Basic Information
ID: ALA1794445
Type: Functional
Description: PUBCHEM_BIOASSAY: Fluorescence polarization-based cell-based high throughput dose response assay to identify activators of insulin-degrading enzyme (IDE). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493087, AID493124, AID588681]
Activity Charts
Bioactivity
Activity Types for Assay ALA1794445
EC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 244.32 | 0.80 | 0.80 |
| 337.81 | 4.43 | 4.43 |
| 280.28 | 2.39 | 2.39 |
| 259.74 | 1.98 | 1.98 |
| 417.63 | 6.79 | 6.79 |
| 563.99 | 1.03 | 1.03 |
| 457.91 | 1.85 | 1.85 |
| 347.46 | 6.25 | 6.25 |
| 496.03 | 5.84 | 5.84 |
| 345.20 | 4.76 | 4.76 |
| 561.15 | 5.39 | 5.39 |
| 416.52 | 3.72 | 3.72 |
| 591.72 | 8.05 | 8.05 |
| 687.71 | 10.29 | 10.29 |
| 214.26 | 1.09 | 1.09 |
| 292.34 | 4.09 | 4.09 |
| 375.43 | 2.31 | 2.31 |
| 334.38 | 3.60 | 3.60 |
| 412.96 | 5.17 | 5.17 |
| 446.51 | 2.43 | 2.43 |
| 352.35 | 2.32 | 2.32 |
| 421.47 | 3.52 | 3.52 |
| 290.41 | 1.91 | 1.91 |
| 254.20 | 0.42 | 0.42 |
| 511.52 | 5.99 | 5.99 |
| 471.04 | 5.05 | 5.05 |
| 288.26 | 2.56 | 2.56 |
| 528.57 | 3.55 | 3.55 |
| 240.26 | 1.56 | 1.56 |
| 532.99 | 3.13 | 3.13 |
| 281.40 | 4.08 | 4.08 |
| 417.47 | 3.56 | 3.56 |
| 501.61 | 3.04 | 3.04 |
| 268.32 | 2.66 | 2.66 |
| 243.31 | 2.90 | 2.90 |
| 367.43 | 3.20 | 3.20 |
| 529.39 | 2.78 | 2.78 |
| 221.26 | 1.74 | 1.74 |
| 368.43 | 5.61 | 5.61 |
| 474.68 | 4.20 | 4.20 |
| 324.38 | 4.00 | 4.00 |
| 358.35 | 4.48 | 4.48 |
| 561.53 | 6.87 | 6.87 |
| 267.38 | 3.69 | 3.69 |
| 450.29 | 5.40 | 5.40 |
| 328.33 | 0.76 | 0.76 |
| 488.71 | 4.43 | 4.43 |
| 354.90 | 3.54 | 3.54 |
| 421.43 | 5.24 | 5.24 |
| 262.34 | 1.81 | 1.81 |
| 493.67 | 1.30 | 1.30 |
| 286.28 | 1.61 | 1.61 |
| 323.74 | 4.00 | 4.00 |
| 491.98 | 4.86 | 4.86 |
| 352.39 | 1.54 | 1.54 |
| 347.39 | 4.39 | 4.39 |
| 418.38 | 3.82 | 3.82 |
| 296.33 | 2.29 | 2.29 |
| 240.26 | 2.11 | 2.11 |
| 540.73 | 5.04 | 5.04 |
| 373.50 | 3.52 | 3.52 |
| 367.36 | 3.27 | 3.27 |
| 300.23 | 2.57 | 2.57 |
| 347.33 | 3.55 | 3.55 |
| 456.55 | 4.01 | 4.01 |
| 412.96 | 5.17 | 5.17 |
| 300.25 | 2.24 | 2.24 |
| 335.79 | 2.62 | 2.62 |
| 411.48 | 3.04 | 3.04 |
| 329.44 | 3.84 | 3.84 |
| 226.23 | 1.25 | 1.25 |
| 389.45 | 5.22 | 5.22 |
| 342.40 | 5.03 | 5.03 |
| 265.27 | 3.44 | 3.44 |
| 464.45 | 4.79 | 4.79 |
| 223.28 | 2.58 | 2.58 |
| 278.27 | 3.04 | 3.04 |
| 422.36 | 3.52 | 3.52 |
| 395.28 | 3.36 | 3.36 |
| 303.32 | 3.34 | 3.34 |
| 421.46 | 4.98 | 4.98 |
| 470.60 | 1.61 | 1.61 |
| 242.23 | 3.51 | 3.51 |
| 212.25 | 2.98 | 2.98 |
| 360.43 | 1.46 | 1.46 |
| 307.37 | 2.55 | 2.55 |
| 319.39 | 1.56 | 1.56 |
| 466.47 | 5.94 | 5.94 |
| 293.28 | 4.05 | 4.05 |
| 501.07 | 5.06 | 5.06 |
| 404.51 | 3.50 | 3.50 |
| 475.61 | 5.50 | 5.50 |
| 362.82 | -1.89 | -1.89 |
| 324.42 | 4.45 | 4.45 |
| 254.72 | 2.24 | 2.24 |
| 358.38 | 1.57 | 1.57 |
| 422.46 | 5.51 | 5.51 |
| 441.63 | 5.40 | 5.40 |
| 585.64 | 4.67 | 4.67 |
| 468.45 | 4.93 | 4.93 |
