Basic Information
ID: ALA1794413
Type: Functional
Description: PUBCHEM_BIOASSAY: Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID489030, AID492945]
Activity Charts
Bioactivity
Activity Types for Assay ALA1794413
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 252.32 | 2.74 | 2.74 |
| 279.34 | 3.17 | 3.17 |
| 208.22 | 2.73 | 2.73 |
| 249.27 | 2.91 | 2.91 |
| 223.23 | 2.31 | 2.31 |
| 520.50 | 3.30 | 3.30 |
| 492.45 | 5.70 | 5.70 |
| 337.81 | 4.43 | 4.43 |
| 272.31 | 3.66 | 3.66 |
| 289.34 | 0.64 | 0.64 |
| 280.33 | 2.29 | 2.29 |
| 328.35 | 1.55 | 1.55 |
| 294.35 | 4.25 | 4.25 |
| 353.37 | 3.50 | 3.50 |
| 448.09 | 6.07 | 6.07 |
| 505.62 | 5.52 | 5.52 |
| 310.40 | 1.73 | 1.73 |
| 430.53 | 4.62 | 4.62 |
| 319.86 | 2.50 | 2.50 |
| 370.45 | 4.38 | 4.38 |
| 579.99 | 0.00 | 0.00 |
| 506.48 | 6.09 | 6.09 |
| 328.42 | 4.04 | 4.04 |
| 223.23 | 2.51 | 2.51 |
| 442.49 | 4.30 | 4.30 |
| 362.43 | 3.88 | 3.88 |
| 346.43 | 4.18 | 4.18 |
| 229.28 | 2.18 | 2.18 |
| 300.36 | 2.14 | 2.14 |
| 207.19 | -1.32 | -1.32 |
| 332.40 | 3.88 | 3.88 |
| 476.54 | 6.83 | 6.83 |
| 309.33 | 1.03 | 1.03 |
| 290.32 | 3.66 | 3.66 |
| 444.54 | 5.86 | 5.86 |
| 418.07 | 6.61 | 6.61 |
| 284.27 | 2.54 | 2.54 |
| 410.39 | 3.49 | 3.49 |
| 420.42 | 2.36 | 2.36 |
| 410.39 | 3.49 | 3.49 |
| 266.23 | 2.07 | 2.07 |
| 591.72 | 8.05 | 8.05 |
| 687.71 | 10.29 | 10.29 |
| 313.77 | 3.57 | 3.57 |
| 327.38 | 2.77 | 2.77 |
| 420.40 | 2.98 | 2.98 |
| 309.41 | 4.63 | 4.63 |
| 323.44 | 5.02 | 5.02 |
| 337.47 | 5.41 | 5.41 |
| 445.51 | 2.63 | 2.63 |
| 390.86 | 4.47 | 4.47 |
| 409.46 | 2.95 | 2.95 |
| 369.76 | 3.27 | 3.27 |
| 421.48 | 3.37 | 3.37 |
| 264.21 | 3.67 | 3.67 |
| 443.58 | 4.80 | 4.80 |
| 441.58 | 3.92 | 3.92 |
| 277.33 | 3.49 | 3.49 |
| 322.39 | 3.98 | 3.98 |
| 473.06 | 5.73 | 5.73 |
| 298.73 | 2.70 | 2.70 |
| 366.98 | 5.36 | 5.36 |
| 514.61 | 5.39 | 5.39 |
| 367.45 | 2.87 | 2.87 |
| 336.32 | 3.15 | 3.15 |
| 236.20 | 3.86 | 3.86 |
| 343.41 | 2.82 | 2.82 |
| 547.43 | 3.29 | 3.29 |
| 462.12 | 6.38 | 6.38 |
| 344.38 | 4.41 | 4.41 |
| 300.32 | 2.61 | 2.61 |
| 413.30 | 4.45 | 4.45 |
| 503.08 | 5.74 | 5.74 |
| 190.15 | 1.39 | 1.39 |
