Basic Information
ID: ALA1614466
Type: Functional
Description: PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) [Related pubchem assays: 1705 (qHTS Validation Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) ), 2324 (Probe Development Summary of Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)), 1707 (Counterscreen for APE1 Inhibitors: Fluorescent Dye Displacement Validation Assay), 2517 (qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)), 1708 (Counterscreen for APE1 Inhibitors: qHTS Validation Assay for Inhibitors of Endonuclease IV)]
Format: BAO_0000019
Organism: Homo sapiens
Target: DNA-(apurinic or apyrimidinic site) lyase(ALA5619)
Document: ALA1201862
PubChem Source: AID:2572
Activity Charts
Bioactivity
Activity Types for Assay ALA1614466
Potency
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 562.67 | 7.50 | 7.50 |
| 272.21 | 1.28 | 1.28 |
| 300.22 | 1.28 | 1.28 |
| 308.31 | 2.76 | 2.76 |
| 458.38 | 2.23 | 2.23 |
| 316.26 | 2.29 | 2.29 |
| 472.36 | 2.23 | 2.23 |
| 650.76 | 3.93 | 3.93 |
| 311.38 | 2.86 | 2.86 |
| 347.22 | 2.29 | 2.29 |
| 310.39 | 4.45 | 4.45 |
| 1505.11 | ||
| 449.53 | 3.77 | 3.77 |
| 231.21 | 1.87 | 1.87 |
| 442.95 | 2.66 | 2.66 |
| 346.34 | -0.06 | -0.06 |
| 300.34 | 3.37 | 3.37 |
| 834.81 | 3.86 | 3.86 |
| 381.84 | 4.18 | 4.18 |
| 373.43 | 1.62 | 1.62 |
| 389.44 | 2.63 | 2.63 |
| 194.22 | 1.21 | 1.21 |
| 428.24 | 3.37 | 3.37 |
| 468.68 | 6.62 | 6.62 |
| 224.33 | 3.87 | 3.87 |
| 403.46 | 4.57 | 4.57 |
| 290.38 | 2.69 | 2.69 |
| 484.50 | -0.23 | -0.23 |
| 250.71 | 2.65 | 2.65 |
| 904.89 | 6.07 | 6.07 |
| 269.21 | 2.08 | 2.08 |
| 345.36 | 3.06 | 3.06 |
| 356.33 | 2.27 | 2.27 |
| 217.22 | 2.20 | 2.20 |
| 275.26 | 1.75 | 1.75 |
| 295.34 | 2.42 | 2.42 |
| 381.43 | 3.59 | 3.59 |
| 523.60 | 3.33 | 3.33 |
| 218.25 | 1.74 | 1.74 |
| 264.31 | 2.26 | 2.26 |
| 249.23 | 1.22 | 1.22 |
| 331.17 | 3.41 | 3.41 |
| 594.52 | -1.39 | -1.39 |
| 287.36 | 2.97 | 2.97 |
| 398.28 | 3.30 | 3.30 |
| 304.37 | 2.26 | 2.26 |
| 318.24 | 1.69 | 1.69 |
| 408.42 | 4.65 | 4.65 |
| 476.51 | 4.94 | 4.94 |
| 400.49 | 4.07 | 4.07 |
| 426.56 | 4.02 | 4.02 |
| 290.37 | 3.57 | 3.57 |
| 199.30 | 1.96 | 1.96 |
| 345.38 | 2.80 | 2.80 |
| 301.39 | 4.18 | 4.18 |
| 341.15 | 3.18 | 3.18 |
| 564.50 | 2.21 | 2.21 |
| 333.32 | 4.28 | 4.28 |
| 524.60 | 4.17 | 4.17 |
| 426.52 | 2.73 | 2.73 |
| 347.39 | 1.90 | 1.90 |
| 458.59 | 4.59 | 4.59 |
| 433.42 | 3.05 | 3.05 |
| 542.59 | 3.91 | 3.91 |
| 564.50 | -1.75 | -1.75 |
| 331.71 | 3.61 | 3.61 |
| 365.41 | 3.03 | 3.03 |
| 285.73 | -0.78 | -0.78 |
| 326.31 | 1.95 | 1.95 |
| 262.22 | 1.10 | 1.10 |
| 465.51 | 2.92 | 2.92 |
| 383.43 | 2.90 | 2.90 |
| 410.45 | 4.86 | 4.86 |
| 385.45 | 2.35 | 2.35 |
| 491.74 | 4.12 | 4.12 |
| 288.22 | -0.04 | -0.04 |
| 368.42 | 2.91 | 2.91 |
| 286.26 | 2.51 | 2.51 |
| 243.26 | 2.60 | 2.60 |
| 326.30 | 3.15 | 3.15 |
| 331.44 | 5.28 | 5.28 |
| 416.41 | 5.02 | 5.02 |
| 325.39 | 3.93 | 3.93 |
| 288.32 | 3.18 | 3.18 |
| 275.30 | 1.65 | 1.65 |
| 299.31 | 1.86 | 1.86 |
| 286.29 | 2.55 | 2.55 |
| 355.35 | 1.38 | 1.38 |
| 375.41 | 2.36 | 2.36 |
| 427.37 | 1.73 | 1.73 |
| 277.24 | -0.04 | -0.04 |
| 279.32 | 1.39 | 1.39 |
| 387.40 | 3.27 | 3.27 |
| 360.43 | 2.09 | 2.09 |
| 378.41 | 0.79 | 0.79 |
| 205.18 | 0.62 | 0.62 |
| 264.27 | 2.20 | 2.20 |
| 412.42 | 3.24 | 3.24 |
| 379.38 | 0.07 | 0.07 |
| 770.73 | -6.34 | -6.34 |