Basic Information
ID: ALA1780631
Type: Functional
Description: In vivo inhibition of squalene synthase in NMRI rat assessed as inhibition of hepatic [14C]cholesterol biosynthesis at 3 mg/kg, po measured after 1 hr by liquid scintillation counting
Format: BAO_0000218
Organism: Rattus norvegicus
Strain: NMRI
Target: Rattus norvegicus(ALA376)
Document: ALA1777787
In vivo inhibition of squalene synthase in NMRI rat assessed as inhibition of hepatic [14C]cholesterol biosynthesis at 3 mg/kg, po measured after 1 hr by liquid scintillation counting: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA1780631
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 603.11 | 4.30 | 4.30 |
| 645.15 | 4.87 | 4.87 |
| 457.91 | 5.77 | 5.77 |
| 457.91 | 5.77 | 5.77 |
| 457.91 | 5.77 | 5.77 |
| 527.02 | 5.28 | 5.28 |
| 583.08 | 6.40 | 6.40 |
| 569.05 | 6.01 | 6.01 |
| 477.94 | 3.67 | 3.67 |