Basic Information
ID: ALA1909134
Type: Binding
Description: DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)
Format: BAO_0000219
Cell type: BTI-TN-5B1-4
Target: Cytochrome P450 2C19(ALA3622)
Document: ALA1909046
DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin): 15
Activity Charts
Bioactivity
Activity Types for Assay ALA1909134
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 182.65 | -0.21 | -0.21 |
| 266.34 | 0.45 | 0.45 |
| 180.16 | 1.31 | 1.31 |
| 385.51 | 2.09 | 2.09 |
| 348.36 | 2.08 | 2.08 |
| 654.61 | 3.19 | 3.19 |
| 371.82 | 3.10 | 3.10 |
| 749.00 | 1.90 | 1.90 |
| 122.12 | 1.38 | 1.38 |
| 158.20 | 1.93 | 1.93 |
| 236.27 | 3.39 | 3.39 |
| 194.19 | -1.03 | -1.03 |
| 157.01 | 2.45 | 2.45 |
| 165.19 | 1.45 | 1.45 |
| 188.23 | 1.48 | 1.48 |
| 392.47 | 1.90 | 1.90 |
| 272.39 | 3.61 | 3.61 |
| 136.20 | 0.84 | 0.84 |
| 213.66 | 1.86 | 1.86 |
| 252.27 | 2.86 | 2.86 |
| 108.14 | 1.18 | 1.18 |
| 272.30 | 4.61 | 4.61 |
| 376.50 | 5.12 | 5.12 |
| 252.32 | 5.74 | 5.74 |
| 321.97 | 6.20 | 6.20 |
| 356.06 | 5.86 | 5.86 |
| 219.24 | 1.46 | 1.46 |
| 246.31 | -0.28 | -0.28 |
| 361.83 | 3.55 | 3.55 |
| 435.44 | -1.17 | -1.17 |
| 424.50 | 2.57 | 2.57 |
| 292.14 | 1.76 | 1.76 |
| 458.58 | 5.35 | 5.35 |
| 153.82 | 2.55 | 2.55 |
| 195.22 | 2.68 | 2.68 |
| 196.20 | 0.64 | 0.64 |
| 239.75 | 3.30 | 3.30 |
| 361.40 | 4.11 | 4.11 |
| 305.42 | 3.79 | 3.79 |
| 430.38 | 2.88 | 2.88 |
| 317.48 | 5.77 | 5.77 |
| 440.46 | 4.03 | 4.03 |
| 290.45 | 3.96 | 3.96 |
| 334.17 | 2.89 | 2.89 |
| 313.79 | 3.43 | 3.43 |
| 228.29 | 3.42 | 3.42 |
| 284.31 | 2.90 | 2.90 |
| 193.25 | 2.23 | 2.23 |
| 301.73 | 4.34 | 4.34 |
| 265.31 | 0.50 | 0.50 |
| 380.49 | 4.47 | 4.47 |
| 678.49 | ||
| 430.54 | 2.72 | 2.72 |
| 307.39 | 2.77 | 2.77 |
| 293.37 | 2.93 | 2.93 |
| 548.63 | 3.48 | 3.48 |
| 448.09 | 6.07 | 6.07 |
| 440.42 | 0.24 | 0.24 |
| 424.09 | 5.46 | 5.46 |
| 210.28 | 0.07 | 0.07 |
| 1134.99 | ||
| 136.11 | 0.06 | 0.06 |
| 558.65 | 6.31 | 6.31 |
| 244.21 | -3.17 | -3.17 |
| 376.14 | 4.56 | 4.56 |
| 245.19 | -3.46 | -3.46 |
| 461.50 | 0.09 | 0.09 |
| 277.27 | 1.15 | 1.15 |
| 390.56 | 6.43 | 6.43 |
| 249.34 | 2.80 | 2.80 |
| 176.12 | -1.41 | -1.41 |
| 217.29 | 0.63 | 0.63 |
| 289.38 | 1.93 | 1.93 |
| 371.30 | -1.74 | -1.74 |
| 367.45 | 2.23 | 2.23 |
| 408.92 | 2.17 | 2.17 |
| 811.88 | 3.16 | 3.16 |
| 332.50 | 5.71 | 5.71 |
| 803.00 | 1.67 | 1.67 |
| 186.24 | 1.56 | 1.56 |
| 298.38 | 2.84 | 2.84 |
| 282.34 | 2.39 | 2.39 |
| 173.13 | -1.76 | -1.76 |
| 324.90 | 3.90 | 3.90 |
| 1422.72 | ||
| 307.44 | 4.42 | 4.42 |
| 472.45 | 2.01 | 2.01 |
| 357.32 | 2.71 | 2.71 |
| 193.20 | 0.89 | 0.89 |
| 183.18 | 0.78 | 0.78 |
| 286.40 | 3.70 | 3.70 |
| 270.31 | -1.27 | -1.27 |
| 420.43 | -1.04 | -1.04 |
| 252.32 | 5.74 | 5.74 |
| 183.32 | ||
| 230.50 | ||
| 223.07 | 0.60 | 0.60 |
| 349.82 | 1.52 | 1.52 |
| 405.50 | -3.59 | -3.59 |
| 1495.48 |