Basic Information
ID: ALA1614388
Type: Binding
Description: PUBCHEM_BIOASSAY: TR-FRET counterscreen for FAK inhibitors: dose-response biochemical high throughput screening assay to identify inhibitors of Proline-rich tyrosine kinase 2 (Pyk2). (Class of assay: confirmatory) [Related pubchem assays: 794, 727, 810 ]
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA1614388
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 208.22 | 2.73 | 2.73 |
| 223.23 | 2.31 | 2.31 |
| 191.28 | 1.02 | 1.02 |
| 190.29 | 1.61 | 1.61 |
| 333.39 | 4.18 | 4.18 |
| 309.37 | 2.51 | 2.51 |
| 211.22 | 1.90 | 1.90 |
| 318.37 | 3.58 | 3.58 |
| 209.25 | 2.66 | 2.66 |
| 217.28 | 1.59 | 1.59 |
| 422.44 | 5.33 | 5.33 |
| 222.27 | 2.23 | 2.23 |
| 444.54 | 5.86 | 5.86 |
| 269.14 | 4.75 | 4.75 |
| 446.96 | 4.14 | 4.14 |
| 379.35 | 2.11 | 2.11 |
| 329.74 | 2.98 | 2.98 |
| 336.38 | 3.72 | 3.72 |
| 319.36 | 2.70 | 2.70 |
| 301.42 | 2.91 | 2.91 |
| 317.37 | 2.20 | 2.20 |
| 409.45 | 3.54 | 3.54 |
| 315.44 | 3.47 | 3.47 |
| 386.24 | 5.48 | 5.48 |
| 420.49 | 5.65 | 5.65 |
| 488.52 | 4.37 | 4.37 |
| 323.35 | 3.12 | 3.12 |
| 302.29 | 3.56 | 3.56 |
| 420.49 | 4.80 | 4.80 |
| 388.42 | 4.78 | 4.78 |
| 299.36 | 2.73 | 2.73 |
| 436.90 | 4.15 | 4.15 |
| 359.48 | 3.64 | 3.64 |
| 265.31 | 2.45 | 2.45 |
| 279.30 | 1.59 | 1.59 |
| 267.24 | 3.33 | 3.33 |
| 417.42 | 5.26 | 5.26 |
| 376.80 | 4.76 | 4.76 |
| 262.26 | 4.21 | 4.21 |
| 399.49 | 4.17 | 4.17 |
| 331.35 | 0.98 | 0.98 |
| 316.45 | 4.17 | 4.17 |
| 374.51 | 5.91 | 5.91 |
| 410.50 | 2.86 | 2.86 |
| 306.12 | 3.52 | 3.52 |
| 255.10 | 2.76 | 2.76 |
| 213.24 | 1.31 | 1.31 |
| 398.38 | 3.89 | 3.89 |
| 539.71 | 4.12 | 4.12 |
| 354.39 | 4.11 | 4.11 |
| 469.95 | 4.31 | 4.31 |
| 294.35 | 2.59 | 2.59 |
| 319.32 | 3.67 | 3.67 |
| 361.36 | 4.50 | 4.50 |
| 416.43 | 3.98 | 3.98 |
| 467.95 | 4.53 | 4.53 |
| 470.56 | 5.38 | 5.38 |
| 381.39 | 4.36 | 4.36 |
| 427.92 | 4.45 | 4.45 |
| 380.41 | 4.35 | 4.35 |
| 237.26 | 3.62 | 3.62 |
| 352.43 | 3.88 | 3.88 |
| 372.28 | 5.61 | 5.61 |
| 348.41 | 5.15 | 5.15 |
| 277.33 | 2.74 | 2.74 |
| 330.37 | 4.39 | 4.39 |
| 350.33 | 3.26 | 3.26 |
| 390.46 | 4.79 | 4.79 |
| 408.53 | 5.47 | 5.47 |
| 463.88 | 2.81 | 2.81 |
| 440.25 | 5.08 | 5.08 |
| 288.37 | 3.69 | 3.69 |
| 207.30 | 1.58 | 1.58 |
| 393.47 | 4.01 | 4.01 |
| 355.44 | 4.48 | 4.48 |
| 295.73 | 3.46 | 3.46 |
| 410.43 | 2.46 | 2.46 |
| 236.27 | 3.68 | 3.68 |
| 290.39 | 3.41 | 3.41 |
| 408.21 | 4.39 | 4.39 |
| 241.22 | 3.45 | 3.45 |
| 253.30 | 3.05 | 3.05 |
| 430.50 | 5.27 | 5.27 |
| 361.40 | 2.99 | 2.99 |
| 416.30 | 1.92 | 1.92 |
| 356.47 | 5.06 | 5.06 |
| 311.75 | 2.84 | 2.84 |
| 429.43 | 4.59 | 4.59 |
| 376.46 | 4.25 | 4.25 |
| 295.29 | 2.32 | 2.32 |
| 450.57 | 4.71 | 4.71 |
| 273.29 | 3.40 | 3.40 |
| 360.37 | 3.95 | 3.95 |
| 337.42 | 2.65 | 2.65 |
| 355.44 | 5.53 | 5.53 |
| 212.72 | 2.18 | 2.18 |
