Basic Information
ID: ALA1789906
Type: Functional
Description: NOVARTIS: Antimalarial liver stage activity measured as reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells by immuno-fluorescence, and median schizont size at 10uM compound concentration
Organism: Plasmodium yoelii
Cell type: HepG2-A16-CD81
Activity Charts
Bioactivity
Activity Types for Assay ALA1789906
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 248.72 | 2.52 | 2.52 |
| 399.97 | 5.97 | 5.97 |
| 371.82 | 3.10 | 3.10 |
| 480.65 | 4.94 | 4.94 |
| 248.24 | 1.93 | 1.93 |
| 368.48 | 4.88 | 4.88 |
| 281.35 | 1.04 | 1.04 |
| 527.58 | 6.17 | 6.17 |
| 244.69 | 2.53 | 2.53 |
| 259.31 | 3.24 | 3.24 |
| 395.26 | 5.34 | 5.34 |
| 225.25 | 2.69 | 2.69 |
| 434.54 | 4.11 | 4.11 |
| 406.49 | 6.59 | 6.59 |
| 454.32 | 3.80 | 3.80 |
| 293.37 | 3.60 | 3.60 |
| 237.26 | 3.08 | 3.08 |
| 252.11 | 2.91 | 2.91 |
| 333.22 | 5.60 | 5.60 |
| 297.79 | 1.27 | 1.27 |
| 426.35 | 5.04 | 5.04 |
| 347.46 | 6.00 | 6.00 |
| 419.87 | 3.98 | 3.98 |
| 434.54 | 3.95 | 3.95 |
| 328.40 | 4.70 | 4.70 |
| 419.93 | 5.32 | 5.32 |
| 349.26 | 3.65 | 3.65 |
| 372.45 | 3.19 | 3.19 |
| 316.79 | 2.78 | 2.78 |
| 464.49 | 5.54 | 5.54 |
| 448.91 | 5.13 | 5.13 |
| 517.11 | 4.94 | 4.94 |
| 341.44 | 5.94 | 5.94 |
| 346.82 | 2.79 | 2.79 |
| 444.27 | 6.03 | 6.03 |
| 456.51 | 4.03 | 4.03 |
| 319.36 | 3.47 | 3.47 |
| 475.38 | 8.55 | 8.55 |
| 360.50 | 5.01 | 5.01 |
| 483.52 | 5.98 | 5.98 |
| 336.39 | 3.67 | 3.67 |
| 400.87 | 3.78 | 3.78 |
| 336.35 | 3.68 | 3.68 |
| 475.38 | 8.55 | 8.55 |
| 321.42 | 3.88 | 3.88 |
| 253.74 | 0.87 | 0.87 |
| 402.88 | 5.04 | 5.04 |
| 238.08 | 2.60 | 2.60 |
| 354.42 | 4.29 | 4.29 |
| 430.52 | 5.22 | 5.22 |
| 683.52 | 6.88 | 6.88 |
| 322.45 | 4.08 | 4.08 |
| 267.76 | 1.18 | 1.18 |
| 315.80 | 4.01 | 4.01 |
| 288.35 | 3.77 | 3.77 |
| 379.63 | 1.48 | 1.48 |
| 440.54 | 4.64 | 4.64 |
| 334.78 | 2.92 | 2.92 |
| 288.18 | 1.53 | 1.53 |
| 363.37 | 2.38 | 2.38 |
| 427.51 | 4.59 | 4.59 |
| 391.56 | 5.15 | 5.15 |
| 311.47 | 4.74 | 4.74 |
| 443.53 | 4.44 | 4.44 |
| 304.32 | 2.75 | 2.75 |
| 404.90 | 4.00 | 4.00 |
| 518.57 | 6.93 | 6.93 |
| 411.55 | 3.75 | 3.75 |
| 247.25 | 2.13 | 2.13 |
| 344.21 | 3.74 | 3.74 |
| 387.27 | 5.23 | 5.23 |
| 265.70 | 3.07 | 3.07 |
