Basic Information
ID: ALA1614380
Type: Functional
Description: PUBCHEM_BIOASSAY: Late-stage luminescence-based cell-based dose response assay to identify inhibitors of NADPH oxidase 1 (NOX1): Purchased analogs. (Class of assay: confirmatory) [Related pubchem assays: 2752 (Primary screen (NOX1 inhibitors, synthesized analogs set 2)), 2532 (Dose response (NOX1 inhibitors, HEK/293 cells)), 2664 (Primary screen (NOX1 inhibitors, synthesized analogs)), 1792 (Primary Screen (NOX1 inhibitors)), 2556 (Counterscreen (Xanthine oxidase inhibitors)), 2538 (Dose response screen (NOX1 inhibitors)), 1796 (Summary AID (NOX1 inhibitors)), 2773 (Primary screen (NOX1 inhibitors, synthesized analogs set 3)), 2545 (Confirmation screen (NOX1 inhibitors, HEK/293 cells)), 2539 (Counterscreen (NOX2, NOX3, NOX4 inhibitors)), 2541 (Confirmation screen (NOX1 inhibitors)), 1823 (Counterscreen (luminal))]
Format: BAO_0000219
Organism: Homo sapiens
Target: NADPH oxidase 1(ALA1287628)
Document: ALA1201862
PubChem Source: AID:2808
Activity Charts
Bioactivity
Activity Types for Assay ALA1614380
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 407.51 | 4.95 | 4.95 |
| 318.87 | 4.89 | 4.89 |
| 403.98 | 3.94 | 3.94 |
| 341.37 | 5.32 | 5.32 |
| 437.53 | 4.31 | 4.31 |
| 286.33 | 5.00 | 5.00 |
| 296.37 | 5.41 | 5.41 |
| 199.28 | 3.89 | 3.89 |
| 229.30 | 3.90 | 3.90 |
| 334.03 | 5.66 | 5.66 |
| 295.37 | 4.45 | 4.45 |
| 326.40 | 5.42 | 5.42 |
| 314.36 | 5.55 | 5.55 |
| 330.82 | 6.06 | 6.06 |
| 422.27 | 6.02 | 6.02 |
| 339.44 | 5.48 | 5.48 |
| 312.37 | 5.12 | 5.12 |
| 310.40 | 5.72 | 5.72 |
| 326.40 | 5.42 | 5.42 |
| 234.30 | 4.05 | 4.05 |
| 330.82 | 6.06 | 6.06 |
| 341.37 | 5.32 | 5.32 |
| 312.37 | 5.12 | 5.12 |
| 310.40 | 5.72 | 5.72 |
| 341.37 | 5.32 | 5.32 |
| 241.31 | 4.10 | 4.10 |
| 372.42 | 5.13 | 5.13 |
| 320.89 | 4.24 | 4.24 |
| 388.89 | 5.26 | 5.26 |
| 311.13 | 3.74 | 3.74 |
| 287.23 | 2.92 | 2.92 |
| 266.13 | 3.83 | 3.83 |
| 474.69 | 3.93 | 3.93 |
| 439.92 | 5.07 | 5.07 |
| 196.25 | 3.13 | 3.13 |
| 212.66 | 3.25 | 3.25 |
| 338.79 | 5.78 | 5.78 |
| 229.30 | 3.90 | 3.90 |
| 268.32 | 3.04 | 3.04 |
| 356.79 | 3.75 | 3.75 |
| 243.33 | 3.95 | 3.95 |
| 356.43 | 5.43 | 5.43 |
| 340.38 | 5.25 | 5.25 |
| 318.78 | 4.78 | 4.78 |
| 333.75 | 4.68 | 4.68 |
| 342.40 | 5.12 | 5.12 |
| 283.27 | 3.93 | 3.93 |
| 416.48 | 5.45 | 5.45 |
| 416.65 | 4.10 | 4.10 |
| 301.42 | 4.12 | 4.12 |
| 348.36 | 4.57 | 4.57 |
| 306.75 | 4.91 | 4.91 |
| 389.50 | 5.76 | 5.76 |
| 318.78 | 4.78 | 4.78 |
| 286.36 | 4.46 | 4.46 |
| 233.72 | 4.55 | 4.55 |
| 318.78 | 4.78 | 4.78 |
| 281.14 | 3.75 | 3.75 |
| 333.75 | 4.68 | 4.68 |
| 387.91 | 5.69 | 5.69 |
| 379.37 | 5.04 | 5.04 |
| 344.59 | 4.19 | 4.19 |
| 401.51 | 5.90 | 5.90 |
| 423.49 | 4.09 | 4.09 |
| 298.35 | 4.20 | 4.20 |
| 299.31 | 4.03 | 4.03 |
| 285.35 | 3.41 | 3.41 |
| 312.27 | 4.82 | 4.82 |
| 453.50 | 5.87 | 5.87 |
| 380.25 | 5.39 | 5.39 |
| 263.75 | 4.56 | 4.56 |
| 356.79 | 4.82 | 4.82 |
| 304.30 | 3.32 | 3.32 |
| 338.81 | 5.93 | 5.93 |
| 306.75 | 4.91 | 4.91 |
| 339.18 | 3.85 | 3.85 |
| 297.36 | 5.68 | 5.68 |
| 374.61 | 4.03 | 4.03 |
| 323.20 | 5.43 | 5.43 |
| 325.37 | 3.25 | 3.25 |
| 296.36 | 2.33 | 2.33 |
| 353.23 | 5.44 | 5.44 |
| 320.42 | 3.01 | 3.01 |
| 333.75 | 4.68 | 4.68 |
| 267.12 | 3.23 | 3.23 |
| 434.66 | 4.21 | 4.21 |
| 335.02 | 5.14 | 5.14 |
| 350.13 | 4.73 | 4.73 |
| 284.22 | 2.62 | 2.62 |
| 369.34 | 5.95 | 5.95 |
| 217.27 | 4.03 | 4.03 |
| 353.43 | 5.37 | 5.37 |
| 386.45 | 5.44 | 5.44 |
| 363.78 | 4.69 | 4.69 |
| 372.42 | 5.13 | 5.13 |
| 443.72 | 4.16 | 4.16 |
| 345.81 | 4.73 | 4.73 |
| 363.37 | 4.82 | 4.82 |
| 356.64 | 5.05 | 5.05 |
| 356.21 | 3.86 | 3.86 |