25 | -0.02 | -0.02 |
| 343.42 | 2.60 | 2.60 |
| 454.01 | 5.71 | 5.71 |
| 410.43 | 4.31 | 4.31 |
| 432.48 | 3.66 | 3.66 |
| 388.92 | 4.29 | 4.29 |
| 485.45 | 3.47 | 3.47 |
| 363.84 | 2.23 | 2.23 |
| 464.01 | 4.01 | 4.01 |
| 315.25 | 2.70 | 2.70 |
| 355.31 | 2.35 | 2.35 |
| 348.86 | 3.44 | 3.44 |
| 436.44 | 3.49 | 3.49 |
| 382.25 | 2.87 | 2.87 |
| 304.44 | 3.00 | 3.00 |
| 459.31 | 4.74 | 4.74 |
| 363.37 | 3.26 | 3.26 |
| 455.60 | 5.90 | 5.90 |
| 274.33 | 0.57 | 0.57 |
| 386.36 | 1.82 | 1.82 |
| 559.76 | 6.32 | 6.32 |
| 292.30 | -0.45 | -0.45 |
| 306.32 | 2.83 | 2.83 |
| 219.25 | 0.74 | 0.74 |
| 257.32 | 3.02 | 3.02 |
| 373.50 | 4.11 | 4.11 |
| 352.35 | -0.27 | -0.27 |
| 322.33 | 0.61 | 0.61 |
| 378.41 | 4.12 | 4.12 |
| 384.48 | 2.77 | 2.77 |
| 310.39 | 1.28 | 1.28 |
| 447.62 | 5.70 | 5.70 |
| 510.01 | 4.42 | 4.42 |
| 518.92 | 5.27 | 5.27 |
| 456.85 | 4.30 | 4.30 |
| 419.57 | 4.92 | 4.92 |
| 419.57 | 5.13 | 5.13 |
| 432.43 | 3.07 | 3.07 |
| 540.93 | 6.17 | 6.17 |
| 347.41 | 2.51 | 2.51 |
| 515.88 | 4.88 | 4.88 |
| 287.25 | 0.18 | 0.18 |
| 431.49 | 3.97 | 3.97 |
| 299.71 | 3.94 | 3.94 |
| 432.48 | 3.66 | 3.66 |
| 433.60 | 5.44 | 5.44 |
| 369.42 | 2.53 | 2.53 |
| 381.39 | 5.40 | 5.40 |
| 486.45 | 4.37 | 4.37 |
| 433.60 | 5.36 | 5.36 |
| 283.29 | 0.35 | 0.35 |
| 283.29 | 0.35 | 0.35 |
| 331.41 | 2.67 | 2.67 |
| 319.32 | 3.06 | 3.06 |
| 265.27 | 3.29 | 3.29 |
| 356.43 | 4.20 | 4.20 |
| 452.89 | 4.00 | 4.00 |
| 379.46 | 3.78 | 3.78 |
| 391.42 | 4.34 | 4.34 |
| 357.41 | -1.46 | -1.46 |
| 329.84 | 3.61 | 3.61 |
| 352.42 | 3.30 | 3.30 |
| 458.59 | 4.74 | 4.74 |
| 447.62 | 5.65 | 5.65 |
| 470.88 | 4.69 | 4.69 |
| 356.43 | 4.51 | 4.51 |
| 418.45 | 3.35 | 3.35 |
| 235.25 | 0.12 | 0.12 |
| 435.57 | 4.75 | 4.75 |
| 352.82 | 2.52 | 2.52 |
| 439.99 | 5.32 | 5.32 |
| 466.92 | 4.31 | 4.31 |
| 395.91 | 2.78 | 2.78 |
| 533.93 | 5.08 | 5.08 |
| 439.99 | 5.40 | 5.40 |
| 310.36 | 2.85 | 2.85 |
| 405.54 | 4.74 | 4.74 |
| 525.31 | 5.67 | 5.67 |
| 297.31 | 1.84 | 1.84 |
| 490.49 | 5.22 | 5.22 |
| 283.29 | 0.52 | 0.52 |
| 345.36 | 4.04 | 4.04 |
| 540.93 | 6.17 | 6.17 |
| 426.56 | 5.26 | 5.26 |
| 303.31 | 1.34 | 1.34 |
| 294.36 | 3.15 | 3.15 |
| 248.33 | 1.44 | 1.44 |
| 275.35 | 2.43 | 2.43 |
| 435.57 | 4.75 | 4.75 |
| 441.58 | 5.51 | 5.51 |
| 234.26 | -0.35 | -0.35 |
| 363.44 | 2.50 | 2.50 |
| 393.44 | 2.13 | 2.13 |
| 388.42 | 5.10 | 5.10 |
| 383.50 | 4.67 | 4.67 |
| 491.85 | 4.41 | 4.41 |
| 421.54 | 4.36 | 4.36 |
| 482.92 | 4.01 | 4.01 |
| 317.35 | 3.61 | 3.61 |
| 452.97 | 4.99 | 4.99 |
| 425.44 | 4.89 | 4.89 |
