Basic Information
ID: ALA1935923
Type: Functional
Description: Antagonist activity at TrkB in E18 Sprague-Dawley rat hippocampal neurons assessed as inhibition of BDNF-induced TrkB phosphorylation at Tyr490 at 100 uM preincubated for 1 hr followed by BDNF induction for 10 mins by Western blotting analysis
Organism: Rattus norvegicus
Strain: Sprague-Dawley
Tissue: Hippocampus
Activity Charts
Bioactivity
Activity Types for Assay ALA1935923
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 496.61 | -1.98 | -1.98 |
| 510.64 | -1.59 | -1.59 |
| 454.53 | -3.05 | -3.05 |
| 468.56 | -2.66 | -2.66 |
| 468.56 | -2.66 | -2.66 |
| 482.58 | -2.27 | -2.27 |
| 482.58 | -2.27 | -2.27 |
| 739.88 | -3.91 | -3.91 |
| 1479.75 | ||
| 937.11 | -5.32 | -5.32 |