| 378.41 | 4.51 | 4.51 |
| 356.43 | 4.99 | 4.99 |
| 405.50 | 3.62 | 3.62 |
| 359.43 | 5.61 | 5.61 |
| 352.37 | 3.03 | 3.03 |
| 316.31 | 2.56 | 2.56 |
| 394.48 | 3.57 | 3.57 |
| 357.42 | 4.46 | 4.46 |
| 399.31 | 2.53 | 2.53 |
| 471.48 | 4.00 | 4.00 |
| 411.46 | 5.57 | 5.57 |
| 440.46 | 5.47 | 5.47 |
| 392.89 | 4.99 | 4.99 |
| 502.31 | 3.27 | 3.27 |
| 404.30 | 3.81 | 3.81 |
| 199.25 | 2.41 | 2.41 |
| 550.53 | 6.54 | 6.54 |
| 436.58 | 4.46 | 4.46 |
| 255.36 | 3.68 | 3.68 |
| 303.43 | 4.96 | 4.96 |
| 378.49 | 4.12 | 4.12 |
| 282.77 | 5.25 | 5.25 |
| 473.00 | 4.06 | 4.06 |
| 590.41 | 6.67 | 6.67 |
| 407.56 | 6.64 | 6.64 |
| 326.23 | 2.33 | 2.33 |
| 455.21 | 5.44 | 5.44 |
| 388.52 | 4.31 | 4.31 |
| 272.38 | 3.56 | 3.56 |
| 437.57 | 4.69 | 4.69 |
| 370.82 | 4.72 | 4.72 |
| 406.53 | 6.42 | 6.42 |
| 293.33 | 3.22 | 3.22 |
| 351.28 | 4.46 | 4.46 |
| 471.07 | 5.42 | 5.42 |
| 274.39 | 3.85 | 3.85 |
| 392.41 | 3.81 | 3.81 |
| 448.52 | 3.84 | 3.84 |
| 329.40 | 3.84 | 3.84 |
| 391.47 | 6.00 | 6.00 |
| 432.45 | 2.40 | 2.40 |
| 490.67 | 4.92 | 4.92 |
| 428.56 | 4.99 | 4.99 |
| 579.65 | 4.43 | 4.43 |
| 377.28 | 3.68 | 3.68 |
| 344.47 | 4.59 | 4.59 |
| 326.40 | 4.99 | 4.99 |
| 433.26 | 2.54 | 2.54 |
| 548.69 | 8.29 | 8.29 |
| 283.42 | 4.75 | 4.75 |
| 763.73 | 5.74 | 5.74 |
| 344.39 | 5.12 | 5.12 |
| 301.82 | 2.74 | 2.74 |
| 331.40 | 5.53 | 5.53 |
| 411.53 | 3.97 | 3.97 |
| 532.64 | 4.49 | 4.49 |
| 282.17 | 4.42 | 4.42 |
| 384.31 | 3.95 | 3.95 |
| 408.31 | 3.73 | 3.73 |
| 321.83 | 4.26 | 4.26 |
| 296.11 | 4.13 | 4.13 |
| 231.40 | 2.37 | 2.37 |
| 294.19 | 4.35 | 4.35 |
| 419.87 | 4.52 | 4.52 |
| 268.14 | 4.11 | 4.11 |
| 472.41 | 4.79 | 4.79 |
| 338.37 | 3.78 | 3.78 |
| 283.76 | 0.88 | 0.88 |
| 326.38 | 3.62 | 3.62 |
| 579.65 | 4.43 | 4.43 |
| 293.32 | 3.78 | 3.78 |
| 348.79 | 5.00 | 5.00 |
| 359.43 | 5.61 | 5.61 |
| 201.27 | 3.20 | 3.20 |
| 410.48 | 3.82 | 3.82 |
| 315.21 | 4.88 | 4.88 |
| 262.40 | 3.40 | 3.40 |
| 504.50 | 5.55 | 5.55 |
| 381.40 | 0.99 | 0.99 |
| 720.83 | 10.84 | 10.84 |
| 463.54 | 5.91 | 5.91 |
| 321.12 | 3.29 | 3.29 |
| 347.42 | 2.83 | 2.83 |
| 380.85 | 5.12 | 5.12 |
| 641.84 | 5.01 | 5.01 |
| 415.45 | 3.77 | 3.77 |
| 432.57 | 3.84 | 3.84 |
| 370.33 | 4.38 | 4.38 |
| 319.36 | 5.56 | 5.56 |