| 494.04 | 3.14 | 3.14 |
| 424.50 | 3.61 | 3.61 |
| 357.37 | 3.51 | 3.51 |
| 436.90 | 4.15 | 4.15 |
| 458.26 | 4.01 | 4.01 |
| 265.31 | 2.45 | 2.45 |
| 336.35 | 2.81 | 2.81 |
| 544.40 | 3.70 | 3.70 |
| 420.47 | 4.80 | 4.80 |
| 320.78 | 1.44 | 1.44 |
| 306.32 | 2.29 | 2.29 |
| 503.08 | 5.74 | 5.74 |
| 375.38 | 3.30 | 3.30 |
| 471.89 | 4.26 | 4.26 |
| 484.51 | 6.25 | 6.25 |
| 457.56 | 4.60 | 4.60 |
| 420.83 | 4.61 | 4.61 |
| 490.59 | 5.01 | 5.01 |
| 256.21 | 2.06 | 2.06 |
| 430.91 | 3.40 | 3.40 |
| 416.86 | 4.78 | 4.78 |
| 326.36 | 2.19 | 2.19 |
| 408.41 | 3.39 | 3.39 |
| 411.48 | 1.50 | 1.50 |
| 438.67 | 6.28 | 6.28 |
| 276.30 | 3.52 | 3.52 |
| 443.53 | 4.04 | 4.04 |
| 590.47 | 4.11 | 4.11 |
| 439.50 | 0.61 | 0.61 |
| 402.84 | 4.47 | 4.47 |
| 380.54 | 4.95 | 4.95 |
| 370.28 | 4.30 | 4.30 |
| 348.40 | 3.03 | 3.03 |
| 212.64 | 1.52 | 1.52 |
| 458.51 | 1.15 | 1.15 |
| 468.51 | 2.45 | 2.45 |
| 487.08 | 6.04 | 6.04 |
| 558.43 | 4.23 | 4.23 |
| 463.56 | 4.14 | 4.14 |
| 468.29 | 3.57 | 3.57 |
| 406.53 | 3.95 | 3.95 |
| 491.98 | 4.86 | 4.86 |
| 309.32 | 1.80 | 1.80 |
| 349.26 | 2.20 | 2.20 |
| 238.68 | 2.06 | 2.06 |
| 397.44 | 2.34 | 2.34 |
| 322.36 | 2.28 | 2.28 |
| 229.33 | 3.70 | 3.70 |
| 483.58 | 6.94 | 6.94 |
| 400.31 | 4.31 | 4.31 |
| 243.19 | 2.21 | 2.21 |
| 230.09 | 2.04 | 2.04 |
| 297.75 | 2.76 | 2.76 |
| 252.36 | 4.73 | 4.73 |
| 338.36 | 1.98 | 1.98 |
| 302.36 | 3.63 | 3.63 |
| 316.41 | 3.73 | 3.73 |
| 485.54 | 3.99 | 3.99 |
| 392.55 | 4.95 | 4.95 |
| 241.29 | 2.28 | 2.28 |
| 493.50 | 3.54 | 3.54 |
| 236.27 | 3.68 | 3.68 |
| 300.31 | 2.78 | 2.78 |
| 269.34 | 3.43 | 3.43 |
| 234.69 | 1.78 | 1.78 |
| 502.47 | 6.00 | 6.00 |
| 512.79 | 4.20 | 4.20 |
| 486.55 | 2.61 | 2.61 |
| 440.89 | 3.93 | 3.93 |
| 291.31 | 3.28 | 3.28 |
| 433.49 | 3.63 | 3.63 |
| 350.42 | 4.43 | 4.43 |
| 343.77 | 3.58 | 3.58 |
| 488.05 | 4.35 | 4.35 |
| 530.37 | 3.45 | 3.45 |
| 265.27 | 2.36 | 2.36 |
| 458.28 | 5.05 | 5.05 |
| 403.43 | 1.46 | 1.46 |
| 450.41 | 3.85 | 3.85 |
| 355.44 | 2.73 | 2.73 |
| 410.45 | 1.48 | 1.48 |
| 334.83 | 6.05 | 6.05 |
| 270.29 | 1.46 | 1.46 |
| 260.30 | 3.16 | 3.16 |
| 499.39 | 3.06 | 3.06 |
