Basic Information
ID: ALA1764271
Type: ADME
Description: Inhibition of human CYP3A4 in human liver microsomes assessed as formation of 6beta-hydroxy-testosterone using testosterone as substrate by high throughput mass spectrometry preincubated for 30 mins in presence of NADPH
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsome
Activity Charts
Bioactivity
Activity Types for Assay ALA1764271
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 734.76 | 8.30 | 8.30 |
| 699.72 | 7.25 | 7.25 |
| 712.76 | 7.16 | 7.16 |
| 776.82 | 6.54 | 6.54 |
| 769.81 | 7.31 | 7.31 |
| 713.74 | 7.37 | 7.37 |
| 767.79 | 7.80 | 7.80 |
| 739.74 | 7.32 | 7.32 |
| 753.76 | 7.86 | 7.86 |
| 741.75 | 7.71 | 7.71 |
| 755.78 | 8.10 | 8.10 |
| 769.81 | 8.49 | 8.49 |
| 783.83 | 8.88 | 8.88 |
| 781.82 | 8.64 | 8.64 |
| 771.78 | 7.48 | 7.48 |
| 816.84 | 6.31 | 6.31 |
| 777.79 | 7.14 | 7.14 |