Basic Information
ID: ALA1803626
Type: Binding
Description: Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor substrate after 1 hr by fluorometric assay
Format: BAO_0000357
Organism: Homo sapiens
Target: Isoprenylcysteine carboxyl methyltransferase(ALA4699)
Document: ALA1800067
Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor substrate after 1 hr by fluorometric assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA1803626
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 417.55 | 5.84 | 5.84 |
| 417.55 | 5.89 | 5.89 |
| 542.71 | 5.27 | 5.27 |
| 323.44 | 4.54 | 4.54 |
| 353.46 | 4.55 | 4.55 |
| 357.88 | 5.20 | 5.20 |
| 354.45 | 4.30 | 4.30 |
| 358.87 | 4.95 | 4.95 |
| 340.49 | 4.46 | 4.46 |
| 370.52 | 4.47 | 4.47 |
| 374.94 | 5.11 | 5.11 |
| 358.48 | 4.60 | 4.60 |
| 323.48 | 5.04 | 5.04 |
| 337.51 | 5.35 | 5.35 |
| 351.49 | 4.96 | 4.96 |
| 309.45 | 5.02 | 5.02 |
| 323.48 | 5.32 | 5.32 |
| 323.48 | 5.32 | 5.32 |
| 323.48 | 5.32 | 5.32 |
| 337.51 | 5.63 | 5.63 |
| 337.51 | 5.63 | 5.63 |
| 337.51 | 5.58 | 5.58 |
| 351.53 | 6.14 | 6.14 |
| 351.53 | 6.14 | 6.14 |
| 365.56 | 6.31 | 6.31 |
| 365.56 | 6.31 | 6.31 |
| 339.48 | 5.02 | 5.02 |
| 339.48 | 5.02 | 5.02 |
| 353.51 | 5.33 | 5.33 |
| 369.51 | 5.03 | 5.03 |
| 393.45 | 5.91 | 5.91 |
| 393.45 | 5.91 | 5.91 |
| 352.52 | 5.08 | 5.08 |
| 325.45 | 4.72 | 4.72 |
| 334.46 | 4.89 | 4.89 |
| 334.46 | 4.89 | 4.89 |
| 343.90 | 5.67 | 5.67 |
| 343.90 | 5.67 | 5.67 |
| 378.34 | 6.32 | 6.32 |
| 378.34 | 6.32 | 6.32 |
| 357.93 | 5.98 | 5.98 |
| 357.93 | 5.98 | 5.98 |
| 327.44 | 5.15 | 5.15 |
| 327.44 | 5.15 | 5.15 |
| 327.44 | 5.15 | 5.15 |
| 341.47 | 5.46 | 5.46 |
| 357.47 | 5.16 | 5.16 |
| 375.46 | 5.30 | 5.30 |
| 361.89 | 5.81 | 5.81 |
| 361.89 | 5.81 | 5.81 |
| 361.89 | 5.81 | 5.81 |
| 377.45 | 6.03 | 6.03 |
| 354.45 | 4.92 | 4.92 |
| 354.45 | 4.92 | 4.92 |
| 388.53 | 3.66 | 3.66 |
| 416.59 | 4.27 | 4.27 |
| 366.51 | 4.97 | 4.97 |
| 381.52 | 5.19 | 5.19 |
| 353.46 | 4.71 | 4.71 |
| 353.51 | 5.33 | 5.33 |
| 369.51 | 5.03 | 5.03 |
| 373.92 | 5.68 | 5.68 |
| 373.92 | 5.68 | 5.68 |
| 357.47 | 5.16 | 5.16 |
| 357.47 | 5.16 | 5.16 |
| 345.51 | 5.09 | 5.09 |
| 315.48 | 5.08 | 5.08 |
| 349.93 | 5.73 | 5.73 |
| 295.43 | 4.55 | 4.55 |
| 311.43 | 4.25 | 4.25 |
| 315.84 | 4.89 | 4.89 |
| 299.39 | 4.38 | 4.38 |
| 329.87 | 5.20 | 5.20 |
| 337.51 | 5.79 | 5.79 |
| 367.53 | 5.80 | 5.80 |
| 482.50 | 8.83 | 8.83 |
| 353.58 | 6.51 | 6.51 |
| 383.60 | 6.52 | 6.52 |
| 388.02 | 7.16 | 7.16 |
| 366.55 | 5.38 | 5.38 |
| 370.97 | 6.02 | 6.02 |
| 354.51 | 5.51 | 5.51 |
| 385.00 | 6.33 | 6.33 |
| 339.48 | 5.02 | 5.02 |
| 339.48 | 5.02 | 5.02 |