| 327.34 | 1.64 | 1.64 |
| 323.40 | 2.72 | 2.72 |
| 506.63 | 5.30 | 5.30 |
| 471.65 | 3.99 | 3.99 |
| 406.44 | 3.28 | 3.28 |
| 449.53 | 3.98 | 3.98 |
| 212.25 | 2.40 | 2.40 |
| 316.31 | 0.62 | 0.62 |
| 338.46 | 4.02 | 4.02 |
| 387.36 | 1.68 | 1.68 |
| 411.89 | 4.58 | 4.58 |
| 415.02 | 6.09 | 6.09 |
| 362.41 | 0.53 | 0.53 |
| 293.37 | 3.96 | 3.96 |
| 440.34 | 4.71 | 4.71 |
| 295.29 | 1.11 | 1.11 |
| 406.80 | 4.20 | 4.20 |
| 410.47 | 4.10 | 4.10 |
| 293.26 | 0.67 | 0.67 |
| 360.37 | 2.01 | 2.01 |
| 387.45 | 5.79 | 5.79 |
| 468.54 | 3.60 | 3.60 |
| 427.47 | 5.55 | 5.55 |
| 417.46 | 1.59 | 1.59 |
| 485.07 | 5.36 | 5.36 |
| 408.09 | 5.08 | 5.08 |
| 530.37 | 3.48 | 3.48 |
| 259.53 | 2.58 | 2.58 |
| 243.26 | 1.13 | 1.13 |
| 350.16 | 2.49 | 2.49 |
| 374.49 | 3.72 | 3.72 |
| 522.61 | 3.98 | 3.98 |
| 466.55 | 4.55 | 4.55 |
| 392.51 | 6.33 | 6.33 |
| 270.25 | -0.56 | -0.56 |
| 406.44 | 4.41 | 4.41 |
| 346.39 | 3.40 | 3.40 |
| 504.41 | 2.66 | 2.66 |
| 419.48 | 3.53 | 3.53 |
| 251.29 | 2.41 | 2.41 |
| 483.98 | 4.63 | 4.63 |
| 289.33 | 1.08 | 1.08 |
| 464.48 | 3.20 | 3.20 |
| 436.60 | 4.51 | 4.51 |
| 227.27 | 1.30 | 1.30 |
| 380.29 | 3.65 | 3.65 |
| 379.34 | 2.99 | 2.99 |
| 518.39 | 2.22 | 2.22 |
| 366.47 | 2.74 | 2.74 |
| 408.55 | 3.53 | 3.53 |
| 409.41 | 4.30 | 4.30 |
| 548.39 | 2.94 | 2.94 |
| 366.51 | 2.49 | 2.49 |
| 469.95 | 4.24 | 4.24 |
| 487.08 | 6.04 | 6.04 |
| 378.38 | 2.42 | 2.42 |
| 425.51 | 1.89 | 1.89 |
| 302.80 | 2.64 | 2.64 |
| 545.27 | 4.26 | 4.26 |
| 261.29 | 2.65 | 2.65 |
| 492.58 | 3.07 | 3.07 |
| 376.50 | 4.62 | 4.62 |
| 278.27 | 0.68 | 0.68 |
| 352.35 | 2.39 | 2.39 |
| 487.08 | 6.04 | 6.04 |
| 227.31 | 3.57 | 3.57 |
| 436.35 | 3.47 | 3.47 |
| 323.74 | 2.25 | 2.25 |
| 284.31 | 4.40 | 4.40 |
| 275.26 | 3.12 | 3.12 |
| 427.47 | 6.26 | 6.26 |
| 194.30 | 2.57 | 2.57 |
| 449.53 | 3.83 | 3.83 |
| 284.75 | 3.32 | 3.32 |
| 281.27 | 1.18 | 1.18 |
| 272.26 | 0.80 | 0.80 |
| 214.18 | 0.89 | 0.89 |
| 355.44 | 2.73 | 2.73 |
| 281.31 | 2.42 | 2.42 |
| 372.38 | 3.69 | 3.69 |
| 353.38 | 1.96 | 1.96 |
| 496.95 | 2.88 | 2.88 |
| 507.50 | 6.38 | 6.38 |
| 316.40 | 4.03 | 4.03 |
