Basic Information
ID: ALA1614395
Type: Functional
Description: PUBCHEM_BIOASSAY: uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1777, AID1785, AID1786, AID1966, AID2136, AID2285, AID2495, AID434981, AID463105, AID488826, AID488935]
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA1614395
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 305.50 | 3.20 | 3.20 |
| 339.44 | 2.51 | 2.51 |
| 287.10 | 2.77 | 2.77 |
| 224.60 | 2.50 | 2.50 |
| 270.25 | 1.75 | 1.75 |
| 343.36 | 3.25 | 3.25 |
| 329.34 | 2.94 | 2.94 |
| 282.32 | 3.02 | 3.02 |
| 234.33 | 1.46 | 1.46 |
| 268.35 | 3.65 | 3.65 |
| 295.35 | 3.04 | 3.04 |
| 340.43 | 4.57 | 4.57 |
| 287.41 | 3.62 | 3.62 |
| 363.84 | 1.30 | 1.30 |
| 214.05 | 3.25 | 3.25 |
| 377.87 | 1.53 | 1.53 |
| 387.18 | 2.41 | 2.41 |
| 394.46 | 1.97 | 1.97 |
| 339.35 | 4.19 | 4.19 |
| 383.36 | 2.78 | 2.78 |
| 428.52 | 1.82 | 1.82 |
| 400.78 | 3.33 | 3.33 |
| 321.81 | 4.17 | 4.17 |
| 362.39 | 2.24 | 2.24 |
| 415.90 | 3.92 | 3.92 |
| 273.29 | 3.08 | 3.08 |
| 414.45 | 4.51 | 4.51 |
| 512.20 | 4.89 | 4.89 |
| 293.33 | 4.67 | 4.67 |
| 561.52 | 4.79 | 4.79 |
| 249.27 | 4.36 | 4.36 |
| 306.67 | 3.23 | 3.23 |
| 417.51 | 2.82 | 2.82 |
| 317.44 | 3.45 | 3.45 |
| 358.18 | 4.50 | 4.50 |
| 425.60 | 4.94 | 4.94 |
| 470.05 | 5.85 | 5.85 |
| 313.29 | 3.14 | 3.14 |
| 324.17 | 2.14 | 2.14 |
| 726.19 | 3.26 | 3.26 |
| 290.37 | 3.10 | 3.10 |
| 399.30 | 3.93 | 3.93 |
| 279.78 | 3.86 | 3.86 |
| 279.30 | 4.36 | 4.36 |
| 448.57 | 3.01 | 3.01 |
| 319.41 | 1.66 | 1.66 |
| 396.36 | 5.35 | 5.35 |
| 378.52 | 4.40 | 4.40 |
| 329.23 | 4.92 | 4.92 |
| 466.65 | 2.09 | 2.09 |
| 288.40 | 3.87 | 3.87 |
| 293.32 | 3.83 | 3.83 |
| 398.44 | 4.08 | 4.08 |
| 410.58 | 5.08 | 5.08 |
| 392.54 | 4.71 | 4.71 |
| 415.30 | 3.63 | 3.63 |
| 440.61 | 3.71 | 3.71 |
| 305.38 | 2.83 | 2.83 |
| 390.40 | 2.02 | 2.02 |
| 265.38 | 4.84 | 4.84 |
| 362.52 | 4.62 | 4.62 |
| 406.42 | 2.77 | 2.77 |
| 348.49 | 4.31 | 4.31 |
| 305.36 | 4.13 | 4.13 |
| 340.43 | 3.99 | 3.99 |
| 391.43 | 2.51 | 2.51 |
| 249.27 | 4.36 | 4.36 |
| 536.10 | 6.56 | 6.56 |
| 282.30 | 2.95 | 2.95 |
| 399.56 | 4.40 | 4.40 |
| 494.98 | 3.00 | 3.00 |
| 251.24 | 2.83 | 2.83 |
| 331.42 | 2.94 | 2.94 |
| 299.37 | 2.06 | 2.06 |
| 312.19 | 4.16 | 4.16 |
| 263.30 | 4.66 | 4.66 |
| 261.67 | 1.77 | 1.77 |
| 369.38 | 4.20 | 4.20 |
| 318.34 | 4.04 | 4.04 |
| 373.80 | 4.84 | 4.84 |
| 307.35 | 4.13 | 4.13 |
| 331.38 | 2.67 | 2.67 |
| 415.49 | 3.82 | 3.82 |
| 348.49 | 4.31 | 4.31 |
| 272.42 | 3.88 | 3.88 |
| 402.47 | 4.84 | 4.84 |
| 545.64 | 2.55 | 2.55 |
| 279.30 | 4.36 | 4.36 |
| 494.66 | 1.81 | 1.81 |
| 474.57 | 1.99 | 1.99 |
| 401.44 | 5.47 | 5.47 |
| 479.65 | 4.11 | 4.11 |
| 303.82 | 4.33 | 4.33 |
| 314.39 | 3.19 | 3.19 |
| 347.42 | 3.22 | 3.22 |
| 173.21 | 2.56 | 2.56 |
| 346.41 | 3.62 | 3.62 |
| 509.90 | 4.62 | 4.62 |
| 501.65 | 5.90 | 5.90 |