| 319.86 | 4.43 | 4.43 |
| 351.19 | 3.79 | 3.79 |
| 400.48 | 3.51 | 3.51 |
| 510.97 | 4.92 | 4.92 |
| 375.47 | 5.23 | 5.23 |
| 541.71 | 8.00 | 8.00 |
| 495.34 | 6.15 | 6.15 |
| 312.44 | 2.48 | 2.48 |
| 318.42 | 4.76 | 4.76 |
| 368.23 | 4.22 | 4.22 |
| 434.61 | 6.32 | 6.32 |
| 281.27 | 2.60 | 2.60 |
| 436.38 | 4.79 | 4.79 |
| 373.32 | 3.85 | 3.85 |
| 438.19 | 4.30 | 4.30 |
| 464.59 | 3.97 | 3.97 |
| 412.58 | 3.75 | 3.75 |
| 336.39 | 3.63 | 3.63 |
| 407.52 | 4.17 | 4.17 |
| 340.43 | 4.84 | 4.84 |
| 549.62 | 4.43 | 4.43 |
| 552.73 | 6.03 | 6.03 |
| 345.25 | 3.26 | 3.26 |
| 313.81 | 5.32 | 5.32 |
| 491.57 | 6.46 | 6.46 |
| 213.21 | 2.82 | 2.82 |
| 375.26 | 4.86 | 4.86 |
| 379.26 | 3.21 | 3.21 |
| 391.43 | 2.32 | 2.32 |
| 531.67 | 5.55 | 5.55 |
| 384.52 | 3.17 | 3.17 |
| 549.64 | 4.31 | 4.31 |
| 470.97 | 5.88 | 5.88 |
| 226.75 | 2.65 | 2.65 |
| 371.46 | 5.95 | 5.95 |
| 472.57 | 5.15 | 5.15 |
| 543.93 | 10.27 | 10.27 |
| 416.70 | 7.70 | 7.70 |
| 360.59 | 6.13 | 6.13 |
| 723.96 | 11.37 | 11.37 |
| 341.44 | 4.08 | 4.08 |
| 253.31 | 3.03 | 3.03 |
| 336.41 | 1.98 | 1.98 |
| 575.07 | 5.66 | 5.66 |
| 339.35 | 2.27 | 2.27 |
| 420.04 | 5.44 | 5.44 |
| 399.88 | 5.05 | 5.05 |
| 449.30 | 5.03 | 5.03 |
| 447.54 | 3.74 | 3.74 |
| 383.54 | 4.08 | 4.08 |
| 479.17 | 1.97 | 1.97 |
| 497.66 | 8.62 | 8.62 |
| 450.65 | 4.62 | 4.62 |
| 410.34 | 4.58 | 4.58 |
| 291.46 | 3.80 | 3.80 |
| 406.49 | 6.59 | 6.59 |
| 538.74 | 8.34 | 8.34 |
| 320.45 | -1.91 | -1.91 |
| 413.26 | 3.96 | 3.96 |
| 497.02 | 3.81 | 3.81 |
| 471.56 | 6.59 | 6.59 |
| 271.32 | 3.00 | 3.00 |
| 301.41 | 3.91 | 3.91 |
| 396.28 | 5.84 | 5.84 |
| 516.25 | 2.47 | 2.47 |
| 298.82 | 3.65 | 3.65 |
| 420.33 | 6.70 | 6.70 |
| 452.89 | 4.78 | 4.78 |
| 447.56 | 7.13 | 7.13 |
| 424.45 | 4.52 | 4.52 |
| 534.57 | 4.32 | 4.32 |
| 292.33 | 2.53 | 2.53 |
| 296.11 | 4.13 | 4.13 |
| 624.96 | 9.94 | 9.94 |
| 281.31 | 3.94 | 3.94 |
| 277.33 | 3.52 | 3.52 |
| 295.81 | 3.61 | 3.61 |
| 316.47 | 3.09 | 3.09 |
| 481.56 | 3.93 | 3.93 |
| 433.56 | 4.28 | 4.28 |
| 355.46 | 6.25 | 6.25 |
| 475.59 | 5.33 | 5.33 |
| 163.22 | 2.21 | 2.21 |
| 373.39 | 1.28 | 1.28 |
| 365.55 | 5.40 | 5.40 |
| 638.27 | 8.49 | 8.49 |
| 303.37 | 4.51 | 4.51 |
| 465.48 | 4.37 | 4.37 |