| 486.53 | 4.26 | 4.26 |
| 485.64 | 5.83 | 5.83 |
| 373.46 | 4.99 | 4.99 |
| 326.44 | 4.26 | 4.26 |
| 420.47 | 5.35 | 5.35 |
| 528.43 | 4.74 | 4.74 |
| 514.40 | 4.35 | 4.35 |
| 376.21 | 3.32 | 3.32 |
| 254.26 | 3.82 | 3.82 |
| 307.42 | 4.83 | 4.83 |
| 372.28 | 2.86 | 2.86 |
| 261.28 | 1.68 | 1.68 |
| 331.80 | 3.70 | 3.70 |
| 251.24 | 3.05 | 3.05 |
| 503.08 | 5.74 | 5.74 |
| 385.42 | 2.00 | 2.00 |
| 256.22 | ||
| 387.83 | 4.55 | 4.55 |
| 202.21 | 2.02 | 2.02 |
| 481.64 | 4.84 | 4.84 |
| 390.44 | 5.34 | 5.34 |
| 343.80 | 3.48 | 3.48 |
| 489.56 | 3.97 | 3.97 |
| 359.35 | 2.30 | 2.30 |
| 278.38 | 3.34 | 3.34 |
| 504.33 | 4.35 | 4.35 |
| 376.41 | 2.92 | 2.92 |
| 318.80 | 2.59 | 2.59 |
| 466.93 | 3.12 | 3.12 |
| 325.32 | 1.84 | 1.84 |
| 330.34 | 4.17 | 4.17 |
| 414.51 | 4.67 | 4.67 |
| 312.35 | 3.57 | 3.57 |
| 399.45 | 4.33 | 4.33 |
| 551.08 | 9.23 | 9.23 |
| 528.43 | 4.59 | 4.59 |
| 449.39 | 6.42 | 6.42 |
| 321.33 | 3.08 | 3.08 |
| 465.41 | 4.74 | 4.74 |
| 300.34 | 1.76 | 1.76 |
| 279.34 | 3.72 | 3.72 |
| 505.60 | 6.65 | 6.65 |
| 463.54 | 5.50 | 5.50 |
| 260.25 | 0.65 | 0.65 |
| 312.38 | 2.05 | 2.05 |
| 277.32 | 3.47 | 3.47 |
| 378.38 | 2.42 | 2.42 |
| 384.82 | 4.25 | 4.25 |
| 468.54 | 1.46 | 1.46 |
| 382.42 | 4.13 | 4.13 |
| 429.44 | 0.81 | 0.81 |
| 403.87 | 5.16 | 5.16 |
| 405.46 | 3.37 | 3.37 |
| 264.33 | 4.10 | 4.10 |
| 290.27 | 0.63 | 0.63 |
| 329.20 | 4.32 | 4.32 |
| 513.54 | 3.13 | 3.13 |
| 486.48 | 3.48 | 3.48 |
| 515.48 | 4.48 | 4.48 |
| 589.16 | 4.78 | 4.78 |
| 150.18 | 0.33 | 0.33 |
| 214.18 | 1.79 | 1.79 |
| 323.40 | 1.87 | 1.87 |
| 518.43 | 4.41 | 4.41 |
| 571.24 | 5.01 | 5.01 |
| 452.52 | 2.75 | 2.75 |
| 260.25 | 0.59 | 0.59 |
| 537.05 | 8.84 | 8.84 |
| 367.49 | 5.03 | 5.03 |
| 418.47 | 3.99 | 3.99 |
| 308.34 | 3.86 | 3.86 |
| 243.27 | 2.11 | 2.11 |
| 432.27 | 4.26 | 4.26 |
| 319.74 | 2.31 | 2.31 |
| 489.38 | 5.72 | 5.72 |
| 319.57 | 6.17 | 6.17 |
| 297.36 | 3.58 | 3.58 |
| 369.47 | 2.98 | 2.98 |
| 302.29 | 3.29 | 3.29 |
| 329.74 | 1.77 | 1.77 |
| 187.20 | 1.85 | 1.85 |
| 731.77 | 7.43 | 7.43 |
| 237.26 | 3.08 | 3.08 |
| 354.41 | 5.55 | 5.55 |
| 179.14 | -1.59 | -1.59 |
| 296.33 | 3.70 | 3.70 |