| 442.43 | 5.96 | 5.96 |
| 277.37 | 2.13 | 2.13 |
| 366.48 | 4.45 | 4.45 |
| 472.95 | 3.29 | 3.29 |
| 407.45 | 3.33 | 3.33 |
| 323.83 | 3.40 | 3.40 |
| 418.49 | 2.06 | 2.06 |
| 290.33 | 5.55 | 5.55 |
| 406.01 | 2.72 | 2.72 |
| 344.23 | 4.93 | 4.93 |
| 298.37 | 3.34 | 3.34 |
| 299.36 | 3.34 | 3.34 |
| 450.54 | 3.62 | 3.62 |
| 286.29 | 2.52 | 2.52 |
| 387.87 | 5.11 | 5.11 |
| 354.41 | 6.17 | 6.17 |
| 418.25 | 4.95 | 4.95 |
| 410.91 | 3.15 | 3.15 |
| 258.39 | 3.64 | 3.64 |
| 291.28 | 3.22 | 3.22 |
| 384.31 | 3.27 | 3.27 |
| 428.43 | 3.52 | 3.52 |
| 309.39 | 1.52 | 1.52 |
| 377.34 | 1.70 | 1.70 |
| 281.36 | 2.97 | 2.97 |
| 527.51 | 4.51 | 4.51 |
| 237.72 | 2.79 | 2.79 |
| 307.31 | 4.13 | 4.13 |
| 330.44 | 3.06 | 3.06 |
| 363.40 | 4.84 | 4.84 |
| 304.40 | 3.57 | 3.57 |
| 451.98 | 2.91 | 2.91 |
| 323.83 | 3.40 | 3.40 |
| 453.55 | 3.60 | 3.60 |
| 285.69 | 3.86 | 3.86 |
| 686.57 | 6.18 | 6.18 |
| 317.80 | 3.41 | 3.41 |
| 299.72 | 3.64 | 3.64 |
| 405.50 | 3.01 | 3.01 |
| 301.78 | 4.26 | 4.26 |
| 468.56 | 2.49 | 2.49 |
| 389.47 | 2.41 | 2.41 |
| 368.43 | 4.12 | 4.12 |
| 592.64 | 3.00 | 3.00 |
| 392.40 | 2.38 | 2.38 |
| 287.75 | 3.06 | 3.06 |
| 307.38 | 2.89 | 2.89 |
| 385.27 | 3.62 | 3.62 |
| 461.55 | 3.03 | 3.03 |
| 329.81 | 4.19 | 4.19 |
| 313.74 | 3.95 | 3.95 |
| 415.45 | 5.86 | 5.86 |
| 293.37 | 1.92 | 1.92 |
| 228.59 | 1.83 | 1.83 |
| 327.38 | 1.30 | 1.30 |
| 315.35 | 3.35 | 3.35 |
| 368.40 | 2.24 | 2.24 |
| 364.52 | 3.20 | 3.20 |
| 269.33 | 3.25 | 3.25 |
| 290.37 | 3.50 | 3.50 |
| 331.42 | 4.11 | 4.11 |
| 404.29 | 4.37 | 4.37 |
| 397.91 | 4.41 | 4.41 |
| 529.61 | 3.84 | 3.84 |
| 358.44 | 3.63 | 3.63 |
| 432.48 | 2.66 | 2.66 |
| 251.24 | 2.83 | 2.83 |
| 414.40 | 3.13 | 3.13 |
| 445.48 | 4.26 | 4.26 |
| 287.75 | 2.82 | 2.82 |
| 315.79 | 3.71 | 3.71 |
| 404.43 | 3.12 | 3.12 |
| 409.49 | 4.24 | 4.24 |
| 281.15 | 3.62 | 3.62 |
| 390.30 | 5.65 | 5.65 |
| 224.35 | 2.65 | 2.65 |
| 366.43 | 3.14 | 3.14 |
| 282.68 | 1.92 | 1.92 |
| 288.42 | 3.49 | 3.49 |
| 318.17 | 3.00 | 3.00 |
| 386.84 | 4.71 | 4.71 |
| 305.34 | 3.09 | 3.09 |
| 297.39 | 3.54 | 3.54 |
| 330.82 | 2.33 | 2.33 |
| 270.25 | 1.75 | 1.75 |
| 308.17 | 3.54 | 3.54 |
| 306.33 | 2.72 | 2.72 |
| 410.43 | 3.57 | 3.57 |
| 273.72 | 2.89 | 2.89 |
| 410.48 | 4.85 | 4.85 |
| 396.41 | 3.67 | 3.67 |
| 325.80 | 4.82 | 4.82 |
| 304.37 | 4.91 | 4.91 |
| 297.31 | 1.76 | 1.76 |
| 315.25 | 1.66 | 1.66 |
| 273.72 | 2.89 | 2.89 |
| 405.48 | 3.30 | 3.30 |
| 244.34 | 4.23 | 4.23 |
| 437.52 | 3.97 | 3.97 |
| 343.39 | 3.36 | 3.36 |
| 259.70 | 2.50 | 2.50 |
| 351.37 | 2.94 | 2.94 |
| 334.17 | 2.70 | 2.70 |
| 431.29 | 4.82 | 4.82 |
| 331.38 | 3.27 | 3.27 |
| 352.40 | 4.06 | 4.06 |
| 241.25 | 1.55 | 1.55 |
| 436.54 | 4.14 | 4.14 |
| 319.34 | 3.40 | 3.40 |
| 284.28 | 2.06 | 2.06 |
| 320.15 | 2.31 | 2.31 |
| 328.33 | 2.30 | 2.30 |
| 343.37 | 4.28 | 4.28 |