| 482.88 | 4.98 | 4.98 |
| 340.85 | 4.98 | 4.98 |
| 302.80 | 2.64 | 2.64 |
| 229.32 | 3.45 | 3.45 |
| 278.72 | 3.88 | 3.88 |
| 465.77 | 5.94 | 5.94 |
| 264.38 | 3.27 | 3.27 |
| 416.39 | 4.11 | 4.11 |
| 487.08 | 6.04 | 6.04 |
| 430.49 | 0.91 | 0.91 |
| 478.81 | 4.72 | 4.72 |
| 454.42 | 4.62 | 4.62 |
| 308.43 | 2.98 | 2.98 |
| 461.59 | 5.19 | 5.19 |
| 211.23 | 1.83 | 1.83 |
| 458.39 | 4.45 | 4.45 |
| 352.39 | 4.54 | 4.54 |
| 222.25 | 2.91 | 2.91 |
| 297.31 | 2.65 | 2.65 |
| 535.56 | 4.73 | 4.73 |
| 465.69 | 5.31 | 5.31 |
| 485.64 | 5.83 | 5.83 |
| 293.41 | 4.22 | 4.22 |
| 294.69 | 2.16 | 2.16 |
| 373.41 | 2.93 | 2.93 |
| 477.97 | 5.63 | 5.63 |
| 251.24 | 3.05 | 3.05 |
| 449.50 | 1.94 | 1.94 |
| 262.31 | 4.08 | 4.08 |
| 318.33 | -0.13 | -0.13 |
| 405.76 | 3.91 | 3.91 |
| 403.56 | 4.76 | 4.76 |
| 314.44 | 2.04 | 2.04 |
| 393.53 | 4.99 | 4.99 |
| 372.81 | 3.92 | 3.92 |
| 269.37 | 2.39 | 2.39 |
| 480.06 | 4.49 | 4.49 |
| 293.28 | 2.93 | 2.93 |
| 301.81 | 2.74 | 2.74 |
| 351.52 | 3.15 | 3.15 |
| 398.85 | 4.05 | 4.05 |
| 467.47 | 3.02 | 3.02 |
| 226.21 | 2.11 | 2.11 |
| 488.90 | 5.34 | 5.34 |
| 411.96 | 3.01 | 3.01 |
| 408.44 | 0.99 | 0.99 |
| 253.26 | 3.39 | 3.39 |
| 410.38 | 3.71 | 3.71 |
| 431.51 | 1.98 | 1.98 |
| 457.56 | 3.87 | 3.87 |
| 258.23 | 3.04 | 3.04 |
| 288.22 | -0.04 | -0.04 |
| 325.41 | 4.25 | 4.25 |
| 376.28 | 3.85 | 3.85 |
| 366.47 | 2.99 | 2.99 |
| 379.40 | 4.76 | 4.76 |
| 249.23 | 1.29 | 1.29 |
| 412.24 | 4.45 | 4.45 |
| 322.36 | 4.10 | 4.10 |
| 452.39 | 5.94 | 5.94 |
| 297.31 | 2.85 | 2.85 |
| 497.50 | 3.03 | 3.03 |
| 395.17 | 4.84 | 4.84 |
| 321.36 | 1.91 | 1.91 |
| 488.71 | 4.73 | 4.73 |
| 281.36 | 2.68 | 2.68 |
| 496.08 | 5.42 | 5.42 |
| 288.30 | 4.27 | 4.27 |
| 321.37 | 1.56 | 1.56 |
| 585.32 | 4.93 | 4.93 |
| 452.58 | 3.63 | 3.63 |
| 346.41 | 2.84 | 2.84 |
| 441.44 | 2.30 | 2.30 |
| 386.48 | 3.22 | 3.22 |
| 450.56 | 2.40 | 2.40 |
| 351.38 | 0.37 | 0.37 |
| 434.47 | 0.66 | 0.66 |
| 487.97 | 2.92 | 2.92 |
| 323.13 | 2.28 | 2.28 |
| 385.49 | 3.45 | 3.45 |
| 491.61 | 1.86 | 1.86 |
| 296.20 | 1.98 | 1.98 |
| 336.33 | 1.83 | 1.83 |
| 320.35 | 2.46 | 2.46 |
| 282.34 | 3.06 | 3.06 |
| 441.47 | 3.44 | 3.44 |
| 478.62 | 3.62 | 3.62 |
| 248.29 | 2.99 | 2.99 |
| 298.37 | 3.25 | 3.25 |
| 461.50 | 1.18 | 1.18 |
| 443.55 | 3.67 | 3.67 |
| 515.40 | 5.18 | 5.18 |
| 388.92 | 7.24 | 7.24 |
| 388.25 | 5.01 | 5.01 |
| 293.32 | 0.97 | 0.97 |
| 382.47 | 1.59 | 1.59 |
| 418.45 | 1.93 | 1.93 |
| 249.32 | 0.85 | 0.85 |
| 1301.83 | ||
| 1246.66 | ||
| 1218.65 | ||
| 321.34 | 2.71 | 2.71 |
| 366.43 | 3.14 | 3.14 |
| 1222.66 | ||
| 1162.54 | ||
| 1306.78 | ||
| 1329.84 | ||
| 1306.78 | ||
| 332.40 | 4.26 | 4.26 |
| 468.55 | 5.50 | 5.50 |
| 1222.66 | ||
| 1275.74 | ||
| 1162.54 | ||
| 526.63 | 6.29 | 6.29 |
| 377.43 | 3.50 | 3.50 |
| 425.45 | 3.47 | 3.47 |
| 370.21 | 3.47 | 3.47 |
| 305.34 | 3.74 | 3.74 |
| 339.40 | 2.28 | 2.28 |
| 390.85 | 2.09 | 2.09 |
| 354.23 | 3.27 | 3.27 |
| 801.02 | 1.36 | 1.36 |