| 230.27 | 1.78 | 1.78 |
| 345.20 | 4.46 | 4.46 |
| 270.72 | 4.34 | 4.34 |
| 494.61 | 3.80 | 3.80 |
| 532.49 | 4.77 | 4.77 |
| 352.44 | 2.83 | 2.83 |
| 368.44 | 2.53 | 2.53 |
| 284.37 | 2.05 | 2.05 |
| 352.44 | 2.83 | 2.83 |
| 400.44 | 1.01 | 1.01 |
| 406.08 | 5.22 | 5.22 |
| 288.35 | 4.04 | 4.04 |
| 257.77 | 3.10 | 3.10 |
| 460.51 | 4.37 | 4.37 |
| 429.52 | 3.69 | 3.69 |
| 1218.65 | ||
| 574.49 | 1.11 | 1.11 |
| 392.84 | 3.56 | 3.56 |
| 446.48 | 4.06 | 4.06 |
| 432.50 | 4.32 | 4.32 |
| 348.40 | 4.07 | 4.07 |
| 388.40 | 3.42 | 3.42 |
| 392.42 | 3.97 | 3.97 |
| 1275.74 | ||
| 424.50 | 4.77 | 4.77 |
| 1162.54 | ||
| 265.27 | 3.15 | 3.15 |
| 451.53 | 4.08 | 4.08 |
| 432.46 | 3.76 | 3.76 |
| 446.48 | 4.06 | 4.06 |
| 310.38 | 3.65 | 3.65 |
| 264.16 | 3.14 | 3.14 |
| 450.45 | 3.89 | 3.89 |
| 1317.78 | ||
| 438.42 | 1.18 | 1.18 |
| 442.95 | 5.08 | 5.08 |
| 531.48 | 5.41 | 5.41 |
| 353.38 | 2.89 | 2.89 |
| 337.38 | 3.19 | 3.19 |
| 402.25 | 3.65 | 3.65 |
| 521.40 | 5.87 | 5.87 |
| 526.59 | 4.47 | 4.47 |
| 330.26 | 1.40 | 1.40 |
| 338.34 | 2.38 | 2.38 |
| 371.40 | 2.77 | 2.77 |
| 378.39 | 1.76 | 1.76 |
| 508.62 | 4.22 | 4.22 |
| 480.57 | 3.49 | 3.49 |
| 478.55 | 5.97 | 5.97 |
| 408.50 | 4.43 | 4.43 |
| 324.34 | 1.68 | 1.68 |
| 322.41 | 1.56 | 1.56 |
| 460.51 | 4.32 | 4.32 |
| 384.40 | 2.15 | 2.15 |
| 434.47 | 3.77 | 3.77 |
| 352.35 | 2.06 | 2.06 |
| 336.31 | 3.01 | 3.01 |
| 422.53 | 4.74 | 4.74 |
| 419.47 | 2.80 | 2.80 |
| 531.48 | 5.41 | 5.41 |
| 314.39 | 2.06 | 2.06 |
| 352.36 | 3.07 | 3.07 |
| 356.33 | 3.20 | 3.20 |
| 293.28 | 2.60 | 2.60 |
| 494.59 | 3.85 | 3.85 |
| 548.60 | 3.18 | 3.18 |
| 314.39 | 2.06 | 2.06 |
| 460.51 | 4.32 | 4.32 |
| 452.51 | 3.91 | 3.91 |
| 366.47 | 3.13 | 3.13 |
| 408.50 | 4.43 | 4.43 |
| 480.57 | 3.54 | 3.54 |
| 352.44 | 2.83 | 2.83 |
| 474.54 | 4.68 | 4.68 |
| 310.38 | 3.65 | 3.65 |
| 230.23 | 1.33 | 1.33 |
| 490.49 | 3.54 | 3.54 |
| 326.38 | 3.35 | 3.35 |
| 365.35 | 2.56 | 2.56 |
| 369.37 | 3.67 | 3.67 |
| 320.82 | 2.84 | 2.84 |
| 324.34 | 2.55 | 2.55 |
| 482.54 | 2.93 | 2.93 |
| 323.35 | 4.04 | 4.04 |
| 322.36 | 2.73 | 2.73 |
| 410.52 | 2.72 | 2.72 |