| 360.42 | 4.98 | 4.98 |
| 363.37 | 1.51 | 1.51 |
| 532.59 | 5.46 | 5.46 |
| 292.39 | -2.69 | -2.69 |
| 191.26 | -0.19 | -0.19 |
| 336.42 | 3.25 | 3.25 |
| 317.46 | 4.78 | 4.78 |
| 532.08 | 6.98 | 6.98 |
| 410.86 | 3.32 | 3.32 |
| 262.32 | 3.96 | 3.96 |
| 356.54 | 5.03 | 5.03 |
| 517.10 | 5.13 | 5.13 |
| 342.42 | 4.09 | 4.09 |
| 271.73 | 1.01 | 1.01 |
| 635.63 | 3.40 | 3.40 |
| 193.17 | -1.63 | -1.63 |
| 310.42 | 2.65 | 2.65 |
| 308.36 | 4.28 | 4.28 |
| 645.31 | 6.33 | 6.33 |
| 406.92 | 5.38 | 5.38 |
| 393.60 | 4.91 | 4.91 |
| 311.47 | 4.59 | 4.59 |
| 419.55 | 4.70 | 4.70 |
| 340.43 | 4.57 | 4.57 |
| 476.54 | 6.83 | 6.83 |
| 389.57 | 6.29 | 6.29 |
| 413.86 | 6.40 | 6.40 |
| 227.31 | 3.19 | 3.19 |
| 257.30 | 2.26 | 2.26 |
| 399.36 | 5.40 | 5.40 |
| 320.49 | 3.67 | 3.67 |
| 372.47 | 4.46 | 4.46 |
| 320.40 | 4.15 | 4.15 |
| 530.58 | 6.94 | 6.94 |
| 549.89 | 8.47 | 8.47 |
| 395.47 | 3.32 | 3.32 |
| 294.19 | 4.21 | 4.21 |
| 314.34 | 1.09 | 1.09 |
| 233.27 | 3.21 | 3.21 |
| 522.48 | 5.55 | 5.55 |
| 460.34 | 6.50 | 6.50 |
| 426.51 | 4.91 | 4.91 |
| 234.21 | -0.38 | -0.38 |
| 526.00 | 5.45 | 5.45 |
| 637.73 | 5.50 | 5.50 |
| 570.20 | 6.45 | 6.45 |
| 455.03 | 6.92 | 6.92 |
| 432.55 | 5.49 | 5.49 |
| 423.47 | 3.40 | 3.40 |
| 595.51 | 6.05 | 6.05 |
| 372.44 | 3.69 | 3.69 |
| 273.34 | 4.14 | 4.14 |
| 333.35 | 3.47 | 3.47 |
| 340.43 | 5.29 | 5.29 |
| 509.19 | 4.08 | 4.08 |
| 245.32 | 3.60 | 3.60 |
| 279.34 | 3.29 | 3.29 |
| 441.55 | 3.23 | 3.23 |
| 373.41 | 4.52 | 4.52 |
| 434.61 | 5.61 | 5.61 |
| 298.34 | 1.85 | 1.85 |
| 283.33 | 2.91 | 2.91 |
| 287.39 | 2.03 | 2.03 |
| 356.47 | 2.18 | 2.18 |
| 367.84 | 3.76 | 3.76 |
| 414.72 | 3.97 | 3.97 |
| 278.15 | 3.74 | 3.74 |
| 267.76 | 1.18 | 1.18 |
| 410.27 | 5.20 | 5.20 |
| 471.04 | 5.15 | 5.15 |
| 281.40 | 3.91 | 3.91 |
| 328.45 | 5.14 | 5.14 |
| 223.30 | 3.09 | 3.09 |
| 354.84 | 4.60 | 4.60 |
| 524.58 | 7.52 | 7.52 |
| 418.07 | 6.61 | 6.61 |
| 384.47 | 4.16 | 4.16 |
| 329.31 | 1.14 | 1.14 |
| 365.17 | 3.32 | 3.32 |
| 492.42 | 3.33 | 3.33 |
| 307.44 | 4.84 | 4.84 |
| 489.73 | 3.68 | 3.68 |
| 268.36 | 2.69 | 2.69 |
| 379.42 | 4.24 | 4.24 |
| 501.62 | 5.86 | 5.86 |
| 520.54 | 4.61 | 4.61 |
| 491.58 | 5.87 | 5.87 |
| 487.65 | 7.32 | 7.32 |
| 566.02 | 5.89 | 5.89 |