Basic Information
ID: ALA1614408
Type: Functional
Description: PUBCHEM_BIOASSAY: Counterscreen for NR2E3 inverse agonists: TR-FRET-based biochemical high throughput dose response assay to identify inverse agonists of the interaction between peroxisome proliferator-activated receptor gamma (PPARg) and nuclear receptor co-repressor 2 (NCOR2). (Class of assay: confirmatory) [Related pubchem assays: 2379 (Confirmation (NR2E3 agonists in quadruplicate)), 2759 (Dose response counterscreen (PPARg and NCOR2 interaction agonists in triplicate)), 2758 (Dose response (NR2E3 agonists in quadruplicate)), 2325 (Summary (NR2E3 agonists)), 2300 (Primary screen (NR2E3 agonists in singlicate))]
Format: BAO_0000019
Organism: Homo sapiens
Target: Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2(ALA2096976)
Document: ALA1201862
PubChem Source: AID:463257
Activity Charts
Bioactivity
Activity Types for Assay ALA1614408
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 333.41 | 2.57 | 2.57 |
| 349.39 | 1.73 | 1.73 |
| 444.54 | 5.86 | 5.86 |
| 450.52 | 4.60 | 4.60 |
| 490.49 | 2.59 | 2.59 |
| 483.59 | 6.16 | 6.16 |
| 422.54 | 4.74 | 4.74 |
| 360.46 | 2.70 | 2.70 |
| 363.44 | 3.54 | 3.54 |
| 401.88 | 3.88 | 3.88 |
| 301.43 | 2.41 | 2.41 |
| 347.30 | 4.40 | 4.40 |
| 363.19 | 4.33 | 4.33 |
| 333.39 | 2.79 | 2.79 |
| 376.80 | 4.76 | 4.76 |
| 330.37 | 2.88 | 2.88 |
| 390.51 | 3.92 | 3.92 |
| 372.47 | 4.12 | 4.12 |
| 310.74 | 3.44 | 3.44 |
| 409.52 | 4.56 | 4.56 |
| 462.51 | 5.81 | 5.81 |
| 404.49 | 4.91 | 4.91 |
| 392.48 | 2.40 | 2.40 |
| 458.56 | 3.39 | 3.39 |
| 340.38 | 5.05 | 5.05 |
| 459.33 | 4.30 | 4.30 |
| 407.45 | 3.81 | 3.81 |
| 380.76 | 3.87 | 3.87 |
| 452.92 | 3.53 | 3.53 |
| 393.30 | 4.84 | 4.84 |
| 377.24 | 1.97 | 1.97 |
| 419.34 | 4.88 | 4.88 |
| 265.41 | 3.19 | 3.19 |
| 373.37 | 3.91 | 3.91 |
| 379.51 | 3.16 | 3.16 |
| 418.32 | 3.99 | 3.99 |
| 435.33 | 4.64 | 4.64 |
| 338.39 | 3.98 | 3.98 |
| 343.41 | 3.05 | 3.05 |
| 521.67 | 4.76 | 4.76 |
| 319.46 | 3.31 | 3.31 |
| 355.44 | 4.48 | 4.48 |
| 412.31 | 3.65 | 3.65 |
| 257.33 | 3.09 | 3.09 |
| 217.25 | 2.66 | 2.66 |
| 347.44 | 3.06 | 3.06 |
| 366.42 | 4.47 | 4.47 |
| 469.99 | 3.86 | 3.86 |
| 484.60 | 4.28 | 4.28 |
| 473.49 | 6.22 | 6.22 |
| 383.45 | 4.24 | 4.24 |
| 275.31 | 3.96 | 3.96 |
| 318.83 | 4.13 | 4.13 |
| 314.80 | 4.72 | 4.72 |
| 444.13 | 5.32 | 5.32 |
| 384.19 | 4.50 | 4.50 |
| 419.49 | 1.74 | 1.74 |
| 389.84 | 4.51 | 4.51 |
| 427.30 | 4.74 | 4.74 |
| 306.77 | 4.41 | 4.41 |
| 224.31 | 2.77 | 2.77 |
| 395.48 | 4.26 | 4.26 |
| 463.72 | 5.60 | 5.60 |
| 353.40 | 3.66 | 3.66 |
| 428.49 | 3.68 | 3.68 |
| 366.83 | 4.66 | 4.66 |
| 372.38 | 4.78 | 4.78 |
| 379.81 | 3.71 | 3.71 |
| 388.47 | 3.35 | 3.35 |
| 368.55 | 5.26 | 5.26 |
| 366.83 | 4.66 | 4.66 |
| 380.44 | 3.93 | 3.93 |
| 438.53 | 4.40 | 4.40 |
| 497.65 | 6.45 | 6.45 |
| 327.39 | 4.27 | 4.27 |
| 293.31 | 3.03 | 3.03 |
| 380.47 | 2.62 | 2.62 |
| 352.46 | 3.98 | 3.98 |
| 507.64 | 4.41 | 4.41 |
| 299.29 | 2.90 | 2.90 |
| 384.19 | 3.40 | 3.40 |
| 318.45 | 4.24 | 4.24 |
| 355.32 | 1.45 | 1.45 |
| 393.36 | 1.91 | 1.91 |
| 474.54 | 3.16 | 3.16 |
| 374.19 | 3.76 | 3.76 |
| 419.55 | 4.95 | 4.95 |
| 363.80 | 4.72 | 4.72 |
| 342.44 | 2.04 | 2.04 |
| 369.27 | 4.38 | 4.38 |
| 315.38 | 4.06 | 4.06 |
| 319.32 | 2.97 | 2.97 |
| 305.30 | 2.66 | 2.66 |
| 372.45 | 2.94 | 2.94 |
| 329.36 | 4.07 | 4.07 |
| 498.56 | 2.93 | 2.93 |
| 360.48 | 2.85 | 2.85 |
| 345.35 | 4.21 | 4.21 |
| 489.58 | 4.58 | 4.58 |
| 375.84 | 3.00 | 3.00 |
| 352.84 | 4.11 | 4.11 |
| 409.60 | 2.78 | 2.78 |
| 392.51 | 4.73 | 4.73 |
| 333.48 | 3.70 | 3.70 |
| 394.40 | 3.46 | 3.46 |
| 397.50 | 5.03 | 5.03 |
| 368.41 | 4.37 | 4.37 |
| 431.51 | 1.97 | 1.97 |
| 387.85 | 3.02 | 3.02 |
| 443.33 | 4.72 | 4.72 |
| 378.48 | 4.48 | 4.48 |
| 382.42 | 4.10 | 4.10 |
| 326.36 | 3.67 | 3.67 |
| 354.35 | 4.54 | 4.54 |