| 504.89 | 5.32 | 5.32 |
| 330.40 | 3.99 | 3.99 |
| 379.44 | 3.05 | 3.05 |
| 299.29 | 0.05 | 0.05 |
| 262.32 | 0.43 | 0.43 |
| 430.48 | 2.40 | 2.40 |
| 440.45 | 5.00 | 5.00 |
| 380.47 | 3.52 | 3.52 |
| 310.36 | 2.85 | 2.85 |
| 386.50 | 4.03 | 4.03 |
| 313.33 | 2.44 | 2.44 |
| 355.41 | 3.45 | 3.45 |
| 425.46 | 1.82 | 1.82 |
| 204.24 | 0.32 | 0.32 |
| 377.40 | 3.00 | 3.00 |
| 416.39 | 2.85 | 2.85 |
| 270.25 | -0.56 | -0.56 |
| 192.23 | -0.12 | -0.12 |
| 361.40 | 3.30 | 3.30 |
| 433.60 | 5.44 | 5.44 |
| 269.26 | 0.04 | 0.04 |
| 433.60 | 5.36 | 5.36 |
| 419.57 | 5.05 | 5.05 |
| 462.55 | 4.30 | 4.30 |
| 353.84 | 1.37 | 1.37 |
| 363.41 | 2.13 | 2.13 |
| 392.48 | 4.66 | 4.66 |
| 380.49 | 2.64 | 2.64 |
| 296.33 | 1.35 | 1.35 |
| 336.44 | 4.14 | 4.14 |
| 319.32 | 3.51 | 3.51 |
| 419.57 | 4.97 | 4.97 |
| 192.23 | 0.61 | 0.61 |
| 305.37 | 2.31 | 2.31 |
| 293.33 | 1.77 | 1.77 |
| 419.57 | 5.05 | 5.05 |
| 360.27 | 3.79 | 3.79 |
| 345.36 | 4.07 | 4.07 |
| 419.57 | 5.05 | 5.05 |
| 179.18 | -0.18 | -0.18 |
| 361.40 | 2.92 | 2.92 |
| 348.36 | 2.02 | 2.02 |
| 433.60 | 5.31 | 5.31 |
| 421.54 | 4.36 | 4.36 |
| 385.50 | 4.16 | 4.16 |
| 448.48 | 3.36 | 3.36 |
| 325.75 | 3.90 | 3.90 |
| 392.44 | 4.43 | 4.43 |
| 439.99 | 5.40 | 5.40 |
| 328.39 | 3.14 | 3.14 |
| 311.35 | 1.09 | 1.09 |
| 426.57 | 4.53 | 4.53 |
| 321.35 | 2.25 | 2.25 |
| 420.26 | 2.68 | 2.68 |
| 505.37 | 5.37 | 5.37 |
| 205.22 | 0.35 | 0.35 |
| 418.45 | 3.35 | 3.35 |
| 346.16 | 4.27 | 4.27 |
| 379.44 | 3.31 | 3.31 |
| 250.28 | 1.22 | 1.22 |
| 363.41 | 2.13 | 2.13 |
| 448.53 | 3.91 | 3.91 |
| 432.48 | 3.66 | 3.66 |
| 282.34 | 0.50 | 0.50 |
| 336.44 | 4.14 | 4.14 |
| 361.40 | 3.30 | 3.30 |
| 361.40 | 4.68 | 4.68 |
| 268.32 | 2.70 | 2.70 |
| 377.40 | 3.00 | 3.00 |
| 531.88 | 4.28 | 4.28 |
| 303.36 | 2.11 | 2.11 |
| 298.38 | 1.14 | 1.14 |
| 550.92 | 5.03 | 5.03 |
| 234.26 | 0.01 | 0.01 |
| 270.30 | 1.28 | 1.28 |
| 510.94 | 5.67 | 5.67 |
| 297.32 | 0.83 | 0.83 |
| 343.38 | 1.74 | 1.74 |
| 362.84 | 3.79 | 3.79 |
| 240.27 | 1.48 | 1.48 |
| 400.48 | 3.22 | 3.22 |
| 525.31 | 5.67 | 5.67 |
| 463.40 | 4.15 | 4.15 |
| 455.60 | 5.90 | 5.90 |
| 330.34 | 3.65 | 3.65 |
| 361.40 | 3.30 | 3.30 |
| 388.45 | 3.67 | 3.67 |
| 336.36 | 0.92 | 0.92 |
| 314.20 | 3.42 | 3.42 |
| 469.46 | 2.60 | 2.60 |
| 406.83 | 5.87 | 5.87 |
| 314.20 | 3.42 | 3.42 |
| 320.82 | 2.06 | 2.06 |
| 314.20 | 3.42 | 3.42 |
| 319.22 | 2.53 | 2.53 |
| 330.34 | 3.38 | 3.38 |
| 303.39 | 3.38 | 3.38 |
| 319.22 | 2.53 | 2.53 |
| 322.36 | 3.66 | 3.66 |
| 415.37 | 3.13 | 3.13 |