Basic Information
ID: ALA1614242
Type: Functional
Description: PUBCHEM_BIOASSAY: Mode of action assay-Automated electrophysiology assay of compounds that potentiate KCNQ2 potassium channel. (Class of assay: confirmatory) [Related pubchem assays: 2258 (Summary assay for the KCNQ2 potentiators.), 2558 (Automated patch clamp assay for KCNQ2 mutant W236L cell line with 936 test compounds, and 91 are found active.), 2239 (Primary HTS assay for KCNQ2 potentiators with 305606 compounds tested, and 1644 are found to be active.), 2287 (Confirmatory screen assay in duplicate for 1189 compounds identified through HTS, and 804 are found active.)]
Organism: Rattus norvegicus
Cell type: W236L
Activity Charts
Bioactivity
Activity Types for Assay ALA1614242
EC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 350.09 | 4.19 | 4.19 |
| 321.41 | 4.68 | 4.68 |
| 284.27 | 2.48 | 2.48 |
| 329.36 | 5.48 | 5.48 |
| 437.93 | 3.08 | 3.08 |
| 437.93 | 3.08 | 3.08 |
| 288.40 | 4.02 | 4.02 |
| 358.44 | 3.68 | 3.68 |
| 437.93 | 3.33 | 3.33 |
| 451.96 | 3.47 | 3.47 |
| 357.80 | 5.69 | 5.69 |
| 281.45 | 4.22 | 4.22 |
| 423.91 | 2.82 | 2.82 |
| 423.91 | 2.82 | 2.82 |
| 459.94 | 3.07 | 3.07 |
| 376.71 | 4.15 | 4.15 |
| 296.33 | 3.65 | 3.65 |
| 455.97 | 3.24 | 3.24 |
| 455.97 | 3.24 | 3.24 |
| 455.92 | 3.47 | 3.47 |
| 362.51 | 3.77 | 3.77 |
| 473.96 | 3.46 | 3.46 |
| 267.12 | 3.64 | 3.64 |
| 240.09 | 3.53 | 3.53 |
| 451.96 | 3.47 | 3.47 |
| 507.06 | 3.38 | 3.38 |
| 455.92 | 3.47 | 3.47 |
| 328.37 | 3.70 | 3.70 |
| 416.59 | 4.00 | 4.00 |
| 381.48 | 3.46 | 3.46 |
| 273.16 | 3.31 | 3.31 |
| 423.91 | 2.77 | 2.77 |
| 322.39 | 2.18 | 2.18 |
| 446.48 | 4.06 | 4.06 |
| 367.63 | 3.50 | 3.50 |
| 273.14 | 3.91 | 3.91 |