| 226.28 | 3.39 | 3.39 |
| 372.49 | 3.01 | 3.01 |
| 342.38 | 2.50 | 2.50 |
| 301.39 | 4.42 | 4.42 |
| 405.87 | 6.01 | 6.01 |
| 373.41 | 4.52 | 4.52 |
| 346.46 | 5.28 | 5.28 |
| 332.43 | 4.97 | 4.97 |
| 375.50 | 4.18 | 4.18 |
| 442.97 | 3.84 | 3.84 |
| 251.29 | 2.41 | 2.41 |
| 411.91 | 4.18 | 4.18 |
| 273.29 | 3.86 | 3.86 |
| 276.36 | 3.02 | 3.02 |
| 352.14 | 3.23 | 3.23 |
| 407.45 | 2.77 | 2.77 |
| 364.54 | 3.36 | 3.36 |
| 421.42 | 3.79 | 3.79 |
| 316.31 | 3.87 | 3.87 |
| 417.58 | 4.09 | 4.09 |
| 288.37 | 3.16 | 3.16 |
| 380.23 | 4.44 | 4.44 |
| 399.43 | 2.92 | 2.92 |
| 368.48 | 5.55 | 5.55 |
| 289.43 | 0.77 | 0.77 |
| 230.31 | 2.54 | 2.54 |
| 346.34 | 2.56 | 2.56 |
| 316.34 | 4.08 | 4.08 |
| 572.83 | 5.60 | 5.60 |
| 355.35 | 4.89 | 4.89 |
| 350.42 | 2.75 | 2.75 |
| 436.55 | 3.53 | 3.53 |
| 292.09 | 3.21 | 3.21 |
| 307.31 | 1.91 | 1.91 |
| 337.41 | 2.70 | 2.70 |
| 423.43 | 5.60 | 5.60 |
| 338.16 | 2.22 | 2.22 |
| 312.64 | 2.36 | 2.36 |
| 391.47 | 4.30 | 4.30 |
| 268.26 | 4.31 | 4.31 |
| 292.23 | 2.02 | 2.02 |
| 352.42 | 3.53 | 3.53 |
| 330.39 | 3.27 | 3.27 |
| 484.51 | 4.16 | 4.16 |
| 307.37 | 2.65 | 2.65 |
| 363.45 | 2.81 | 2.81 |
| 348.36 | 2.86 | 2.86 |
| 393.47 | 3.64 | 3.64 |
| 312.64 | 2.36 | 2.36 |
| 438.56 | 2.72 | 2.72 |
| 234.19 | 2.99 | 2.99 |
| 314.18 | 2.66 | 2.66 |
| 421.52 | 3.97 | 3.97 |
| 223.23 | 3.31 | 3.31 |
| 276.30 | 2.30 | 2.30 |
| 440.31 | 6.66 | 6.66 |
| 373.50 | 5.51 | 5.51 |
| 485.54 | 3.62 | 3.62 |
| 377.44 | 3.65 | 3.65 |
| 321.33 | 3.08 | 3.08 |
| 298.28 | 2.44 | 2.44 |
| 363.51 | 4.94 | 4.94 |
| 386.47 | 3.61 | 3.61 |
| 464.48 | 4.69 | 4.69 |
| 358.85 | 5.46 | 5.46 |
| 310.27 | 3.55 | 3.55 |
| 405.46 | 3.37 | 3.37 |
| 346.43 | 4.03 | 4.03 |
| 216.29 | 2.15 | 2.15 |
| 264.22 | 2.07 | 2.07 |
| 327.45 | 3.63 | 3.63 |
| 395.21 | 4.87 | 4.87 |
| 324.42 | 3.92 | 3.92 |
| 278.31 | 3.62 | 3.62 |
| 397.50 | 5.03 | 5.03 |
| 327.38 | 5.66 | 5.66 |
| 276.06 | 1.93 | 1.93 |
| 319.36 | 2.33 | 2.33 |
| 381.55 | 4.27 | 4.27 |
| 212.26 | 2.21 | 2.21 |
| 402.45 | 4.63 | 4.63 |
| 324.31 | 4.66 | 4.66 |
| 342.42 | 3.78 | 3.78 |
| 212.26 | 2.31 | 2.31 |
| 359.36 | 4.40 | 4.40 |
| 359.36 | 4.40 | 4.40 |
| 447.88 | 4.87 | 4.87 |
| 492.33 | 4.98 | 4.98 |
| 385.51 | 5.18 | 5.18 |
| 334.76 | 3.82 | 3.82 |
| 383.84 | 5.27 | 5.27 |
| 415.52 | 4.95 | 4.95 |
| 548.58 | 4.60 | 4.60 |
| 267.28 | 3.07 | 3.07 |
| 397.43 | 5.23 | 5.23 |
| 253.26 | 2.68 | 2.68 |
| 442.95 | 5.08 | 5.08 |
| 272.10 | 1.27 | 1.27 |
| 408.50 | 4.43 | 4.43 |
| 296.33 | 3.64 | 3.64 |
| 268.32 | 1.94 | 1.94 |
| 497.56 | 4.59 | 4.59 |
| 280.29 | 2.25 | 2.25 |
| 323.40 | 3.64 | 3.64 |
| 266.30 | 3.63 | 3.63 |
| 410.47 | 5.26 | 5.26 |
| 294.31 | 3.40 | 3.40 |
| 301.33 | 3.09 | 3.09 |
| 326.35 | 3.65 | 3.65 |
| 429.56 | 5.20 | 5.20 |
| 357.84 | 4.29 | 4.29 |
| 332.40 | 4.13 | 4.13 |
| 264.27 | 2.20 | 2.20 |
| 443.59 | 5.59 | 5.59 |