Basic Information
ID: ALA1837428
Type: Binding
Description: Inhibition of human topoisomerase 1 assessed as inhibition of radiolabeled DNA fragment cleavage 0.1 to 100 uM after 20 mins by gel-based phosphoimaging relative to control
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA1837428
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 365.34 | 2.50 | 2.50 |
| 332.40 | 3.16 | 3.16 |
| 392.46 | 3.18 | 3.18 |
| 377.40 | 3.07 | 3.07 |
| 333.39 | 2.56 | 2.56 |
| 393.44 | 2.58 | 2.58 |
| 378.39 | 2.47 | 2.47 |
| 375.43 | 2.33 | 2.33 |
| 435.48 | 2.35 | 2.35 |
| 420.43 | 2.24 | 2.24 |
| 356.39 | 2.89 | 2.89 |
| 416.44 | 2.91 | 2.91 |
| 349.39 | 1.58 | 1.58 |
| 409.44 | 1.60 | 1.60 |
| 365.39 | 1.97 | 1.97 |